Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Cleft lip
Cleft palate
Congenital abnormalities
Craniofacial abnormalities
Tooth abnormalities
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
05
11
2021
accepted:
05
05
2022
pubmed:
22
6
2022
medline:
19
8
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
To evaluate the association between orofacial clefts (OFC) and tooth abnormalities (TA). We searched PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and BBO, and in the gray literature and selected observational studies that evaluated the association between TA and OFC. The risk of bias was analyzed using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed comparing the presence and absence of OFC, cleft type-cleft palate (CP) and cleft lip with or without palate (CL/P)-and cleft laterality-unilateral and bilateral. The certainty of evidence was evaluated using the GRADE approach. A total of 99 studies were included in the qualitative analysis, and 37 were included in the meta-analysis. Only four studies were classified as low risk of bias. Significant associations were observed between the presence of OFC and tooth agenesis (OR = 19.46; 95%CI = 4.99-75.96), supernumerary teeth (OR = 4.04; 95%CI = 1.26-12.99), developmental defects of enamel (OR = 3.15; 95%CI = 1.28-7.80), microdontia (OR = 15.57; 95%CI = 1.06-228.51), and taurodontism (OR = 1.74; 95%CI = 1.74-2.86). Individuals with CP had a lower frequency of supernumerary teeth (OR = 0.22; 95%CI = 0.08-0.64), peg-shaped tooth (OR = 0.31; 95%CI = 0.12-0.80), and morphological TA (OR = 0.13; 95%CI = 0.04-0.45) than individuals with CL/P. No TA was significantly associated with cleft laterality (p > 0.05). The quality of the evidence was very low in all analyses. Individuals with OFC had a higher frequency of TA than those without OFC. Individuals with CP had a lower frequency of TA than individuals with CL/P. No TA was associated to cleft laterality. Help to identify the treatment needs of individuals affected by OFC, improving the services provided to this population.
Identifiants
pubmed: 35729285
doi: 10.1007/s00784-022-04540-8
pii: 10.1007/s00784-022-04540-8
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Pagination
5089-5103Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Bernheim N, Georges M, Malevez C, De Mey A, Mansbach A (2006) Embryology and epidemiology of cleft lip and palate. B-ENT 2(Suppl 4):11–19
pubmed: 17366840
Panamonta V, Pradubwong S, Panamonta M, Chowchuen B (2015) Global birth prevalence of orofacial clefts: a systematic review. J Med Assoc Thai 98(Suppl 7):S11-21
pubmed: 26742364
Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC (2009) Cleft lip and palate. Lancet 374:1773–1785. https://doi.org/10.1016/s0140-6736(09)60695-4
doi: 10.1016/s0140-6736(09)60695-4
pubmed: 19747722
Rodrigues R, Fernandes MH, Monteiro AB, Furfuro R, Sequeira T, Silva CC et al (2018) SPINA classification of cleft lip and palate: a suggestion for a complement. Arch Pediatr 25:439–441. https://doi.org/10.1016/j.arcped.2018.08.001
doi: 10.1016/j.arcped.2018.08.001
pubmed: 30249490
Leslie EJ, Marazita ML (2013) Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet 163c:246–58. https://doi.org/10.1002/ajmg.c.31381
doi: 10.1002/ajmg.c.31381
pubmed: 24124047
Mossey PA, Modell B (2012) Epidemiology of oral clefts 2012: an international perspective. Front Oral Biol 16:1–18. https://doi.org/10.1159/000337464
doi: 10.1159/000337464
pubmed: 22759666
Allori AC, Mulliken JB, Meara JG, Shusterman S, Marcus JR (2017) Classification of cleft lip/palate: then and now. Cleft Palate Craniofac J 54:175–188. https://doi.org/10.1597/14-080
doi: 10.1597/14-080
pubmed: 26339868
Cakan DG, Yilmaz RBN, Bulut FN, Aksoy A (2018) Dental anomalies in different types of cleft lip and palate: is there any relation? J Craniofac Surg 29:1316–1321. https://doi.org/10.1097/scs.0000000000004359
doi: 10.1097/scs.0000000000004359
Howe BJ, Cooper ME, Vieira AR, Weinberg SM, Resick JM, Nidey NL et al (2015) Spectrum of dental phenotypes in nonsyndromic orofacial clefting. J Dent Res 94:905–912. https://doi.org/10.1177/0022034515588281
