Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate.
CK2
SAXS
inhibition
polyoxometalate
substrate competitive
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
03
2022
accepted:
18
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
CK2 is a Ser/Thr protein kinase involved in many cellular processes such as gene expression, cell cycle progression, cell growth and differentiation, embryogenesis, and apoptosis. Aberrantly high CK2 activity is widely documented in cancer, but the enzyme is also involved in several other pathologies, such as diabetes, inflammation, neurodegeneration, and viral infections, including COVID-19. Over the last years, a large number of small-molecules able to inhibit the CK2 activity have been reported, mostly acting with an ATP-competitive mechanism. Polyoxometalates (POMs), are metal-oxide polyanionic clusters of various structures and dimensions, with unique chemical and physical properties. POMs were identified as nanomolar CK2 inhibitors, but their mechanism of inhibition and CK2 binding site remained elusive. Here, we present the biochemical and biophysical characterizing of the interaction of CK2α with a ruthenium-based polyoxometalate, [Ru
Identifiants
pubmed: 35720133
doi: 10.3389/fmolb.2022.906390
pii: 906390
pmc: PMC9201508
doi:
Types de publication
Journal Article
Langues
eng
Pagination
906390Informations de copyright
Copyright © 2022 Fabbian, Giachin, Bellanda, Borgo, Ruzzene, Spuri, Campofelice, Veneziano, Bonchio, Carraro and Battistutta.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur J Med Chem. 2020 Jun 1;195:112267
pubmed: 32283296
Angew Chem Int Ed Engl. 2010 Mar 1;49(10):1736-58
pubmed: 20131346
Nat Chem. 2019 Feb;11(2):146-153
pubmed: 30510216
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7
pubmed: 15980490
Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4718-23
pubmed: 15774585
Expert Rev Clin Pharmacol. 2020 Jan;13(1):1-6
pubmed: 31810398
Curr Top Med Chem. 2011;11(11):1340-51
pubmed: 21513497
J Exp Clin Cancer Res. 2019 Jul 5;38(1):287
pubmed: 31277672
J Biol Chem. 2000 Sep 22;275(38):29618-22
pubmed: 10882732
Biochim Biophys Acta. 2008 Jan;1784(1):33-47
pubmed: 17931986
Mol Cell Biochem. 2008 Sep;316(1-2):57-62
pubmed: 18626746
Org Biomol Chem. 2021 May 26;19(20):4380-4396
pubmed: 34037044
Langmuir. 2021 Jun 1;37(21):6475-6489
pubmed: 34010005
Curr Med Chem. 2020;27(3):362-379
pubmed: 31453779
Front Chem. 2018 Jul 11;6:278
pubmed: 30050897
Chem Sci. 2016 Nov 1;7(11):6839-6845
pubmed: 28451126
Biochemistry. 2011 Oct 4;50(39):8478-88
pubmed: 21870818
Pharmacol Res. 2021 Mar;165:105463
pubmed: 33513356
Mol Cell Biochem. 2011 Oct;356(1-2):67-73
pubmed: 21739155
J Biol Chem. 2003 Jan 17;278(3):1831-6
pubmed: 12419810
Chem Biol. 2009 Feb 27;16(2):112-20
pubmed: 19246001
Angew Chem Int Ed Engl. 2019 Mar 4;58(10):2980-2999
pubmed: 29893459
Chem Biol. 2008 Jul 21;15(7):683-92
pubmed: 18635005
Acta Crystallogr D Struct Biol. 2017 Sep 1;73(Pt 9):710-728
pubmed: 28876235
Molecules. 2021 Mar 31;26(7):
pubmed: 33807474
J Synchrotron Radiat. 2013 Jul;20(Pt 4):660-4
pubmed: 23765312
Methods Enzymol. 2010;484:495-514
pubmed: 21036247
Biofactors. 2010 May-Jun;36(3):187-95
pubmed: 20533398
J Struct Biol. 2012 Feb;177(2):382-91
pubmed: 22186626
Crit Rev Biochem Mol Biol. 2021 Aug;56(4):321-359
pubmed: 33843388
Hum Genet. 2021 Jul;140(7):1077-1096
pubmed: 33944995
Biochim Biophys Acta. 2010 Mar;1804(3):499-504
pubmed: 19665589
Protein Sci. 2018 Jan;27(1):112-128
pubmed: 28836357
Biomacromolecules. 2008 Mar;9(3):812-7
pubmed: 18266320
EMBO J. 1998 May 1;17(9):2451-62
pubmed: 9564028
J Med Chem. 2020 Nov 12;63(21):12786-12798
pubmed: 33119282
Adv Protein Chem Struct Biol. 2021;124:23-46
pubmed: 33632467
Signal Transduct Target Ther. 2021 May 17;6(1):183
pubmed: 33994545
Chembiochem. 2007 Oct 15;8(15):1804-9
pubmed: 17768728
Curr Opin Biotechnol. 2019 Aug;58:92-99
pubmed: 30529815
PLoS One. 2012;7(11):e49193
pubmed: 23145120
RSC Adv. 2021 Jan 26;11(9):4952-4957
pubmed: 35424453
J Appl Crystallogr. 2021 Feb 01;54(Pt 1):343-355
pubmed: 33833657
ACS Chem Biol. 2016 Jun 17;11(6):1511-7
pubmed: 26999075
Eur J Med Chem. 2019 Nov 1;181:111581
pubmed: 31400711
J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8
pubmed: 12244125
J Mol Biol. 2003 Jul 25;330(5):925-34
pubmed: 12860116
Biochem J. 2017 Jul 6;474(14):2405-2416
pubmed: 28572157
Biochem J. 2014 Jun 1;460(2):141-56
pubmed: 24825444
Chem Sci. 2018 Feb 20;9(11):3041-3049
pubmed: 29732088
Cell Mol Life Sci. 2009 Jun;66(11-12):1868-89
pubmed: 19387547
J Vis Exp. 2017 Jan 5;(119):
pubmed: 28117806
EMBO J. 2001 Oct 1;20(19):5320-31
pubmed: 11574463
Chem Rev. 2015 Jun 10;115(11):4893-962
pubmed: 25965251
FEBS Lett. 1983 Oct 17;162(2):235-8
pubmed: 6195015
Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1680-4
pubmed: 11092945
ACS Chem Biol. 2014 Feb 21;9(2):366-71
pubmed: 24175891
Cell Mol Life Sci. 2009 Jun;66(11-12):1817-29
pubmed: 19387552
PLoS One. 2017 Dec 4;12(12):e0188854
pubmed: 29206231
Nat Commun. 2020 Jan 3;11(1):41
pubmed: 31900396
J Phys Chem B. 2007 Sep 27;111(38):11253-9
pubmed: 17784743
Dalton Trans. 2017 May 30;46(21):6812-6829
pubmed: 28530742
ACS Chem Biol. 2012 Jul 20;7(7):1158-63
pubmed: 22506723
PLoS One. 2013 Sep 18;8(9):e74232
pubmed: 24058532
PLoS One. 2014 Dec 26;9(12):e115609
pubmed: 25541719