The Acute Effects of Different doses of Tramadol on Neuronal Activity of Medial Prefrontal Cortex in Rats.
Electrophysiology
neurons
prefrontal cortex
tramadol
Journal
Advanced biomedical research
ISSN: 2277-9175
Titre abrégé: Adv Biomed Res
Pays: India
ID NLM: 101586897
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
01
2021
revised:
17
04
2021
accepted:
22
06
2021
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Tramadol is an opioid analgesic with monoamine reuptake inhibitory effects. Although tramadol has been widely used to control pain, there is controversy about the risk of abuse. Therefore, in the present study, the acute effects of tramadol on neuronal activity in the medial prefrontal cortex (mPFC), which is one of the important centers of the reward system, were investigated electrophysiologically. Tramadol was injected interperitoneally (12.5 and 25 mk/kg) or subcutaneously (40 mg/kg) and its effect on the firing of mPFC neurons was investigated, using Tramadol could not significantly affect neural activity in mPFC, suggesting no acute and rapid effect on mPFC. The present results showed that neural activity in mPFC was not rapidly affected by acute application of tramadol. Since the role of mPFC in tramadol addiction has been elucidated, it can be concluded that these effects may be due to delayed responses or chronic use of tramadol.
Sections du résumé
Background
UNASSIGNED
Tramadol is an opioid analgesic with monoamine reuptake inhibitory effects. Although tramadol has been widely used to control pain, there is controversy about the risk of abuse. Therefore, in the present study, the acute effects of tramadol on neuronal activity in the medial prefrontal cortex (mPFC), which is one of the important centers of the reward system, were investigated electrophysiologically.
Materials and Methods
UNASSIGNED
Tramadol was injected interperitoneally (12.5 and 25 mk/kg) or subcutaneously (40 mg/kg) and its effect on the firing of mPFC neurons was investigated, using
Results
UNASSIGNED
Tramadol could not significantly affect neural activity in mPFC, suggesting no acute and rapid effect on mPFC.
Conclusions
UNASSIGNED
The present results showed that neural activity in mPFC was not rapidly affected by acute application of tramadol. Since the role of mPFC in tramadol addiction has been elucidated, it can be concluded that these effects may be due to delayed responses or chronic use of tramadol.
Identifiants
pubmed: 35720219
doi: 10.4103/abr.abr_17_21
pii: ABR-11-24
pmc: PMC9201227
doi:
Types de publication
Journal Article
Langues
eng
Pagination
24Informations de copyright
Copyright: © 2022 Advanced Biomedical Research.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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