Universal antibody targeting the highly conserved fusion peptide provides cross-protection in mice.
Influenza
Uni-1
antibody-dependent cellular cytotoxicity (ADCC)
cross-protection
universal antibody
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
30 11 2022
30 11 2022
Historique:
pubmed:
21
6
2022
medline:
2
11
2022
entrez:
20
6
2022
Statut:
ppublish
Résumé
Influenza is a major public health concern causing millions of hospitalizations every year. The current vaccines need annual updating based on prediction of likely strains in the upcoming season. However, mismatches between vaccines and the actual circulating viruses can occur, reducing vaccine effectiveness significantly because of the remarkably high rate of mutation in the viral glycoprotein, hemagglutinin (HA). Clearly, it would be of great interest to determine the potential role of universally conserved epitopes in inducing protective immunity. Here, an antibody against the 14-aa fusion peptide sequence at the The fusion peptide is the only universally conserved epitope in both IAV and IBVMono-specific universal antibody induces strong ADCC against human and avian IAVMono-specific universal antibody induces strong ADCC against IBV from both genetic lineages of IBVThe antibody has bi-functional effector functions against several influenza viruses.
Autres résumés
Type: plain-language-summary
(eng)
The fusion peptide is the only universally conserved epitope in both IAV and IBVMono-specific universal antibody induces strong ADCC against human and avian IAVMono-specific universal antibody induces strong ADCC against IBV from both genetic lineages of IBVThe antibody has bi-functional effector functions against several influenza viruses.
Identifiants
pubmed: 35724343
doi: 10.1080/21645515.2022.2083428
pmc: PMC9621047
doi:
Substances chimiques
Hemagglutinin Glycoproteins, Influenza Virus
0
Antibodies, Viral
0
Influenza Vaccines
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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