Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Journal
The lancet. Diabetes & endocrinology
ISSN: 2213-8595
Titre abrégé: Lancet Diabetes Endocrinol
Pays: England
ID NLM: 101618821
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
16
02
2022
revised:
16
04
2022
accepted:
06
05
2022
pubmed:
21
6
2022
medline:
27
7
2022
entrez:
20
6
2022
Statut:
ppublish
Résumé
Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk. Genetic risk scores (GRS), which facilitate the integration of complex genetic information, have been developed in type 1 diabetes and incorporated into models and algorithms for classification, prognosis, and prediction of disease and response to preventive and therapeutic interventions. However, the development and validation of GRS across different ancestries is still emerging, as is knowledge on type 1 diabetes genetics in populations of diverse genetic ancestries. In this Review, we provide a summary of the current evidence on the evolutionary genetic variation in type 1 diabetes and the racial and ethnic differences in type 1 diabetes epidemiology, clinical characteristics, and preclinical course. We also discuss the influence of genetics on type 1 diabetes with differences across ancestries and the development and validation of GRS in various populations.
Identifiants
pubmed: 35724677
pii: S2213-8587(22)00159-0
doi: 10.1016/S2213-8587(22)00159-0
pmc: PMC10024251
mid: NIHMS1880339
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-608Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG011345
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151152
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG011723
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122586
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010297
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121843
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK111906
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124395
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests RAO received a grant from UK Medical Research Council to partner with Randox for type 1 diabetes GRS biochip development. This work was supported by National Institute of Health grants (grant number R01 DK124395, MJR, RAO, DD, and WAH; R01 DK121843, MJR, RAO, SOG, and SSR; R01 HG010297, CRG and SSR; R01 HG011345, CRG; R01 HL151152, CRG and SSR; DP3 DK111906, SSR; R01 DK122586, SSR; and U01 HG011723, SSR). Funding sources had no role in the writing of this review or the decision to submit the paper for publication. All other authors declare no competing interests. The Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations.
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