Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder.
intrusive memory symptoms
minimal assumption spindle detection
post-traumatic stress disorder (PTSD)
sleep
sleep spindles
sleep-dependent memory consolidation
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
08 09 2022
08 09 2022
Historique:
received:
18
08
2021
revised:
04
05
2022
pubmed:
23
6
2022
medline:
11
9
2022
entrez:
22
6
2022
Statut:
ppublish
Résumé
Devastating and persisting traumatic memories are a central symptom of post-traumatic stress disorder (PTSD). Sleep problems are highly co-occurrent with PTSD and intertwined with its etiology. Notably, sleep hosts memory consolidation processes, supported by sleep spindles (11-16 Hz). Here we assess the hypothesis that intrusive memory symptoms in PTSD may arise from excessive memory consolidation, reflected in exaggerated spindling. We use a newly developed spindle detection method, entailing minimal assumptions regarding spindle phenotype, to assess spindle activity in PTSD patients and traumatized controls. Our results show increased spindle activity in PTSD, which positively correlates with daytime intrusive memory symptoms. Together, these findings provide a putative mechanism through which the profound sleep disturbance in PTSD may contribute to memory problems. Due to its uniform and unbiased approach, the new, minimal assumption spindle analysis seems a promising tool to detect aberrant spindling in psychiatric disorders.
Identifiants
pubmed: 35731633
pii: 6613204
doi: 10.1093/sleep/zsac139
pmc: PMC9453619
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society.
Références
Prog Brain Res. 2011;193:93-110
pubmed: 21854958
Nat Neurosci. 2015 Nov;18(11):1679-1686
pubmed: 26389842
J Neurosci. 2019 Jun 12;39(24):4775-4784
pubmed: 30988168
Neurosci Biobehav Rev. 2011 Apr;35(5):1154-65
pubmed: 21167865
Brain Res. 2011 Jan 7;1367:234-49
pubmed: 20888803
Physiol Behav. 2000 Jul 1-15;70(1-2):197-203
pubmed: 10978496
J Neurosci. 2013 Mar 6;33(10):4494-504
pubmed: 23467365
Science. 1993 Oct 29;262(5134):679-85
pubmed: 8235588
Sleep. 2020 Apr 15;43(4):
pubmed: 31702010
Sleep. 2015 Mar 01;38(3):423-31
pubmed: 25348121
Front Biosci. 2003 May 01;8:d878-99
pubmed: 12700074
Neuroreport. 2008 Jul 16;19(11):1159-62
pubmed: 18596620
Physiol Rev. 2020 Apr 1;100(2):805-868
pubmed: 31804897
Psychoneuroendocrinology. 2013 Jan;38(1):155-65
pubmed: 22776420
Arch Gen Psychiatry. 1995 Dec;52(12):1048-60
pubmed: 7492257
Nat Methods. 2014 Apr;11(4):385-92
pubmed: 24562424
J Trauma Stress. 2009 Aug;22(4):259-67
pubmed: 19645050
Eur J Psychotraumatol. 2019 Jul 22;10(1):1644128
pubmed: 31448066
Sci Rep. 2019 Feb 13;9(1):1940
pubmed: 30760741
Sleep. 2014 Apr 01;37(4):701-7, 707A
pubmed: 24688163
Biol Mood Anxiety Disord. 2015 May 29;5:3
pubmed: 26034578
Semin Clin Neuropsychiatry. 1999 Oct;4(4):242-8
pubmed: 10553029
J Trauma Stress. 2018 Oct;31(5):764-774
pubmed: 30338583
J Sleep Res. 2000 Dec;9(4):327-34
pubmed: 11386202
Learn Mem. 2012 Jun 14;19(7):264-7
pubmed: 22700468
J Neurosci. 2011 Jun 22;31(25):9124-34
pubmed: 21697364
Neuroimage. 2017 Feb 1;146:236-245
pubmed: 27840241
Am J Psychiatry. 2002 May;159(5):855-7
pubmed: 11986142
Brain Res. 2014 Dec 3;1591:63-73
pubmed: 25307136
Eur J Neurosci. 2015 May;41(9):1139-48
pubmed: 25720329
Clin Electroencephalogr. 1994 Jan;25(1):26-9
pubmed: 8174288
Sleep. 2010 Jan;33(1):69-74
pubmed: 20120622
Trends Cogn Sci. 2002 Nov 1;6(11):475-481
pubmed: 12457899
Neuroimage. 2014 Oct 1;99:103-10
pubmed: 24852461
Nat Commun. 2019 Aug 8;10(1):3572
pubmed: 31395890
Curr Biol. 2022 Jun 6;32(11):2349-2356.e4
pubmed: 35561681
Sleep. 2020 Jan 13;43(1):
pubmed: 31553047
Am J Psychiatry. 2013 Apr;170(4):372-82
pubmed: 23223954
Sleep. 2004 Dec 15;27(8):1479-85
pubmed: 15683137
Nature. 2005 Oct 27;437(7063):1272-8
pubmed: 16251952
J Anxiety Disord. 2010 Jan;24(1):1-15
pubmed: 19716676
PLoS One. 2011;6(11):e27421
pubmed: 22114672
J Sleep Res. 1997 Sep;6(3):149-55
pubmed: 9358392
Nat Commun. 2017 Jun 26;8:15930
pubmed: 28649997
J Neural Eng. 2021 Mar 03;18(2):
pubmed: 33326950
Psychoneuroendocrinology. 2018 Feb;88:136-143
pubmed: 29268182
J Neurosci. 2014 Dec 10;34(50):16890-901
pubmed: 25505340
Int J Psychophysiol. 2014 Aug;93(2):211-9
pubmed: 24793641
Exp Brain Res. 2014 May;232(5):1479-85
pubmed: 24531640
Sleep Med Rev. 2008 Jun;12(3):169-84
pubmed: 18424196
Eur J Neurosci. 2020 Jul;52(1):2429-2465
pubmed: 32125035
Eur J Psychotraumatol. 2020 Jul 09;11(1):1767349
pubmed: 33029311
J Cogn Neurosci. 2013 Oct;25(10):1597-610
pubmed: 23767926