Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy.

Cohort Studies Diabetes Mellitus, Type 1 / complications Diabetic Neuropathies / diagnosis Humans Pursuit, Smooth Saccades

Diabetic neuropathy Eye movement tracking Oculomotor system Type 1 diabetes

Journal

Acta diabetologica

ISSN: 1432-5233

Titre abrégé: Acta Diabetol

Pays: Germany

ID NLM: 9200299

Informations de publication

Date de publication:
Sep 2022

Historique:

received: 29 03 2022

accepted: 23 05 2022

pubmed: 22 6 2022

medline: 30 7 2022

entrez: 21 6 2022

Statut: ppublish

Résumé

Abnormalities in the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. We designed an eye-tracking-based test to evaluate oculomotor function in patients with type 1 diabetes. We used the SRLab-Tobii TX300 Eye tracker®, an eye-tracking device, coupled with software that we developed to test abnormalities in the oculomotor system. The software consists of a series of eye-tracking tasks divided into 4 classes of parameters (Resistance, Wideness, Pursuit and Velocity) to evaluate both smooth and saccadic movement in different directions. We analyzed the oculomotor system in 34 healthy volunteers and in 34 patients with long-standing type 1 diabetes. Among the 474 parameters analyzed with the eye-tracking-based system, 11% were significantly altered in patients with type 1 diabetes (p < 0.05), with a higher proportion of abnormalities observed in the Wideness (24%) and Resistance (10%) parameters. Patients with type 1 diabetes without diabetic neuropathy showed more frequently anomalous measurements in the Resistance class (p = 0.02). The classes of Velocity and Pursuit were less frequently altered in patients with type 1 diabetes as compared to healthy subjects, with anomalous measurements mainly observed in patients with diabetic neuropathy. Abnormalities in oculomotor system function can be detected in patients with type 1 diabetes using a novel eye-tracking-based test. A larger cohort study may further determine thresholds of normality and validate whether eye-tracking can be used to non-invasively characterize early signs of diabetic neuropathy. NCT04608890.

Identifiants

DOI: 10.1007/s00592-022-01911-1 PMID: 35729357 PMC: PMC9329167

pubmed: 35729357

doi: 10.1007/s00592-022-01911-1

pii: 10.1007/s00592-022-01911-1

pmc: PMC9329167

doi:

Banques de données

ClinicalTrials.gov

['NCT04608890']

Types de publication

Clinical Study Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1157-1167

Subventions

Organisme : European Foundation for the Study of Diabetes

ID : EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2019

Organisme : Ministero della Salute

ID : RF-2016-02362512

Informations de copyright

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