Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections.
Anti-Bacterial Agents
/ pharmacology
Bacteria
Cefadroxil
/ therapeutic use
Cefazolin
/ pharmacology
Cephalexin
/ pharmacology
Cephalothin
/ therapeutic use
Child
Humans
Methicillin
/ therapeutic use
Microbial Sensitivity Tests
Oxacillin
/ therapeutic use
Staphylococcal Infections
/ drug therapy
Staphylococcus aureus
MIC
MSSA
cefadroxil
cephalexin
musculoskeletal infection
pediatric
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 08 2022
31 08 2022
Historique:
pubmed:
23
6
2022
medline:
9
9
2022
entrez:
22
6
2022
Statut:
ppublish
Résumé
Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Despite its shorter half-life, cephalexin is more frequently prescribed, although cefadroxil is an appealing alternative, given its slower clearance and possibility for less frequent dosing. We report comparative MIC distributions for cefadroxil and cephalexin, as well as for oxacillin, cephalothin, ceftaroline, and cefazolin, for 48 unique clinical MSSA isolates from pediatric patients with musculoskeletal infections. Both cefadroxil and cephalexin had MIC
Identifiants
pubmed: 35730963
doi: 10.1128/spectrum.01039-22
pmc: PMC9431593
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cefadroxil
280111G160
Cefazolin
IHS69L0Y4T
Cephalexin
OBN7UDS42Y
Methicillin
Q91FH1328A
Cephalothin
R72LW146E6
Oxacillin
UH95VD7V76
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0103922Subventions
Organisme : BLRD VA
ID : I01 BX002711
Pays : United States
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