Use of graft materials and biologics in spine deformity surgery: a state-of-the-art review.
Deformity
Evidence
Osteobiologics
Outcomes
Review
Thorcaci spine
Journal
Spine deformity
ISSN: 2212-1358
Titre abrégé: Spine Deform
Pays: England
ID NLM: 101603979
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
06
08
2021
accepted:
21
05
2022
pubmed:
23
6
2022
medline:
21
10
2022
entrez:
22
6
2022
Statut:
ppublish
Résumé
The aim of the current review is to summarize the current evidence on graft materials used in fusion procedures for spinal deformity corrections. PubMed, Embase, and Cochrane Library were searched for relevant published observational studies and clinical trials using osteobiologics and biomaterials in spinal deformity surgery. The use of autograft in deformity correction surgeries has been reported in a limited number of studies, with the harvest sites including iliac crest, ribs, and local bone. Various allografts and biologics have been used in the treatment of spinal deformities including idiopathic and degenerative scoliosis, either as stand alone or in combination with autograft. Limited number of studies reported no differences in fusion rates or outcomes. Use of rh-BMP2 in anterior, posterior or front/back approaches showed higher fusion rates than other graft materials in patients with spinal deformities. Due to the limited number of quality studies included in the review, as well as alternative factors, such as costs, availability, and surgeon expertise/preference, no definitive conclusion or recommendations can be made as to the ideal graft choice in spinal deformity surgery. Most commonly used grafts included autograft, allograft and rh-BMP2, with new biologics and biomaterials constantly emerging in the market. Limited number of high-quality comparative studies and heterogeneity in study design prevented direct comparisons that can lead to meaningful recommendations. Further studies are needed to prove superiority of any single graft material and/or biologic that is also cost-effective and safe.
Identifiants
pubmed: 35733056
doi: 10.1007/s43390-022-00529-1
pii: 10.1007/s43390-022-00529-1
doi:
Substances chimiques
Biocompatible Materials
0
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1217-1231Informations de copyright
© 2022. The Author(s), under exclusive licence to Scoliosis Research Society.
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