Systemic Profile of Cytokines in Arteriovenous Fistula Patients and Their Associations with Maturation Failure.
arteriovenous fistula
chronic kidney disease
cytokine
dialysis
inflammation
Journal
Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381
Informations de publication
Date de publication:
28 04 2022
28 04 2022
Historique:
received:
14
09
2021
accepted:
13
01
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
22
6
2022
Statut:
epublish
Résumé
Systemic cytokines are elevated in patients with chronic kidney disease (CKD) and on hemodialysis compared with the general population. However, whether cytokine levels interfere with vascular remodeling, increasing the risk of arteriovenous fistula (AVF) failure, remains unknown. This is a case-control study of 64 patients who underwent surgery for AVF creation (32 with AVF maturation failure and 32 matching controls with successful maturation). A total of 74 cytokines, including chemokines, interferons, interleukins, and growth factors, were measured in preoperative plasma samples using multiplex assays. Sixty-two patients were included in the statistical analyses. Associations with AVF failure were assessed using paired comparisons and conditional logistic regressions accounting for paired strata. Seven cytokines were significantly higher in patients with AVF maturation failure than in matching controls (G-CSF, IL-6, MDC, RANTES, SDF-1α/β, TGFα, and TPO). Of these, G-CSF (odds ratio [OR]=1.71; 95% confidence interval [95% CI], 1.05 to 2.79 per 10 pg/ml), MDC (OR=1.60, 95% CI, 1.08 to 2.38 per 100 pg/ml), RANTES (OR=1.55, 95% CI, 1.10 to 2.17 per 100 pg/ml), SDF-1 This study identified a profile of plasma cytokines associated with adverse maturation outcomes in AVFs. These findings may open the doors for future therapeutics and markers for risk stratification.
Sections du résumé
Background
Systemic cytokines are elevated in patients with chronic kidney disease (CKD) and on hemodialysis compared with the general population. However, whether cytokine levels interfere with vascular remodeling, increasing the risk of arteriovenous fistula (AVF) failure, remains unknown.
Methods
This is a case-control study of 64 patients who underwent surgery for AVF creation (32 with AVF maturation failure and 32 matching controls with successful maturation). A total of 74 cytokines, including chemokines, interferons, interleukins, and growth factors, were measured in preoperative plasma samples using multiplex assays. Sixty-two patients were included in the statistical analyses. Associations with AVF failure were assessed using paired comparisons and conditional logistic regressions accounting for paired strata.
Results
Seven cytokines were significantly higher in patients with AVF maturation failure than in matching controls (G-CSF, IL-6, MDC, RANTES, SDF-1α/β, TGFα, and TPO). Of these, G-CSF (odds ratio [OR]=1.71; 95% confidence interval [95% CI], 1.05 to 2.79 per 10 pg/ml), MDC (OR=1.60, 95% CI, 1.08 to 2.38 per 100 pg/ml), RANTES (OR=1.55, 95% CI, 1.10 to 2.17 per 100 pg/ml), SDF-1
Conclusions
This study identified a profile of plasma cytokines associated with adverse maturation outcomes in AVFs. These findings may open the doors for future therapeutics and markers for risk stratification.
Identifiants
pubmed: 35721613
doi: 10.34067/KID.0006022021
pii: K3602021000602
pmc: PMC9136910
doi:
Substances chimiques
Chemokine CCL5
0
Chemokine CXCL12
0
Cytokines
0
Transforming Growth Factor alpha
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
677-686Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121227
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL151747
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098511
Pays : United States
Organisme : BLRD VA
ID : I01 BX004658
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132888
Pays : United States
Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
Déclaration de conflit d'intérêts
L.H. Salman reports research funding from Albany Medical Center, Roach funds, and Transonics, Inc.; a patent application for the use of 4-methylumbelliferone in diabetic kidney disease; and other interests/relationships with the American Society of Diagnostic and Interventional Nephrology, American Society of Nephrology, Data Safety Monitoring Board—Phraxis, and the Renal Physician Association. R.I. Vazquez-Padron reports being a scientific advisor for Kidney360 and Scientific Reports, and has other interests/relationships with the National Institutes of Health and American Heart Association study sections. All remaining authors have nothing to disclose.
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