doi: 10.1177/0022034515588281
pubmed: 26082386
pmcid: 4530345
Kuchler EC, da Motta LG, Vieira AR, Granjeiro JM (2011) Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. Cleft Palate Craniofac J 48:103–108. https://doi.org/10.1597/09-159
doi: 10.1597/09-159
pubmed: 20507240
Lavôr JR, Lacerda RHW, Modesto A, Vieira AR (2020) Maxillary incisor enamel defects in individuals born with cleft lip/palate. PLoS ONE 15:e0244506. https://doi.org/10.1371/journal.pone.0244506
doi: 10.1371/journal.pone.0244506
pubmed: 33370403
pmcid: 7769421
Letra A, Menezes R, Granjeiro JM, Vieira AR (2007) Defining subphenotypes for oral clefts based on dental development. J Dent Res 86:986–991. https://doi.org/10.1177/154405910708601013
doi: 10.1177/154405910708601013
pubmed: 17890676
Menezes R, Vieira AR (2008) Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J 45:414–419. https://doi.org/10.1597/07-064.1
doi: 10.1597/07-064.1
pubmed: 18616370
Nicholls W (2016) Dental anomalies in children with cleft lip and palate in Western Australia. Eur J Dent 10:254–258. https://doi.org/10.4103/1305-7456.178317
doi: 10.4103/1305-7456.178317
pubmed: 27095907
pmcid: 4813446
Yezioro-Rubinsky S, Eslava-Schmalbach JH, Otero L, Rodriguez-Aguirre SA, Duque AM, Campos FM et al (2020) Dental Anomalies in Permanent Teeth Associated With Nonsyndromic Cleft Lip and Palate in a Group of Colombian Children. Cleft Palate Craniofac J 57:73–79. https://doi.org/10.1177/1055665619861498
doi: 10.1177/1055665619861498
pubmed: 31284730
Mangione F, Nguyen L, Foumou N, Bocquet E, Dursun E (2018) Cleft palate with/without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region. Clin Oral Investig 22:689–695. https://doi.org/10.1007/s00784-017-2141-z
doi: 10.1007/s00784-017-2141-z
pubmed: 28589475
Al Jamal GA, Hazza’a AM, Rawashdeh MA (2010) Prevalence of dental anomalies in a population of cleft lip and palate patients. Cleft Palate Craniofac J 47:413–420. https://doi.org/10.1597/08-275.1
doi: 10.1597/08-275.1
pubmed: 20590463
Navas-Aparicio MDC (2017) Prevalencia de dientes supernumerarios en pacientes con labio y paladar hendido mediante el análisis de ortopantomografías. Rev Esp Cir Oral Maxilofac 39:171–178. https://doi.org/10.1016/j.maxilo.2016.03.004
doi: 10.1016/j.maxilo.2016.03.004
Eslami N, Majidi MR, Aliakbarian M, Hasanzadeh N (2013) Prevalence of dental anomalies in patients with cleft lip and palate. J Craniofac Surg 24:1695–1698. https://doi.org/10.1097/SCS.0b013e3182801bc8
doi: 10.1097/SCS.0b013e3182801bc8
pubmed: 24036756
Melo Filho MR, Nogueira dos Santos LA, Barbosa Martelli DR, Silveira MF, Esteves da Silva M, de Barros LM et al (2015) Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol 120:744–750. https://doi.org/10.1016/j.oooo.2015.08.005
doi: 10.1016/j.oooo.2015.08.005
pubmed: 26428895
Weckwerth GM, Santos CF, Brozoski DT, Centurion BS, Pagin O, Lauris JR et al (2016) Taurodontism, root dilaceration, and tooth transposition: a radiographic study of a population with nonsyndromic cleft lip and/or palate. Cleft Palate Craniofac J 53:404–412. https://doi.org/10.1597/14-299
doi: 10.1597/14-299
pubmed: 26247709
Shen CA, Guo R, Li W (2019) Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study. J Int Med Res 47:2084–2096. https://doi.org/10.1177/0300060519832165
doi: 10.1177/0300060519832165
pubmed: 30913937
pmcid: 6567767
Heliovaara A, Ranta R, Rautio J (2004) Dental abnormalities in permanent dentition in children with submucous cleft palate. Acta Odontol Scand 62:129–131. https://doi.org/10.1080/00016350410006572
doi: 10.1080/00016350410006572
pubmed: 15370630
Bartzela TN, Carels CE, Bronkhorst EM, Kuijpers-Jagtman AM (2013) Tooth agenesis patterns in unilateral cleft lip and palate in humans. Arch Oral Biol 58:596–602. https://doi.org/10.1016/j.archoralbio.2012.12.007
doi: 10.1016/j.archoralbio.2012.12.007
pubmed: 23295124
Qureshi WA, Beiraghi S, Leon-Salazar V (2012) Dental anomalies associated with unilateral and bilateral cleft lip and palate. J Dent Child 79:69–73
Rullo R, Festa VM, Rullo R, Addabbo F, Chiodini P, Vitale M et al (2015) Prevalence of dental anomalies in children with cleft lip and unilateral and bilateral cleft lip and palate. Eur J Paediatr Dent 16:229–232
