T cell-neuron interaction in inflammatory and progressive multiple sclerosis biology.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
18
03
2022
revised:
18
05
2022
accepted:
18
05
2022
pubmed:
23
6
2022
medline:
26
7
2022
entrez:
22
6
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a chronic autoimmune condition of the central nervous system (CNS) characterized by acute inflammatory relapses, chronic neuro-axonal degeneration, and subsequent disability progression. T cells - in interaction with B cells and CNS-resident glial cells - are key initiators and drivers of neurodegeneration in MS. However, it is not entirely clear how encephalitogenic T cells orchestrate the local immune response within the brain and how they overtake disease stage-specific roles in MS pathogenesis. This review highlights recent advances in understanding direct and indirect T cell-neuron interactions in inflammatory and progressive MS. Finally, we discuss new diagnostic tools such as neurofilament light chain (NfL), which is on the cusp of becoming a key factor in clinical and therapeutic decision-making.
Identifiants
pubmed: 35732103
pii: S0959-4388(22)00082-4
doi: 10.1016/j.conb.2022.102588
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102588Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.