Development of cVSSI-APCI for the Improvement of Ion Suppression and Matrix Effects in Complex Mixtures.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
05 07 2022
05 07 2022
Historique:
pubmed:
22
6
2022
medline:
8
7
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
The new ionization technique termed vibrating sharp-edge spray ionization (cVSSI) has been coupled with corona discharge to investigate atmospheric pressure chemical ionization (APCI) capabilities. The optimized source was evaluated for its ability to enhance ion signal intensity, overcome matrix effects, and limit ion suppression. The results have been compared with state-of-the-art ESI source performance as well as a new APCI-like source. In methanol, the ion signal intensity increased 10-fold and >10-fold for cocaine and the suppressed analytes, respectively. The ability to overcome ion suppression was improved from 2-fold to 16-fold for theophylline and vitamin D2, respectively. For aqueous samples, ion signal levels increased by two orders of magnitude for all analytes. In both solvent systems, the signal-to-noise ratios also increased for all suppressed analytes. One example of the characterization of low-ionizing (by ESI or cVSSI alone) species in the presence of high-ionizing species by direct analysis from a cotton swab is presented. The work is discussed with respect to the advantages of cVSSI-APCI for direct, in situ, and field analyses.
Identifiants
pubmed: 35729103
doi: 10.1021/acs.analchem.1c05136
pmc: PMC9260805
mid: NIHMS1820821
doi:
Substances chimiques
Complex Mixtures
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
9226-9233Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM135432
Pays : United States
Références
J Am Soc Mass Spectrom. 2005 Aug;16(8):1207-20
pubmed: 15979338
Biochim Biophys Acta. 2011 Nov;1811(11):961-9
pubmed: 21440085
Anal Chem. 2019 Sep 17;91(18):11562-11568
pubmed: 31449396
Anal Chem. 2020 Aug 18;92(16):11072-11079
pubmed: 32662994
Mass Spectrom Rev. 2006 Nov-Dec;25(6):881-99
pubmed: 16783795
Phytochem Rev. 2016;15:445-488
pubmed: 27340381
Bioanalysis. 2013 Oct;5(19):2331-2
pubmed: 24066616
Anal Methods. 2020 Oct 22;12(40):4831-4852
pubmed: 33000770
J Am Soc Mass Spectrom. 2019 Jun;30(6):1102-1114
pubmed: 30980382
Sci Rep. 2019 Jul 16;9(1):10296
pubmed: 31311939
Anal Chem. 2003 Jul 1;75(13):3019-30
pubmed: 12964746
J Am Soc Mass Spectrom. 2019 May;30(5):824-831
pubmed: 30793264
Adv Virus Res. 2017;98:57-81
pubmed: 28433052
J Am Soc Mass Spectrom. 1996 Nov;7(11):1099-105
pubmed: 24203071
Mass Spectrom Rev. 2009 Nov-Dec;28(6):870-97
pubmed: 19626583
Anal Chem. 2019 Jan 2;91(1):912-918
pubmed: 30481449
J Am Soc Mass Spectrom. 2008 Oct;19(10):1527-34
pubmed: 18657438
Anal Chem. 2021 Jun 1;93(21):7549-7556
pubmed: 34008955
Anal Chem. 1998 Mar 1;70(5):882-9
pubmed: 9511465
Anal Chem. 2015 Jul 7;87(13):6786-93
pubmed: 26024306
J Biosci. 2018 Sep;43(4):731-738
pubmed: 30207318
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:119-28
pubmed: 24548922
Anal Chem. 1975 Jul;47(8):1308-12
pubmed: 807126
Clin Chem. 2016 Jan;62(1):99-110
pubmed: 26467505
J Am Soc Mass Spectrom. 2015 Sep;26(9):1502-7
pubmed: 26091890
Methods. 2005 Mar;35(3):211-22
pubmed: 15722218
Anal Chem. 2020 Feb 4;92(3):2492-2502
pubmed: 31940176
Cell Metab. 2007 Nov;6(5):348-51
pubmed: 17983580
Anal Chem. 2018 Jan 2;90(1):240-265
pubmed: 29155564
Faraday Discuss. 2019 Aug 15;218(0):29-51
pubmed: 31184658
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 15;1079:51-61
pubmed: 29444490
Mol Cell Proteomics. 2010 Feb;9(2):362-7
pubmed: 19955086
Anal Bioanal Chem. 2016 Feb;408(5):1453-65
pubmed: 26780707
Curr Opin Struct Biol. 2002 Dec;12(6):729-34
pubmed: 12504676
Int J Mass Spectrom. 2015 Feb 1;377:719-717
pubmed: 25844058
J Mass Spectrom. 2010 Mar;45(3):252-60
pubmed: 20020414
J Am Soc Mass Spectrom. 2021 Feb 3;32(2):473-485
pubmed: 33417454
J Proteome Res. 2008 Mar;7(3):1007-11
pubmed: 18247544
Nat Biotechnol. 2001 Mar;19(3):242-7
pubmed: 11231557
Analyst. 2017 Aug 21;142(17):3101-3117
pubmed: 28792022
Anal Bioanal Chem. 2015 Jul;407(17):4971-2
pubmed: 25963650
Metabolomics. 2019 Oct 4;15(10):135
pubmed: 31584114
Hortic Res. 2021 Jul 1;8(1):160
pubmed: 34193823
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 1;877(23):2198-207
pubmed: 19179125
Rapid Commun Mass Spectrom. 2019 Jul;33 Suppl 3:96-120
pubmed: 30138957
Analyst. 2008 Oct;133(10):1297-301
pubmed: 18810277
Analyst. 2016 Jun 21;141(12):3811-20
pubmed: 26979768
Methods Enzymol. 2005;402:245-89
pubmed: 16401512
Anal Chem. 2017 Jan 3;89(1):372-388
pubmed: 28105828
Rapid Commun Mass Spectrom. 2021 Jan;35 Suppl 1:e8232
pubmed: 29993155
Rapid Commun Mass Spectrom. 2003;17(1):97-103
pubmed: 12478560
Rapid Commun Mass Spectrom. 2020 Apr 30;34(8):e8676
pubmed: 31773793
Rapid Commun Mass Spectrom. 2013 Jul 15;27(13):1429-36
pubmed: 23722677
Anal Bioanal Chem. 2018 Jul;410(17):4061-4076
pubmed: 29700557
Curr Opin Biotechnol. 2015 Feb;31:24-34
pubmed: 25146170
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):22-34
pubmed: 17236825
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18090-5
pubmed: 18836082
J Am Soc Mass Spectrom. 2021 Jan 6;32(1):84-94
pubmed: 32856909
Lipids. 2001 Apr;36(4):327-46
pubmed: 11383683
J Inherit Metab Dis. 2015 Jan;38(1):41-52
pubmed: 25409862
Anal Chem. 2009 Nov 1;81(21):9146-52
pubmed: 19817477
Mass Spectrom Rev. 2007 Jul-Aug;26(4):606-43
pubmed: 17471576
Sci Transl Med. 2017 Sep 6;9(406):
pubmed: 28878011
J Am Soc Mass Spectrom. 2009 Apr;20(4):584-92
pubmed: 19112027
Curr Opin Chem Biol. 2008 Oct;12(5):483-90
pubmed: 18718552