pubmed: 26418927
American Academy of Pediatric Dentistry (2021) Policy on the management of patients with cleft lip/palate and other craniofacial anomalies. The Reference Manual of Pediatric Dentistry. Chicago, Ill. American Academy of Pediatric Dentistry:539–40
Cassolato SF, Ross B, Daskalogiannakis J, Noble J, Tompson B, Paedo D (2009) Treatment of dental anomalies in children with complete unilateral cleft lip and palate at SickKids hospital, Toronto. Cleft Palate Craniofac J 46:166–172. https://doi.org/10.1597/07-239.1
doi: 10.1597/07-239.1
pubmed: 19254064
Lewis C, Jacob LS, Lehmann CU (2017) AAP section on oral health. The Primary Care Pediatrician and the Care of Children With Cleft Lip and/or Cleft Palate. Pediatr 139:e20170628. https://doi.org/10.1542/peds.2017-1921
doi: 10.1542/peds.2017-1921
Rodrigues R, Fernandes MH, Bessa Monteiro A, Furfuro R, Carvalho Silva C, Vardasca R et al (2019) Are there any solutions for improving the cleft area hygiene in patients with cleft lip and palate? A systematic review. Int J Dent Hyg 17:130–141. https://doi.org/10.1111/idh.12385
doi: 10.1111/idh.12385
pubmed: 30697916
Marzouk T, Alves IL, Wong CL, DeLucia L, McKinney CM, Pendleton C, et al (2020) Association between dental anomalies and orofacial clefts: a meta-analysis. JDR Clin Trans Res:2380084420964795. https://doi.org/10.1177/2380084420964795
Tannure PN, Oliveira CA, Maia LC, Vieira AR, Granjeiro JM, Costa Mde C (2012) Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J 49:194–200. https://doi.org/10.1597/10-043
doi: 10.1597/10-043
pubmed: 21740173
Booth A, Clarke M, Dooley G, Ghersi D, Moher D, Petticrew M et al (2012) The nuts and bolts of PROSPERO: an international prospective register of systematic reviews. Syst Rev 1:2. https://doi.org/10.1186/2046-4053-1-2
doi: 10.1186/2046-4053-1-2
pubmed: 22587842
pmcid: 3348673
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71
doi: 10.1136/bmj.n71
pubmed: 33782057
pmcid: 8005924
Wells G, Shea B, O'Connell D, Peterson j, Welch V, Losos M, et al. (2019) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. The Ottawa Hospital Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp . Accessed 8 Mar 2021
Deps TD, Angelo GL, Martins CC, Paiva SM, Pordeus IA, Borges-Oliveira AC (2015) Association between dental caries and down syndrome: a systematic review and meta-analysis. PLoS ONE 10:e0127484. https://doi.org/10.1371/journal.pone.0127484
doi: 10.1371/journal.pone.0127484
pubmed: 26086498
pmcid: 4472226
Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605. https://doi.org/10.1007/s10654-010-9491-z
doi: 10.1007/s10654-010-9491-z
pubmed: 20652370
Meta-Analysis Workshops (2021) Common mistakes in meta-analysis and how to avoid them fixed-effect vs. random-effects. Meta-Analysis Workshops. https://www.meta-analysis-workshops.com/pages/paperseries.php . Accessed 9 Mar 2021
Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2. Cochrane. https://www.training.cochrane.org/handbook . Accessed 3 Mar 2021
Moccelini BS, de Alencar NA, Bolan M, Magno MB, Maia LC, Cardoso M (2018) Pulp necrosis and crown discoloration: a systematic review and meta-analysis. Int J Paediatr Dent. https://doi.org/10.1111/ipd.12372
doi: 10.1111/ipd.12372
pubmed: 29896799
Schünemann H, Brożek J, Guyatt G and Oxman A (2013) GRADE handbook for grading quality of evidence and strength of recommendations. The GRADE Working Group. https://gdt.gradepro.org/app/handbook/handbook.html . Accessed 9 Mar 2021
GRADEpro (2020) GDT: GRADEpro Guideline Development Tool. McMaster University. https://www.gradepro.org . Accessed 9 Mar 2021
Dahllof G, Ussisoo-Joandi R, Ideberg M, Modeer T (1989) Caries, gingivitis, and dental abnormalities in preschool children with cleft lip and/or palate. Cleft Palate J 26:233–7 (discussion 237-8)
pubmed: 2788042
Lehtonen V, Anttonen V, Ylikontiola LP, Koskinen S, Pesonen P, Sandor GK (2015) Dental anomalies associated with cleft lip and palate in Northern Finland. Eur J Paediatr Dent 16:327–332
pubmed: 26637260
