Blood group antigens SLeX, SLeA, and LeY as prognostic markers in endometrial cancer.
Endometrial cancer
Lewis Y
Sialyl Lewis A
Sialyl Lewis X
Survival
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
07
02
2022
accepted:
27
05
2022
pubmed:
22
6
2022
medline:
26
10
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
Endometrial cancer (EC) is the most common gynecological cancer worldwide. Treatment has been improved in recent years, but, in advanced stages, therapeutical options are still limited. It has been reported that the expression of the blood group antigens Sialyl Lewis X (SLeX), Sialyl Lewis A (SLeA) and Lewis Y (LeY) is associated with prognosis in several tumors. Large studies on endometrial and cervical cancer are still pending. Specimens of 234 patients with EC were immunohistochemically stained with antibodies for SLeX, SLeA and LeY. Expression was correlated to histopathological variables. High expression of SLeX was correlated to low pT-stage (p = 0.013), low grade (p < 0.001), low FIGO-stage (p = 0.006) and better overall survival rates (OS; p = 0.023). High expression of SLeA was associated with low pT-stage (p = 0.013), low grade (p = 0.001) and better progression-free survival (PFS; p = 0.043). LeY staining was correlated to pN + (p = 0.038), low grade (p = 0.005) and poorer PFS (p = 0.022). This is the first study examining the expression of SLeX, SLeA and LeY in EC, which can serve as additional future prognostic markers. Further studies are necessary to understand the underlying mechanisms. The study was approved by the local ethics committee of the Ludwig-Maximilians University Munich (reference number 19-249).
Identifiants
pubmed: 35729354
doi: 10.1007/s00432-022-04098-8
pii: 10.1007/s00432-022-04098-8
pmc: PMC9587092
doi:
Substances chimiques
Sialyl Lewis X Antigen
0
CA-19-9 Antigen
0
Blood Group Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3323-3335Informations de copyright
© 2022. The Author(s).
Références
Am Fam Physician. 2016 Mar 15;93(6):468-74
pubmed: 26977831
Gynecol Obstet Invest. 1990;29(3):214-8
pubmed: 1972688
Int J Gynecol Cancer. 2003 Jan-Feb;13(1):42-6
pubmed: 12631219
Anticancer Res. 2005 May-Jun;25(3A):1615-22
pubmed: 16033070
Jpn J Cancer Res. 1991 Aug;82(8):934-41
pubmed: 1910029
Urol Oncol. 2015 Nov;33(11):496.e1-9
pubmed: 26137907
Kidney Int. 2005 Apr;67(4):1391-6
pubmed: 15780091
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13789-94
pubmed: 12370411
Science. 1990 Nov 23;250(4984):1130-2
pubmed: 1701274
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Nature. 2013 May 2;497(7447):67-73
pubmed: 23636398
Blood. 1999 Aug 1;94(3):884-94
pubmed: 10419878
Gynecol Oncol. 1983 Feb;15(1):10-7
pubmed: 6822361
Breast Cancer Res. 2005;7(5):R780-7
pubmed: 16168124
Hepatogastroenterology. 2003 May-Jun;50(51):756-60
pubmed: 12828079
Anticancer Res. 2002 Jan-Feb;22(1A):451-8
pubmed: 12017332
Glycoconj J. 2004;20(5):353-64
pubmed: 15229399
J Biol Chem. 2001 Nov 9;276(45):41527-42
pubmed: 11553646
Cancer Sci. 2005 Jan;96(1):26-30
pubmed: 15649251
Chang Gung Med J. 2007 May-Jun;30(3):189-209
pubmed: 17760270
Glycoconj J. 2020 Apr;37(2):277-291
pubmed: 32062824
Biochim Biophys Acta. 2014 Jan;1840(1):65-70
pubmed: 23999089
Histol Histopathol. 2012 Apr;27(4):507-14
pubmed: 22374728
J Exp Clin Cancer Res. 2009 Dec 15;28:154
pubmed: 20003467
Histol Histopathol. 2006 May;21(5):503-10
pubmed: 16493580
Neoplasma. 2009;56(1):40-7
pubmed: 19152244
Diagn Pathol. 2008 Sep 11;3:38
pubmed: 18786253
Biochimie. 2010 Jul;92(7):852-7
pubmed: 20172014
Cancer. 1987 Dec 15;60(12):2985-93
pubmed: 3677023
Future Oncol. 2017 Jan;13(2):145-157
pubmed: 27646625
Int J Gynecol Cancer. 2020 Feb;30(2):193-200
pubmed: 31792085
Ann Oncol. 2018 May 1;29(5):1180-1188
pubmed: 29432521
Biology (Basel). 2017 Feb 23;6(1):
pubmed: 28241499
Int J Gynecol Cancer. 2021 Jan;31(1):12-39
pubmed: 33397713
Carbohydr Res. 2015 Jan 30;402:124-32
pubmed: 25498012
Int J Oncol. 2018 Oct;53(4):1774-1786
pubmed: 30066907
Transfus Med Rev. 2009 Oct;23(4):292-309
pubmed: 19765518
Clin Mol Pathol. 1996 Jun;49(3):M126-35
pubmed: 16696060
Clin Cancer Res. 2020 Oct 1;26(19):5062-5067
pubmed: 32295834
Acta Biochim Pol. 2002;49(2):303-11
pubmed: 12362971
Int J Mol Med. 2019 Apr;43(4):1687-1698
pubmed: 30816446