Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 07 2022
Historique:
pubmed: 22 6 2022
medline: 16 7 2022
entrez: 21 6 2022
Statut: ppublish

Résumé

With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.

Identifiants

pubmed: 35727231
doi: 10.1021/acs.jmedchem.2c00611
pmc: PMC10152543
mid: NIHMS1892919
doi:

Substances chimiques

Antimalarials 0
Artemisinins 0
Peptides 0
Proteasome Inhibitors 0
Protozoan Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

9350-9375

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI143714
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123794
Pays : United States

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Auteurs

Hao Zhang (H)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

John Ginn (J)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Wenhu Zhan (W)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

Yi J Liu (YJ)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

Annie Leung (A)

Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

Akinori Toita (A)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Rei Okamoto (R)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Tzu-Tshin Wong (TT)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Toshihiro Imaeda (T)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Ryoma Hara (R)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Takafumi Yukawa (T)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Mayako Michino (M)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Jeremie Vendome (J)

Schrödinger, Inc., New York, New York 10036, United States.

Thijs Beuming (T)

Schrödinger, Inc., New York, New York 10036, United States.

Kenjiro Sato (K)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Kazuyoshi Aso (K)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Peter T Meinke (PT)

Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States.

Carl F Nathan (CF)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

Laura A Kirkman (LA)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

Gang Lin (G)

Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.

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Classifications MeSH