Suzuki A, Nakano M, Yoshizaki K, Yasunaga A, Haruyama N, Takahashi I (2017) A longitudinal study of the presence of dental anomalies in the primary and permanent dentitions of cleft lip and/or palate patients. Cleft Palate Craniofac J 54:309–320. https://doi.org/10.1597/15-186
doi: 10.1597/15-186
pubmed: 27031269
Aizenbud D, Camasuvi S, Peled M, Brin I (2005) Congenitally missing teeth in the Israeli cleft population. Cleft Palate Craniofac J 42:314–317. https://doi.org/10.1597/03-126.1
doi: 10.1597/03-126.1
pubmed: 15865468
Aizenbud D, Coval M, Hazan-Molina H, Harari D (2011) Isolated soft tissue cleft lip: epidemiology and associated dental anomalies. Oral Dis 17:221–231. https://doi.org/10.1111/j.1601-0825.2010.01729.x
doi: 10.1111/j.1601-0825.2010.01729.x
pubmed: 20796225
Akcam MO, Evirgen S, Uslu O, Memikoglu UT (2010) Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod 32:207–213. https://doi.org/10.1093/ejo/cjp156
doi: 10.1093/ejo/cjp156
pubmed: 20335565
Al-Kharboush GH, Al-Balkhi KM, Al-Moammar K (2015) The prevalence of specific dental anomalies in a group of Saudi cleft lip and palate patients. Saudi Dent J 27:75–80. https://doi.org/10.1016/j.sdentj.2014.11.007
doi: 10.1016/j.sdentj.2014.11.007
pubmed: 26082573
pmcid: 4459076
Baek SH, Kim NY (2007) Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patients. Angle Orthod 77:88–93. https://doi.org/10.2319/113005-419r.1
doi: 10.2319/113005-419r.1
pubmed: 17029545
Bartzela TN, Carels CE, Bronkhorst EM, Ronning E, Rizell S, Kuijpers-Jagtman AM (2010) Tooth agenesis patterns in bilateral cleft lip and palate. Eur J Oral Sci 118:47–52. https://doi.org/10.1111/j.1600-0722.2009.00698.x
doi: 10.1111/j.1600-0722.2009.00698.x
pubmed: 20156264
Berniczei-Royko A, Tappe JH, Krinner A, Gredes T, Vegh A, Gabor K, et al (2016) Radiographic study of the prevalence and distribution of hypodontia associated with unilateral and bilateral clef lip and palate in a Hungarian population. Med Sci Monit 22:3868–3885. https://doi.org/10.12659/msm.897957
Carpentier S, Ghijselings E, Schoenaers J, Carels C, Verdonck A (2014) Enamel defects on the maxillary premolars in patients with cleft lip and/or palate: a retrospective case-control study. Eur Arch Paediatr Dent 15:159–165. https://doi.org/10.1007/s40368-013-0078-8
doi: 10.1007/s40368-013-0078-8
pubmed: 24101590
Celikoglu M, Buyuk SK, Sekerci AE, Cantekin K and Candirli C (2015) Maxillary dental anomalies in patients with cleft lip and palate: a cone beam computed tomography study. J Clin Pediatr Dent 39:183–6. https://doi.org/10.17796/jcpd.39.2.t623u7495h07522r
da Silva AP, Costa B, de Carvalho Carrara CF (2008) Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip: radiographic study. Cleft Palate Craniofac J 45:473–476. https://doi.org/10.1597/06-099.1
doi: 10.1597/06-099.1
pubmed: 18788864
de Lima PR, Faria MD, de Castro CM, Vieira AR (2012) Dental anomalies in children born with clefts: a case-control study. Cleft Palate Craniofac J 49:e64–e68. https://doi.org/10.1597/10-067
doi: 10.1597/10-067
De Stefani A, Bruno G, Balasso P, Mazzoleni S, Baciliero U, Gracco A (2019) Prevalence of hypodontia in unilateral and bilateral cleft lip and palate patients inside and outside cleft area: a case-control study. J Clin Pediatr Dent 43:126–130. https://doi.org/10.17796/1053-4625-43.2.10
Franco de Carvalho L, Tavano O (2008) Agenesias dentais em fissurados do Centro Pró-Sorriso - Universidade José do Rosário Vellano. Rev Gaucha Odontol 56:39–45
Haataja J, Haavikko K, Ranta R (1971) Hypodontia and supernumerary teeth in Finnish children affected with facial clefts. An orthopantomographic and clinical study. Suom Hammaslaak Toim 67:303–311
pubmed: 5290907
Jamilian A, Jamilian M, Darnahal A, Hamedi R, Mollaei M, Toopchi S (2015) Hypodontia and supernumerary and impacted teeth in children with various types of clefts. Am J Orthod Dentofacial Orthop 147:221–225. https://doi.org/10.1016/j.ajodo.2014.10.024
doi: 10.1016/j.ajodo.2014.10.024
pubmed: 25636556
Jamilian A, Showkatbakhsh R, Darnahal A, Baniasad N, Kamali Z (2015) Prevalence of dental anomalies in children with different types of cleft. Dent Med Probl 52:192–196
Jordan RE, Kraus BS, Neptune CM (1966) Dental abnormalities associated with cleft lip and/or palate. Cleft Palate J 3:22–55
