Transplantation of SDF-1α-loaded liver extracellular matrix repopulated with autologous cells attenuated liver fibrosis in a rat model.
endogenous progenitor cells mobilization
granulocyte colony stimulating factor
in vivo tissue engineering
liver extracellular matrix scaffold
liver fibrosis
stromal derived factor-1alpha
Journal
EXCLI journal
ISSN: 1611-2156
Titre abrégé: EXCLI J
Pays: Germany
ID NLM: 101299402
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
02
2022
accepted:
20
04
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Cell-based therapy and tissue engineering are promising substitutes for liver transplantation to cure end-stage liver disorders. However, the limited sources for healthy and functional cells and poor engraftment rate are main challenges to the cell-based therapy approach. On the other hand, feasibility of production and size of bioengineered tissues are primary bottlenecks in tissue engineering. Here, we induce regeneration in a rat fibrotic liver model by transplanting a natural bioengineered scaffold with a native microenvironment repopulated with autologous stem/progenitor cells. In the main experimental group, a 1 mm
Identifiants
pubmed: 35721572
doi: 10.17179/excli2022-4761
pii: 2022-4761
pmc: PMC9203988
doi:
Types de publication
Journal Article
Langues
eng
Pagination
704-721Informations de copyright
Copyright © 2022 Najar-Asl et al.
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