Accurate Evaluation of Hepatocyte Metabolisms on a Noble Oxygen-Permeable Material With Low Sorption Characteristics.
4-polymethyl-1-pentene polymer
PDMS
chemical sorption
drug development
hepatocyte
oxygen supply
toxicity test
Journal
Frontiers in toxicology
ISSN: 2673-3080
Titre abrégé: Front Toxicol
Pays: Switzerland
ID NLM: 101777990
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
11
2021
accepted:
21
04
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
In the pharmaceutical industry, primary cultured hepatocytes is a standard tool used to assess hepatic metabolisms and toxicity
Identifiants
pubmed: 35733832
doi: 10.3389/ftox.2022.810478
pii: 810478
pmc: PMC9208656
doi:
Types de publication
Journal Article
Langues
eng
Pagination
810478Informations de copyright
Copyright © 2022 Nishikawa, Ito, Tokito, Hirono, Inamura, Scheidecker, Danoy, Kawanishi, Arakawa, Kato, Esashika, Miyasako and Sakai.
Déclaration de conflit d'intérêts
Authors KE and HM were employed by Mitsuichemicals, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Mitsuichemicals, Inc. The funder was involved in the study by way of authors from the company participating in the research.
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