Paediatric neurocysticercosis in high income countries.

Child Developed Countries Epilepsy / epidemiology Humans Neurocysticercosis / complications Neuroimaging Seizures / complications
Cysticides Neurocysticercosis Taenia solium antihelminthics child

Journal

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
ISSN: 1532-2130
Titre abrégé: Eur J Paediatr Neurol
Pays: England
ID NLM: 9715169

Informations de publication

Date de publication:
07 2022
Historique:
received: 27 10 2021
revised: 03 06 2022
accepted: 06 06 2022
pubmed: 21 6 2022
medline: 20 7 2022
entrez: 20 6 2022
Statut: ppublish

Résumé

Neurocysticercosis (NCC) is an unusual cause of seizures in high income settings. It typically presents as an afebrile seizure in a previously well child and can occur years after migration or travel. Children diagnosed with neurocysticercosis from 01 July 2005 to 30 June 2020 were identified from the electronic medical records of a tertiary children's hospital in Australia. Additionally, a 10-year compilation of case reports of paediatric NCC in high income settings was performed by medline search (publication years 2011-2021). Diagnosis and treatment of neurocysticercosis were reviewed with reference to diagnostic criteria of Del Brutto et al., and the 2017 Infectious Diseases Society of America treatment guidelines. Over a fifteen-year period, eight children were diagnosed with NCC at our hospital in Sydney, Australia. Seizures and history of travel to or migration from South Asia were the two most frequently occurring findings. Children diagnosed after 2016 all received antiparasitic therapy. Outcomes were generally favorable, though long-term epilepsy resulted in some cases. Compiled case reports from high income settings revealed migration and travel exposures commensurate with local demographic patterns, and treatment approaches conforming with 2017 Infectious Diseases Society of America guidelines. Clinicians should be aware of NCC as a differential diagnosis in children from endemic areas presenting with unprovoked seizures as misdiagnosis can occur. Expert review of neuroimaging facilitates diagnosis and can avert unnecessary neurosurgery. In Australia, India was a key exposure country for NCC, reflecting its endemic burden of disease and local travel and migration patterns.

Sections du résumé

BACKGROUND
Neurocysticercosis (NCC) is an unusual cause of seizures in high income settings. It typically presents as an afebrile seizure in a previously well child and can occur years after migration or travel.
METHODS
Children diagnosed with neurocysticercosis from 01 July 2005 to 30 June 2020 were identified from the electronic medical records of a tertiary children's hospital in Australia. Additionally, a 10-year compilation of case reports of paediatric NCC in high income settings was performed by medline search (publication years 2011-2021). Diagnosis and treatment of neurocysticercosis were reviewed with reference to diagnostic criteria of Del Brutto et al., and the 2017 Infectious Diseases Society of America treatment guidelines.
RESULTS
Over a fifteen-year period, eight children were diagnosed with NCC at our hospital in Sydney, Australia. Seizures and history of travel to or migration from South Asia were the two most frequently occurring findings. Children diagnosed after 2016 all received antiparasitic therapy. Outcomes were generally favorable, though long-term epilepsy resulted in some cases. Compiled case reports from high income settings revealed migration and travel exposures commensurate with local demographic patterns, and treatment approaches conforming with 2017 Infectious Diseases Society of America guidelines.
CONCLUSIONS
Clinicians should be aware of NCC as a differential diagnosis in children from endemic areas presenting with unprovoked seizures as misdiagnosis can occur. Expert review of neuroimaging facilitates diagnosis and can avert unnecessary neurosurgery. In Australia, India was a key exposure country for NCC, reflecting its endemic burden of disease and local travel and migration patterns.

Identifiants

DOI: 10.1016/j.ejpn.2022.06.002 PMID: 35724517
pubmed: 35724517
pii: S1090-3798(22)00089-7
doi: 10.1016/j.ejpn.2022.06.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

88-95

Informations de copyright

© 2022 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.

Auteurs

Indhumathi Babu (I)

Department of General Medicine, The Children's Hospital at Westmead, New South Wales, Australia. Electronic address: indhumathi.babu@health.nsw.gov.au.

Annaleise R Howard-Jones (AR)

Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, New South Wales, Australia.

Robert Goetti (R)

Sydney Medical School, University of Sydney, New South Wales, Australia; Department of Medical Imaging, The Children's Hospital at Westmead, New South Wales, Australia.

Manoj P Menezes (MP)

Sydney Medical School, University of Sydney, New South Wales, Australia; Department of Neurology and Neurosurgery, The Children's Hospital at Westmead, New South Wales, Australia.

Susan Arbuckle (S)

Department of Histopathology, The Children's Hospital at Westmead, New South Wales, Australia.

Philip N Britton (PN)

Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, New South Wales, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › Sciences sociales › Internationalité › Coopération internationale › Pays développés › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Infections du système nerveux central › Infections parasitaires du système nerveux central › Helminthiases du système nerveux central › Neurocysticercose › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Paediatric neurocysticercosis in high income countries.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Paediatric neurocysticercosis in high income countries.