pubmed: 5215935
Kraus BS, Jordan RE, Pruzansky S (1966) Dental abnormalities in the deciduous and permanent dentitions of individuals with cleft lip and palate. J Dent Res 45:1736–1746. https://doi.org/10.1177/00220345660450062601
doi: 10.1177/00220345660450062601
pubmed: 5226539
Lai MC, King NM, Wong HM (2009) Abnormalities of maxillary anterior teeth in Chinese children with cleft lip and palate. Cleft Palate Craniofac J 46:58–64. https://doi.org/10.1597/07-077.1
doi: 10.1597/07-077.1
pubmed: 19115788
Lopes LD, Mattos BS, Andre M (1991) Anomalies in number of teeth in patients with lip and/or palate clefts. Braz Dent J 2:9–17
pubmed: 1819360
Lopez-Gimenez A, Silvestre-Rangil J, Silvestre FJ, Paredes-Gallardo V (2018) Tooth agenesis code (TAC) in complete unilateral and bilateral cleft lip and palate patients. Odontology 106:257–265. https://doi.org/10.1007/s10266-017-0332-3
doi: 10.1007/s10266-017-0332-3
pubmed: 29243181
Menezes C, de Arruda JA, Silva LV, Monteiro JL, Caribe P, Alvares P et al (2018) Nonsyndromic cleft lip and/or palate: a multicenter study of the dental anomalies involved. J Clin Exp Dent 10:e746–e750. https://doi.org/10.4317/jced.54926
doi: 10.4317/jced.54926
pubmed: 30305871
pmcid: 6174020
Menezes LMd, Rizzatto SMD, Azeredo F, Vargas DA (2010) Characteristics and distribution of dental anomalies in a Brazilian cleft population. J Dent Sci 25:137–141. https://doi.org/10.1590/S1980-65232010000200006
doi: 10.1590/S1980-65232010000200006
Mikulewicz M, Oginski T, Gedrange T, Berniczei-Royko A, Prussak E (2014) Prevalence of second premolar hypodontia in the Polish cleft lip and palate population. Med Sci Monit 20:355–60. https://doi.org/10.12659/msm.890386
Nagai I, Fujiki Y, Fuchihata H, Yoshimoto T (1965) Supernumerary tooth associated with cleft lip and palate. J Am Dent Assoc 70:642–7. https://doi.org/10.14219/jada.archive.1965.0269
Oliveira DFB, Capelozza ALA, Carvalho IMMd (1996) Alteraçöes de desenvolvimento dentário em fissurados. Revista da Associacao Paulista de Cirurgiões Dentistas 50:83–86
Padricelli G, Monsurrò A, Grassia V, Perillo L (2012) The frequency of dental anomalies in subjects with cleft lip and palate. Mondo Ortod 37:46–55. https://doi.org/10.1016/j.mor.2011.11.001
doi: 10.1016/j.mor.2011.11.001
Paranaiba LM, Coletta RD, Swerts MS, Quintino RP, de Barros LM, Martelli-Junior H (2013) Prevalence of dental anomalies in patients with nonsyndromic cleft lip and/or palate in a Brazilian population. Cleft Palate Craniofac J 50:400–405. https://doi.org/10.1597/11-029
doi: 10.1597/11-029
pubmed: 21973329
Pegelow M, Alqadi N, Karsten AL (2012) The prevalence of various dental characteristics in the primary and mixed dentition in patients born with non-syndromic unilateral cleft lip with or without cleft palate. Eur J Orthod 34:561–570. https://doi.org/10.1093/ejo/cjr074
doi: 10.1093/ejo/cjr074
pubmed: 21750243
Polaczek T (1977) Occurrence of atypically shaped teeth in patients with cleft palate. Czas Stomatol 30:1075–1082
pubmed: 271542
Polaczek T (1978) Incidence of supernumerary teeth in patients with cleft of the primary and secondary palate. Czas Stomatol 31:665–672
pubmed: 278715
Raducanu AM, Didilescu AC, Feraru IV, Dumitrache MA, Hantoiu TA, Ionescu E (2015) Considerations on morphological abnormalities of permanent teeth in children with cleft lip and palate. Rom J Morphol Embryol 56:453–457
pubmed: 26193213
Ranta R, Stegars T, Rintala AE (1983) Correlations of hypodontia in children with isolated cleft palate. Cleft Palate J 20:163–165
pubmed: 6573982
Rengifo Reina HA (2016) Caracterización dental de niños colombianos con hendiduras labio palatinas no sindrómicas. Rev Odontol Mex 20:179–186
Ribeiro LL, Teixeira Das Neves L, Costa B, Ribeiro Gomide M (2003) Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate Craniofac J 40:172–175. https://doi.org/10.1597/1545-1569_2003_040_0172_daotpl_2.0.co_2
doi: 10.1597/1545-1569_2003_040_0172_daotpl_2.0.co_2
Sa J, Mariano LC, Cangucu D, Coutinho TS, Hoshi R, Medrado AP et al (2016) Dental anomalies in a Brazilian cleft population. Cleft Palate Craniofac J 53:714–719. https://doi.org/10.1597/14-303
