Methylation of alpha-synuclein in a Sudanese cohort.

Adolescent Adult DNA DNA Methylation / genetics Epigenesis, Genetic Humans Middle Aged Parkinson Disease / genetics Young Adult alpha-Synuclein / genetics
Methylation Parkinson's disease SNCA Sudan

Journal

Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583

Informations de publication

Date de publication:
08 2022
Historique:
received: 01 02 2022
revised: 02 05 2022
accepted: 10 05 2022
pubmed: 22 6 2022
medline: 24 8 2022
entrez: 21 6 2022
Statut: ppublish

Résumé

Several studies suggested a significant role of epigenetic changes, including alterations in miRNA, histone modifications, and DNA methylation of α-synuclein (SNCA) in Parkinson's disease (PD) pathogenicity. As of yet, only very few studies have been carried out in this field in Africa and none in Sudan. We collected DNA from 172 Sudanese individuals (90 cases, 82 controls) who donated saliva for DNA extraction (mean age of onset: 40.6 ± 22.4 years). A family history of PD was evident in 64 patients. DNA preparation and bisulfite sequencing of SNCA Of the fourteen analyzed CpGs of SNCA We identified the presence of a specific pattern of DNA methylation in a young Sudanese cohort of familial PD, which confirms the importance of the methylation of SNCA

Sections du résumé

BACKGROUND
Several studies suggested a significant role of epigenetic changes, including alterations in miRNA, histone modifications, and DNA methylation of α-synuclein (SNCA) in Parkinson's disease (PD) pathogenicity. As of yet, only very few studies have been carried out in this field in Africa and none in Sudan.
MATERIALS AND METHODS
We collected DNA from 172 Sudanese individuals (90 cases, 82 controls) who donated saliva for DNA extraction (mean age of onset: 40.6 ± 22.4 years). A family history of PD was evident in 64 patients. DNA preparation and bisulfite sequencing of SNCA
RESULTS
Of the fourteen analyzed CpGs of SNCA
CONCLUSION
We identified the presence of a specific pattern of DNA methylation in a young Sudanese cohort of familial PD, which confirms the importance of the methylation of SNCA

Identifiants

DOI: 10.1016/j.parkreldis.2022.05.009 PMID: 35728367
pubmed: 35728367
pii: S1353-8020(22)00137-7
doi: 10.1016/j.parkreldis.2022.05.009
pii:
doi:

Substances chimiques

SNCA protein, human 0
alpha-Synuclein 0
DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6-8

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Yousuf Bakhit (Y)

Department of Neurology, University Hospital Bonn, Germany; Department of Basic Medical Sciences, Faculty of Dentistry, University of Khartoum, Sudan; Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan. Electronic address: npgy1@yahoo.com.

Ina Schmitt (I)

Department of Neurology, University Hospital Bonn, Germany.

Ahlam Hamed (A)

Department of Paediatrics, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Etedal Ahmed A Ibrahim (EAA)

Faculty of Medicine, Al Neelain University, Khartoum, Sudan, and The National Centre for Neurological Sciences, Sudan.

Inaam N Mohamed (IN)

Department of Paediatrics, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Sarah M El-Sadig (SM)

Department of Neurology, Soba Teaching Hospital, And Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Maha A Elseed (MA)

Department of Paediatrics, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Mohamed A Alebeed (MA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Mutaz T Shaheen (MT)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Mohamed O Ibrahim (MO)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan; Department of Biochemistry, Faculty of Medicine, Sudan University of Science and Technology, Khartoum, Sudan.

Ali A Elhassan (AA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Khalid Eltom (K)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Hiba A Ali (HA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Yousuf A Ibrahim (YA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Murad E Almak (ME)

Department of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Rayan Abubaker (R)

Department of Molecular Medicine, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan; Department of Molecular Biology, National University Biomedical Research Institute (NUBRI), National University, Khartoum, Sudan.

Mohamed Anwer Ahmed (MA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Ahmed A Abugrain (AA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Salma M Elrasheed (SM)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Mawia A Omar (MA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Mohamed A Almahal (MA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Abubaker A MohamedSharif (AA)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan; Department of Anatomy, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Mohamed Y Tahir (MY)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Sawazen M Malik (SM)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Hazim S Eldirdiri (HS)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan; University of Bordeaux, INSERM, U1215, Neurocentre Magendie, Bordeaux, France.

Reem J Khidir (RJ)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Malaz T Mohamed (MT)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Abdelmohaymin Abdalla (A)

Sudan Neuroscience Projects, University of Khartoum, Khartoum, Sudan.

Farouk Yassen Omer (FY)

Department of Medicine, Neurology, Omdurman Islamic University, Khartoum, Sudan.

Liena E O Elsayed (LEO)

Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Haydar El Hadi Babikir (HEH)

Department of Paediatrics and Child Health, Faculty of Medicine, University of Gezira, Sudan.

Elfateh Abd-Allah Bukhari (EA)

Department of Neurology, Bashaier University Hospital, And Khartoum Teaching Hospital. Department of Medicine, Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.

Osheik Seidi (O)

Department of Neurology, Soba Teaching Hospital, And Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Ullrich Wüllner (U)

Department of Neurology, University Hospital Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address: ullrich.wuellner@dzne.de.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Methylation of alpha-synuclein in a Sudanese cohort.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Methylation of alpha-synuclein in a Sudanese cohort.