The Pseudomonas aeruginosa DksA1 protein is involved in H
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 06 2022
21 06 2022
Historique:
received:
14
03
2022
accepted:
09
06
2022
entrez:
21
6
2022
pubmed:
22
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
In Gram-negative pathogens, the stringent response regulator DksA controls the expression of hundreds of genes, including virulence-related genes. Interestingly, Pseudomonas aeruginosa has two functional DksA paralogs: DksA1 is constitutively expressed and has a zinc-finger motif, while DksA2 is expressed only under zinc starvation conditions and does not contain zinc. DksA1 stimulates the production of virulence factors in vitro and is required for full pathogenicity in vivo. DksA2 can replace these DksA1 functions. Here, the role of dksA paralogs in P. aeruginosa tolerance to H
Identifiants
pubmed: 35729352
doi: 10.1038/s41598-022-14635-7
pii: 10.1038/s41598-022-14635-7
pmc: PMC9213440
doi:
Substances chimiques
Bacterial Proteins
0
Hydrogen Peroxide
BBX060AN9V
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10404Informations de copyright
© 2022. The Author(s).
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