doi: 10.1597/14-303
pubmed: 26575968
Saele P, Osthus E, Adalen S, Nasir EF, Mustafa M (2017) Pattern of clefts and dental anomalies in six-year-old children: a retrospective observational study in western Norway. Acta Odontol Scand 75:100–105. https://doi.org/10.1080/00016357.2016.1260770
doi: 10.1080/00016357.2016.1260770
pubmed: 27897086
Schroeder DC, Green LJ (1975) Frequency of dental trait anomalies in cleft, sibling, and noncleft groups. J Dent Res 54:802–807. https://doi.org/10.1177/00220345750540041801
doi: 10.1177/00220345750540041801
pubmed: 1057563
Schwartz JP, Somensi DS, Yoshizaki P, Reis LL, de Cassia Moura Carvalho Lauris R, de Silva Filho OG et al (2014) Prevalence of dental anomalies of number in different subphenotypes of isolated cleft palate. Dental Press J Orthod 19:55–9. https://doi.org/10.1590/2176-9451.19.1.055-059.oar
doi: 10.1590/2176-9451.19.1.055-059.oar
pubmed: 24713560
pmcid: 4299413
Shapira Y, Lubit E, Kuftinec MM (1999) Congenitally missing second premolars in cleft lip and cleft palate children. Am J Orthod Dentofacial Orthop 115:396–400. https://doi.org/10.1016/s0889-5406(99)70258-1
doi: 10.1016/s0889-5406(99)70258-1
pubmed: 10194283
Shapira Y, Lubit E, Kuftinec MM (2000) Hypodontia in children with various types of clefts. Angle Orthod 70:16–21. https://doi.org/10.1043/0003-3219(2000)070%3C0016:HICWVT%3E2.0.CO;2
doi: 10.1043/0003-3219(2000)070%3C0016:HICWVT%3E2.0.CO;2
pubmed: 10730671
Smolarska M (1973) Abnormalities concerning the number of upper permanent incisors in children with cleft palate. Czas Stomatol 26:519–522
pubmed: 4514799
Smolarska M (1976) Abnormalities in the number of upper deciduous incisors in children with a cleft palate. Czas Stomatol 29:1135–1141
pubmed: 1069627
Tan ELY, Kuek MC, Wong HC, Ong SAK, Yow M (2018) Secondary dentition characteristics in children with nonsyndromic unilateral cleft lip and palate: a retrospective study. Cleft Palate Craniofac J 55:582–589. https://doi.org/10.1177/1055665617750489
doi: 10.1177/1055665617750489
pubmed: 29554450
Tereza GP, Carrara CF, Costa B (2010) Tooth abnormalities of number and position in the permanent dentition of patients with complete bilateral cleft lip and palate. Cleft Palate Craniofac J 47:247–252. https://doi.org/10.1597/08-268.1
doi: 10.1597/08-268.1
pubmed: 20426674
Vicci JG, Razuk CG, Carvalho IMMd (2006) Ocorrência de anodontia do incisivo central superior em pessoas com fissura de lábio e/ou palato. Salusvita 25:51–60
Vichi M, Franchi L (1995) Abnormalities of the maxillary incisors in children with cleft lip and palate. ASDC J Dent Child 62:412–417
pubmed: 8636477
Vigueras Gómez O, Fernández Villavicencio MÁ, Villanueva Vilchis MdC (2015) Prevalencia de dientes supernumerarios en niños con labio y/o paladar fisurado. Rev Odontol Mex 19:81–88
Wu TT, Chen PK, Lo LJ, Cheng MC, Ko EW (2011) The characteristics and distribution of dental anomalies in patients with cleft. Chang Gung Med J 34:306–314
pubmed: 21733361
Kuzhalvaimozhi P, Ravindran V, Subhashini VC (2020) Developmental defects of enamel in children withand without cleft lip:a case control study. J Res Med Sci 8:298–302
Lasota A, Siebieszuk W, Pastuszak P and Mostowska A (2021) The prevalence and morphology of supernumerary teeth in children with nonsyndromic cleft lip and palate. Cleft Palate Craniofac J:10556656211027750. https://doi.org/10.1177/10556656211027750
Möller LH, Pradel W, Gedrange T, Botzenhart UU (2021) Prevalence of hypodontia and supernumerary teeth in a German cleft lip with/without palate population. BMC Oral Health 21:60. https://doi.org/10.1186/s12903-021-01420-7
doi: 10.1186/s12903-021-01420-7
pubmed: 33573652
pmcid: 7879655
Nzomiwu CL, Fomete B, Omisakin OO (2021) Dental anomalies associated with orofacial cleft among a group of individuals in Northwestern Nigeria. West Afr J Med 38:3–7
pubmed: 33463699
Pastuszak P, Dunin-Wilczyńska I, Lasota A (2020) Frequency of additional congenital dental anomalies in children with cleft lip, alveolar and palate. J Clin Med 9. https://doi.org/10.3390/jcm9123813
