Evolution of gallium applications in medicine and microbiology: a timeline.
Antimicrobial activity
Gallium
Medicine
Microbiology
Semi-metal
Journal
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
ISSN: 1572-8773
Titre abrégé: Biometals
Pays: Netherlands
ID NLM: 9208478
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
13
01
2022
accepted:
26
05
2022
pubmed:
22
6
2022
medline:
28
7
2022
entrez:
21
6
2022
Statut:
ppublish
Résumé
Characterized as a semi-metal, gallium is a chemical element not found freely in the environment, but extracted as a by-product from other minerals. Despite of this, there are several gallium compounds with various applications, such as in the production of semiconductors, light emitting diodes; commercially as a potential cost reducer; pharmacology as cancer-related hypercalcemia, non-Hodgkin' lymphoma, breast and bladder cancer mainly and antimicrobial treatments. The latter will be emphasized in this work due to the contemporary emergence of the development of compounds with antimicrobial potential as a result of the spread of multidrug-resistant bacteria. So, this article discusses the main works, from the discovery of gallium to those that culminated in the current research in microbiology of the last two decades. The antimicrobial activity of gallium can be confirmed through the experimental data and be a promising mean to other investigations, especially due to its iron mimicry ability and the capacity to disrupt microorganisms' metabolism.
Identifiants
pubmed: 35729414
doi: 10.1007/s10534-022-00406-4
pii: 10.1007/s10534-022-00406-4
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents
0
Gallium
CH46OC8YV4
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
675-688Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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