Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients' breath.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 06 2022
21 06 2022
Historique:
received:
27
12
2021
accepted:
29
04
2022
entrez:
21
6
2022
pubmed:
22
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Several studies highlighted a correlation between exhaled air volatile organic compounds (VOCs) and some pathological conditions, such as chronic kidney disease (CKD), chronic liver disease, etc. In fact, in literature has been reported that CKD is characterized by an increased concentration of ammonia, trimethylamine (TMA) and isoprene compared to healthy subjects. Currently, there is not a validate and standardized method to detect VOCs. For this purpose, we examined the utility of selected ion flow tube-mass spectrometry (SIFT-MS) to measure VOCs in CKD patients and we evaluated the possible correlation between VOCs and the presence of CKD and its stage. We enrolled 68 CKD patients under conservative therapy and 54 healthy subjects. The analysis of the VOCs of the exhaled air of the enrolled subjects was performed by SIFT-MS. Among all the VOCs analyzed, the most relevant results by ROC curves were observed for TMA, acetone, ammonia and dimethyl sulfide. We found that a breath TMA concentration superior to 26 ppbv characterizes a 6.11 times greater risk of CKD, compared to subjects with lower levels. Moreover, we detected an increased concentration of acetone and ammonia in CKD patients compared to healthy subjects. We highlight the potential utility of SIFT-MS in CKD clinical management.Clinical trial registry: R.S. 15.19 of 6 February 2019.
Identifiants
pubmed: 35729207
doi: 10.1038/s41598-022-14152-7
pii: 10.1038/s41598-022-14152-7
pmc: PMC9428186
doi:
Substances chimiques
Volatile Organic Compounds
0
Acetone
1364PS73AF
Ammonia
7664-41-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10413Informations de copyright
© 2022. The Author(s).
Références
Biomed Chromatogr. 2007 Jun;21(6):553-66
pubmed: 17431933
Gene. 2009 Apr 15;435(1-2):96-103
pubmed: 19393179
Patient Prefer Adherence. 2018 Apr 19;12:577-583
pubmed: 29720873
Rapid Commun Mass Spectrom. 2006;20(1):61-8
pubmed: 16312013
Biochem J. 2009 Oct 23;424(1):99-107
pubmed: 19740075
Lung. 2002;180(3):149-59
pubmed: 12177729
Rapid Commun Mass Spectrom. 2014 Jan 15;28(1):10-8
pubmed: 24285385
Science. 1988 Mar 4;239(4844):1147-50
pubmed: 2449733
Annu Rev Anal Chem (Palo Alto Calif). 2014;7:455-82
pubmed: 25014347
Isr Med Assoc J. 2001 Feb;3(2):131-6
pubmed: 11344824
JCI Insight. 2021 Aug 9;6(15):
pubmed: 34228649
PLoS One. 2017 Jun 1;12(6):e0178745
pubmed: 28570715
Aging (Albany NY). 2018 Mar 27;10(3):425-433
pubmed: 29615540
Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S66-70
pubmed: 11158865
Kidney Int. 1997 Jul;52(1):223-8
pubmed: 9211367
Pharmacol Res. 2021 Jan;163:105273
pubmed: 33197599
Cell Death Dis. 2012 Aug 23;3:e377
pubmed: 22914325
Front Nutr. 2020 Aug 21;7:120
pubmed: 32974376
Nutrients. 2019 Jul 27;11(8):
pubmed: 31357662
J Breath Res. 2018 Jan 03;12(2):027102
pubmed: 28972201
Kidney Int. 2017 Oct;92(4):809-815
pubmed: 28807612
Klin Wochenschr. 1981 May 4;59(9):431-6
pubmed: 7278085
iScience. 2022 Jan 06;25(2):103739
pubmed: 35141500
J Nephrol. 2015 Oct;28(5):571-6
pubmed: 25095762
Toxins (Basel). 2019 Nov 01;11(11):
pubmed: 31683880
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):455-60
pubmed: 21681085
J Breath Res. 2014 Sep;8(3):036003
pubmed: 25080054
Bioanalysis. 2014 Mar;6(6):843-57
pubmed: 24702114
Circ Res. 2015 Jan 30;116(3):448-55
pubmed: 25599331
Nephrol Dial Transplant. 2006 May;21(5):1300-4
pubmed: 16401621
J Ren Nutr. 2015 Jul;25(4):351-6
pubmed: 25802017
J Nephrol. 2014 Oct;27(5):529-36
pubmed: 24711158
Kidney Int. 1992 May;41(5):1286-91
pubmed: 1614043
Nephrol Dial Transplant. 2001 Apr;16(4):836-9
pubmed: 11274283
PLoS One. 2020 May 29;15(5):e0233331
pubmed: 32469929
J Am Soc Nephrol. 2016 Jan;27(1):305-13
pubmed: 26229137
Clin Exp Nephrol. 2019 Feb;23(2):251-257
pubmed: 30121801
N Engl J Med. 1977 Jul 21;297(3):132-5
pubmed: 865584
Dig Dis Sci. 2005 Oct;50(10):1780-4
pubmed: 16187173
Oxid Med Cell Longev. 2018 Dec 23;2018:3704129
pubmed: 30671169
Physiol Rev. 2014 Jan;94(1):1-34
pubmed: 24382882
Int J Immunopathol Pharmacol. 2015 Mar;28(1):129-33
pubmed: 25816416
Cell Death Discov. 2016 May 09;2:16026
pubmed: 27551517
Crit Care Med. 2016 Jul;44(7):e544-52
pubmed: 26757166
PLoS One. 2012;7(9):e46258
pubmed: 23049998
Cell Death Dis. 2018 Feb 19;9(3):288
pubmed: 29459773
J Breath Res. 2017 Jun 12;11(2):026009
pubmed: 28473668
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Science. 1988 Jun 3;240(4857):1285-93
pubmed: 3287615
Crit Care Med. 2008 Apr;36(4 Suppl):S229-37
pubmed: 18382199
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
N Engl J Med. 2013 Apr 25;368(17):1575-84
pubmed: 23614584
Clin Chim Acta. 2021 Apr;515:61-72
pubmed: 33387463