MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients.
Esophageal Neoplasms
MicroRNA
Plasma
Squamous Cell Carcinoma
Journal
Journal of Korean medical science
ISSN: 1598-6357
Titre abrégé: J Korean Med Sci
Pays: Korea (South)
ID NLM: 8703518
Informations de publication
Date de publication:
20 Jun 2022
20 Jun 2022
Historique:
received:
08
01
2022
accepted:
16
05
2022
entrez:
21
6
2022
pubmed:
22
6
2022
medline:
23
6
2022
Statut:
epublish
Résumé
Patients with esophageal squamous cell carcinoma (ESCC) have a poor prognosis and there are no effective clinical biomarkers. Recently, stable microRNAs detected in the blood have been suggested as potential biomarkers in various cancers. Therefore, we investigated whether plasma microRNAs could be feasible biomarkers for ESCC. Peripheral blood samples were obtained from 16 healthy volunteers and 66 ESCC patients before treatment between May 2016 and April 2021. Plasma miR-18b, miR-21, miR-31, and miR-375 expression levels were measured using reverse transcription-quantitative polymerase chain reaction. Compared with those in healthy controls, the expression levels of plasma miR-21 were significantly higher ( Our study demonstrated that plasma miR-21, miR-31, and miR-375 could be potential biomarkers for the diagnosis of ESCC. Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with esophageal squamous cell carcinoma (ESCC) have a poor prognosis and there are no effective clinical biomarkers. Recently, stable microRNAs detected in the blood have been suggested as potential biomarkers in various cancers. Therefore, we investigated whether plasma microRNAs could be feasible biomarkers for ESCC.
METHODS
METHODS
Peripheral blood samples were obtained from 16 healthy volunteers and 66 ESCC patients before treatment between May 2016 and April 2021. Plasma miR-18b, miR-21, miR-31, and miR-375 expression levels were measured using reverse transcription-quantitative polymerase chain reaction.
RESULTS
RESULTS
Compared with those in healthy controls, the expression levels of plasma miR-21 were significantly higher (
CONCLUSION
CONCLUSIONS
Our study demonstrated that plasma miR-21, miR-31, and miR-375 could be potential biomarkers for the diagnosis of ESCC. Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls.
Identifiants
pubmed: 35726148
pii: 37.e197
doi: 10.3346/jkms.2022.37.e197
pmc: PMC9247724
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e197Subventions
Organisme : Korean College of Helicobacter and Upper Gastrointestinal Research
ID : KCHUGR-202002503
Pays : Korea
Informations de copyright
© 2022 The Korean Academy of Medical Sciences.
Déclaration de conflit d'intérêts
Conceptualization: Kim GH, I H. Data curation: Kahng DH, Kim GH, Kim S, Lee MW, I H. Formal analysis: Kim GH, Park SJ, Lee MW. Investigation: Kim S, Lee MW, Lee BE. Methodology: Park SJ, Kim S. Project administration: Kim GH. Software: Kahng DH, Park SJ. Supervision: Kim GH. Validation: Lee BE, I H. Visualization: Lee MW. Writing - original draft: Kahng DH, Kim GH. Writing - review & editing: Kahng DH, Kim GH, Park SJ, Kim S, Lee MW, Lee BE, I H.
Références
Trends Cell Biol. 2009 Feb;19(2):43-51
pubmed: 19144520
Gut Liver. 2021 Jul 15;15(4):492-499
pubmed: 32307976
Asian Pac J Cancer Prev. 2012;13(4):1563-7
pubmed: 22799367
Cell Res. 2008 Oct;18(10):997-1006
pubmed: 18766170
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
pubmed: 18663219
Ann Thorac Surg. 2009 Apr;87(4):1048-54; discussion 1054-5
pubmed: 19324126
Tumour Biol. 2014 Dec;35(12):12245-53
pubmed: 25195131
Br J Cancer. 2011 Mar 15;104(6):893-8
pubmed: 21364594
Int J Cancer. 2014 Sep 1;135(5):1011-8
pubmed: 24166096
J Cancer. 2018 Jul 30;9(16):2876-2884
pubmed: 30123356
Clin Transl Gastroenterol. 2018 Nov 13;9(11):203
pubmed: 30420592
Oncotarget. 2017 May 23;8(21):34468-34480
pubmed: 28380431
Int J Surg. 2018 Dec;60:41-47
pubmed: 30336280
Int J Cancer. 2010 Mar 1;126(5):1166-76
pubmed: 19676045
J Surg Oncol. 2012 Aug 1;106(2):188-92
pubmed: 22354855
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Gut Liver. 2021 Jul 15;15(4):553-561
pubmed: 33293482
Int J Clin Exp Pathol. 2018 Sep 01;11(9):4339-4345
pubmed: 31949830
Br J Cancer. 2013 May 14;108(9):1822-9
pubmed: 23579215
Clin Cancer Res. 2009 Oct 1;15(19):6192-200
pubmed: 19789312
Nature. 2005 Jun 9;435(7043):828-33
pubmed: 15944707
Dis Esophagus. 2017 Feb 1;30(2):1-9
pubmed: 27003597
J Biol Chem. 2010 Jun 4;285(23):17442-52
pubmed: 20353945
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Oncology. 2007;72(5-6):397-402
pubmed: 18196926
RNA. 2008 Nov;14(11):2348-60
pubmed: 18812439
Cancer Res. 2010 Mar 1;70(5):1906-15
pubmed: 20179198
Br J Cancer. 2011 Mar 1;104(5):830-40
pubmed: 21326242
J Gastroenterol Hepatol. 2019 Mar;34(3):552-560
pubmed: 30426559
Clin Chem. 2015 Sep;61(9):1138-55
pubmed: 26319452
Eur Arch Otorhinolaryngol. 2019 Apr;276(4):957-968
pubmed: 30747316
Dis Esophagus. 2016 Jul;29(5):412-20
pubmed: 25789723
Oncol Lett. 2017 Nov;14(5):5631-5637
pubmed: 29142608
Lancet Oncol. 2012 Jun;13(6):e249-58
pubmed: 22652233
BMC Cancer. 2020 May 5;20(1):377
pubmed: 32370743
Clin Cancer Res. 2009 Apr 15;15(8):2850-5
pubmed: 19351747
Gut Liver. 2019 Feb 27;13(4):394-401
pubmed: 30970448
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Tumour Biol. 2014 Dec;35(12):11995-2004
pubmed: 25159040
Clin Sci (Lond). 2011 Nov;121(10):437-47
pubmed: 21658006
J Clin Invest. 2010 Apr;120(4):1298-309
pubmed: 20237410
Br J Cancer. 2011 Jun 28;105(1):104-11
pubmed: 21673684
Nat Rev Genet. 2008 Feb;9(2):102-14
pubmed: 18197166
Cell. 2005 Jan 14;120(1):15-20
pubmed: 15652477
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Tumour Biol. 2014 Dec;35(12):12635-43
pubmed: 25213696
Med Oncol. 2010 Sep;27(3):685-9
pubmed: 19598010
Clin Chim Acta. 2008 Mar;389(1-2):61-6
pubmed: 18155162
Tumour Biol. 2015 Mar;36(3):1973-81
pubmed: 25527152
Mol Biol Rep. 2014 Mar;41(3):1257-66
pubmed: 24390317
Biologics. 2019 Jun 11;13:101-110
pubmed: 31354238
Cancer Res. 2005 Jul 15;65(14):6029-33
pubmed: 16024602
Gut. 2012 Jan;61(1):33-42
pubmed: 21813472