The Selective Agonist for Sphingosine-1-Phosphate Receptors Siponimod Increases the Expression Level of
CNS resident cells
NR4A
NURR1
fingolimod
multiple sclerosis
siponimod
sphingosine-1-phosphate (S1P) receptors
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
07 Mar 2022
07 Mar 2022
Historique:
received:
28
01
2022
revised:
23
02
2022
accepted:
01
03
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Fingolimod (FTY720) and siponimod (BAF312) are selective agonists for sphingosine-1-phosphate (S1P) receptors approved for the treatment of relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), respectively. BAF312 exerts pro-myelination and neuro-protective functions on CNS resident cells, although the underlying molecular mechanism is not yet fully understood.
Identifiants
pubmed: 35723306
pii: cimb44030083
doi: 10.3390/cimb44030083
pmc: PMC8947415
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1247-1256Références
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