Pradhan L, Shakya P, Thapa S, Nakarmi KK, Maharjan A, Sagtani RA, et al (2020) Prevalence of dental anomalies in the patient with cleft lip and palate visiting a tertiary care hospital. J Nepal Med Assoc 58:591–596. https://doi.org/10.31729/jnma.5149
Yow M, Hermann NV, Wei Y, Karsten A, Kreiborg S (2020) Deep orofacial phenotyping of population-based infants with isolated cleft lip and isolated cleft palate. Sci Rep 10:21666. https://doi.org/10.1038/s41598-020-78602-w
doi: 10.1038/s41598-020-78602-w
pubmed: 33303814
pmcid: 7730196
Yow M, Hermann NV, Wei Y, Karsten A, Kreiborg S (2021) Dental subphenotypes in infants with orofacial clefts-a longitudinal population-based retrospective radiographic study of the primary and secondary dentitions. Cleft Palate Craniofac J:1055665621990148. https://doi.org/10.1177/1055665621990148
Abd Rahman N, Abdullah N, Samsudin AR, NaingMohdAyubSadiq L (2004) Dental anomalies and facial profile abnormality of the non-syndromic cleft lip and palate children in kelantan. Malays J Med Sci 11:41–51
pubmed: 22973126
pmcid: 3433975
Amaratunga NA (1987) An analysis of incidence of enamel hypoplasia in children with different types of cleft lip and palate. Odontostomatol Trop 10:107–110
pubmed: 3481849
Bezerra BT, Pinho JNA, Da Silva LCF (2017) Tooth abnormalities in individuals with unilateral alveolar clefts: a comparison between sides using cone-beam computed tomography. J Clin Exp Dent 9:e1195–e1200. https://doi.org/10.4317/jced.54043
doi: 10.4317/jced.54043
pubmed: 29167708
pmcid: 5694147
Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L (2010) Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent 20:442–450. https://doi.org/10.1111/j.1365-263X.2010.01063.x
doi: 10.1111/j.1365-263X.2010.01063.x
pubmed: 20642471
Costa CH, Diniz LV, Lacerda RH, Forte FD, Sampaio FC (2012) Prevalence of dental anomalies in patients with cleft lip and palate, Paraiba, Brazil: clinic and radiographic study. Acta Odontol Latinoam 25:181–185
pubmed: 23230639
Eerens K, Vlietinck R, Heidbuchel K, Van Olmen A, Derom C, Willems G et al (2001) Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls. Cleft Palate Craniofac J 38:374–378. https://doi.org/10.1597/1545-1569_2001_038_0374_hatfig_2.0.co_2
doi: 10.1597/1545-1569_2001_038_0374_hatfig_2.0.co_2
pubmed: 11420017
Galante JM, Costa B, de Carvalho Carrara CF, Gomide MR (2005) Prevalence of enamel hypoplasia in deciduous canines of patients with complete cleft lip and palate. Cleft Palate Craniofac J 42:675–678. https://doi.org/10.1597/04-068r.1
doi: 10.1597/04-068r.1
pubmed: 16241180
Gomes AC, Neves LT, Gomide MR (2009) Enamel defects in maxillary central incisors of infants with unilateral cleft lip. Cleft Palate Craniofac J 46:420–424. https://doi.org/10.1597/08-044.1
doi: 10.1597/08-044.1
pubmed: 19642773
Gutiérrez Guerra I, Valenzuela Rivera O (2014) Alteraciones de Número en Dentición de Pacientes entre 2 y 12 Años de Edad con Disrafias Labio Alvéolo Palatina Atendidos en la Unidad de Odontopediatría del Hospital Regional Antofagasta, Chile. Int j odontostomatol 8:481–490. https://doi.org/10.4067/S0718-381X2014000300025
doi: 10.4067/S0718-381X2014000300025
Hurtado AM, Rojas LM, Sanchez DM, García AM, Ortíz MA, Aguirre AF (2008) Prevalencia de caries y alteraciones dentales en niños con labio fisurado y paladar hendido de una fundación de Santiago de Cali. Revista Estomatología 16:13–17
Kamble S, Hiremath SS, Puranik MP, Gaikwad R, Biradar A, Gadbail AR et al (2017) Dental caries and dental anomalies in children with cleft lip and cleft palate in Bengaluru city, India. World J Dent 8:304–308. https://doi.org/10.5005/jp-journals-10015-1455
doi: 10.5005/jp-journals-10015-1455
Lacerda RHW, Machado da Costa CH, Vilar de Oliveira Diniz L, Soares Forte FD and Correia Sampaio F (2012) Prevalência de defeitos de esmalte em indivíduos portadores de fissuras labiopalatinas da Paraíba, Brasil. Rev Cuba Estomatol 49
Maciel SP, Costa B, Gomide MR (2005) Difference in the prevalence of enamel alterations affecting central incisors of children with complete unilateral cleft lip and palate. Cleft Palate Craniofac J 42:392–395. https://doi.org/10.1597/02-152.1
doi: 10.1597/02-152.1
pubmed: 16001921
