The Specificity of ParR Binding Determines the Incompatibility of Conjugative Plasmids in Clostridium perfringens.
Clostridium perfringens
DNA binding
ParR
analytical ultracentrifugation
parC
plasmid incompatibility
plasmid maintenance
plasmid partitioning
surface plasmon resonance
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
30 08 2022
30 08 2022
Historique:
pubmed:
22
6
2022
medline:
3
9
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
Plasmids that encode the same replication machinery are generally unable to coexist in the same bacterial cell. However, Clostridium perfringens strains often carry multiple conjugative toxin or antibiotic resistance plasmids that are closely related and encode similar Rep proteins. In many bacteria, plasmid partitioning upon cell division involves a ParMRC system; in C. perfringens plasmids, there are approximately 10 different ParMRC families, with significant differences in amino acid sequences between each ParM family (15% to 54% identity). Since plasmids carrying genes belonging to the same ParMRC family are not observed in the same strain, these families appear to represent the basis for plasmid compatibility in C. perfringens. To understand this process, we examined the key recognition steps between ParR DNA-binding proteins and their
Identifiants
pubmed: 35726914
doi: 10.1128/mbio.01356-22
pmc: PMC9426499
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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