Rethinking Our Concepts and Assumptions About Autism.
autism
diagnosis
heterogeneity
precision medicine
subtype
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
03
2022
accepted:
16
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Autism is a clinical consensus diagnosis made based on behavioral symptoms of early developmental difficulties in domains of social-communication (SC) and restricted repetitive behaviors (RRB). Many readily assume that alongside being optimal for separating individuals based on SC and RRB behavioral domains, that the label should also be highly useful for explaining differential biology, outcomes, and treatment (BOT) responses. However, we also now take for granted the fact that the autism population is vastly heterogeneous at multiple scales, from genome to phenome. In the face of such multi-scale heterogeneity, here we argue that the concept of autism along with the assumptions that surround it require some rethinking. While we should retain the diagnosis for all the good it can do in real-world circumstances, we also call for the allowance of multiple other possible definitions that are better tailored to be highly useful for other translational end goals, such as explaining differential BOT responses.
Identifiants
pubmed: 35722549
doi: 10.3389/fpsyt.2022.903489
pmc: PMC9203718
doi:
Types de publication
Journal Article
Langues
eng
Pagination
903489Informations de copyright
Copyright © 2022 Lombardo and Mandelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Autism Res. 2021 Oct;14(10):2224-2227
pubmed: 34077630
PLoS Biol. 2013;11(4):e1001544
pubmed: 23630456
J Autism Dev Disord. 2014 Jul;44(7):1788-92
pubmed: 24390538
Hum Brain Mapp. 2016 Jan;37(1):230-53
pubmed: 26493275
J Child Psychol Psychiatry. 2021 May;62(5):610-630
pubmed: 33432656
Am J Psychiatry. 2012 Oct;169(10):1056-64
pubmed: 23032385
Am J Hum Genet. 2020 May 7;106(5):587-595
pubmed: 32359473
Autism Res. 2021 Oct;14(10):2213-2220
pubmed: 34077611
Res Dev Disabil. 2010 Nov-Dec;31(6):1543-51
pubmed: 20634041
Hist Psychiatry. 2013 Dec;24(4):442-58
pubmed: 24573754
J Autism Dev Disord. 2005 Apr;35(2):241-57
pubmed: 15909410
Curr Opin Neurobiol. 2007 Feb;17(1):103-11
pubmed: 17275283
Cell. 2020 Feb 6;180(3):568-584.e23
pubmed: 31981491
J Autism Dev Disord. 1979 Mar;9(1):11-29
pubmed: 155684
J Autism Dev Disord. 2008 Jan;38(1):190-7
pubmed: 17410416
Lang Cogn Process. 2001 Apr 1;16(2-3):287-308
pubmed: 16703115
Dev Cogn Neurosci. 2017 Jun;25:5-11
pubmed: 28233663
Autism Res. 2013 Dec;6(6):468-78
pubmed: 24124067
J Child Psychol Psychiatry. 2017 Apr;58(4):411-435
pubmed: 28102566
Autism Res. 2017 Jun;10(6):1107-1119
pubmed: 28301102
J Autism Dev Disord. 2021 Dec;51(12):4291-4308
pubmed: 33474661
Mol Psychiatry. 2020 Dec;25(12):3178-3185
pubmed: 32355335
Eur Child Adolesc Psychiatry. 2004 Aug;13(4):201-8
pubmed: 15365889
Dev Psychopathol. 2015 May;27(2):425-42
pubmed: 25997763
Am J Intellect Dev Disabil. 2014 Jan;119(1):84-99
pubmed: 24450323
Autism Res. 2019 Aug;12(8):1211-1224
pubmed: 31119899
J Child Psychol Psychiatry. 2021 Nov;62(11):1297-1307
pubmed: 34382689
Eur Child Adolesc Psychiatry. 1993 Jan;2(1):61-74
pubmed: 21590530
Cereb Cortex. 2015 Oct;25(10):3613-28
pubmed: 25249409
Neurosci Biobehav Rev. 2018 Jun;89:132-150
pubmed: 29391184
Nat Hum Behav. 2022 Mar;6(3):443-454
pubmed: 34980898
Nat Neurosci. 2006 Oct;9(10):1218-20
pubmed: 17001340
Annu Rev Clin Psychol. 2021 May 7;17:365-389
pubmed: 33577349
Trends Neurosci. 2014 Dec;37(12):683-6
pubmed: 25465942
Lancet. 2022 Jan 15;399(10321):271-334
pubmed: 34883054
Biol Psychiatry. 2020 Jul 1;88(1):111-128
pubmed: 32553193
Sci Adv. 2021 Sep 03;7(36):eabh1663
pubmed: 34516910
Autism Res. 2017 Jan;10(1):10-14
pubmed: 28130875
Nat Neurosci. 2018 Dec;21(12):1680-1688
pubmed: 30482947
J Child Psychol Psychiatry. 1968 Oct;9(1):1-25
pubmed: 4892153
Cereb Cortex Commun. 2020 Oct 23;1(1):tgaa077
pubmed: 34296136
J Child Psychol Psychiatry. 2002 Sep;43(6):807-21
pubmed: 12236615
J Autism Dev Disord. 2021 Dec;51(12):4309-4320
pubmed: 33491120
JAMA Psychiatry. 2019 Nov 1;76(11):1124-1132
pubmed: 31433441
Mol Psychiatry. 2019 Oct;24(10):1435-1450
pubmed: 30617272
Psychol Med. 1981 Feb;11(1):115-29
pubmed: 7208735
Brain. 2016 Feb;139(Pt 2):616-30
pubmed: 26912520
J Child Psychol Psychiatry. 2020 Mar;61(3):218-232
pubmed: 31994188
J Hist Behav Sci. 2018 Jan;54(1):25-42
pubmed: 29244198
Neuron. 2015 Apr 22;86(2):567-77
pubmed: 25864635
Dev Med Child Neurol. 1965 Oct;7(5):518-28
pubmed: 5866448
J Autism Dev Disord. 2021 Dec;51(12):4321-4332
pubmed: 32940822
J Autism Dev Disord. 2021 Dec;51(12):4253-4270
pubmed: 33624215