Malanczuk T, Opitz C, Retzlaff R (1999) Structural changes of dental enamel in both dentitions of cleft lip and palate patients. J Orofac Orthop 60:259–268. https://doi.org/10.1007/bf01299784
doi: 10.1007/bf01299784
pubmed: 10450638
Ruiz LA, Maya RR, D’Alpino PH, Atta MT, da Rocha SN (2013) Prevalence of enamel defects in permanent teeth of patients with complete cleft lip and palate. Cleft Palate Craniofac J 50:394–399. https://doi.org/10.1597/11-200
doi: 10.1597/11-200
pubmed: 22292803
Sundell AL, Nilsson AK, Ullbro C, Twetman S, Marcusson A (2016) Caries prevalence and enamel defects in 5- and 10-year-old children with cleft lip and/or palate: a case-control study. Acta Odontol Scand 74:90–95. https://doi.org/10.3109/00016357.2015.1044562
doi: 10.3109/00016357.2015.1044562
pubmed: 25972142
Tamburini ABF, Rodrigues YHP, Martelli DRB, Barros LMd, Andrade RSd, Machado RA et al (2020) Anomalias dentárias na dentição decídua de pacientes com fissuras orais não sindrômicas. Rev Bras Saude Mater Infant 20:257–263. https://doi.org/10.1590/1806-93042020000100014
doi: 10.1590/1806-93042020000100014
Vanzin GD, Yamazaki K (2002) Prevalência de anomalias dentárias de número em pacientes portadores de fissura de lábio e palato. J Dent Sci 17:49–56
Matern O, Sauleau EA, Tschill P, Perrin-Schmitt F, Grollemund B (2012) Left-sided predominance of hypodontia irrespective of cleft sidedness in a French population. Cleft Palate Craniofac J 49:e1-5. https://doi.org/10.1597/11-025
doi: 10.1597/11-025
pubmed: 21905908
Cas NVd, Machado RA, Della Coletta R, Rangel ALCA (2020) Patterns of dental anomalies in patients with nonsyndromic oral cleft. Braz J Oral Sci 19:e208729–e208729
doi: 10.20396/bjos.v19i0.8658729
Huda NU, Shahzad HB, Noor M, Ishaq Y, Anwar MA, Kashif M (2021) Frequency of different dental irregularities associated with cleft lip and palate in a tertiary care dental hospital. Cureus 13:e14456. https://doi.org/10.7759/cureus.14456
doi: 10.7759/cureus.14456
pubmed: 33996316
pmcid: 8115193
Chopra A, Lakhanpal M, Rao NC, Gupta N, Vashisth S (2014) Oral health in 4–6 years children with cleft lip/palate: a case control study. N Am J Med Sci 6:266–269. https://doi.org/10.4103/1947-2714.134371
doi: 10.4103/1947-2714.134371
pubmed: 25006561
pmcid: 4083527
Kulas A, Illge C, Bekes K, Eckert AW, Fuhrmann RA, Hirsch C (2016) Structural color changes in permanent enamel of patients with cleft lip and palate: a case-control study. J Orofac Orthop 77:45–51. https://doi.org/10.1007/s00056-015-0007-z
doi: 10.1007/s00056-015-0007-z
pubmed: 26744208
World Health Organization (2001) Management of Noncommunicable Diseases. Global strategies to reduce the health-care burden of craniofacial anomalies: report of WHO meetings on International Collaborative Research on Craniofacial Anomalies. World Health Organization. https://apps.who.int/iris/handle/10665/42594 . Accessed 23 Jun 2021
Seo YJ, Park JW, Kim YH, Baek SH (2013) Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients. Angle Orthod 83:1036–1042. https://doi.org/10.2319/020513-104.1
doi: 10.2319/020513-104.1
pubmed: 23718693
pmcid: 8722836
Ghanim A, Elfrink M, Weerheijm K, Mariño R, Manton D (2015) A practical method for use in epidemiological studies on enamel hypomineralisation. Eur Arch Paediatr Dent 16:235–246. https://doi.org/10.1007/s40368-015-0178-8
doi: 10.1007/s40368-015-0178-8
pubmed: 25916282
pmcid: 4469791
Oliveira FV, Dionísio TJ, Neves LT, Machado MA, Santos CF, Oliveira TM (2014) Amelogenin gene influence on enamel defects of cleft lip and palate patients. Braz Oral Res 28:S1806-83242014000100240. https://doi.org/10.1590/1807-3107bor-2014.vol28.0035
doi: 10.1590/1807-3107bor-2014.vol28.0035
pubmed: 25229788
Lai PY, Seow WK (1989) A controlled study of the association of various dental anomalies with hypodontia of permanent teeth. Pediatr Dent 11:291–296
pubmed: 2639323
Stock NM, Humphries K, Pourcain BS, Bailey M, Persson M, Ho KM et al (2016) Opportunities and challenges in establishing a cohort study: an example from cleft lip/palate research in the United Kingdom. Cleft Palate Craniofac J 53:317–325. https://doi.org/10.1597/14-306
doi: 10.1597/14-306
pubmed: 26068383