Whole-Brain Monosynaptic Afferents to Rostromedial Tegmental Nucleus Gamma-Aminobutyric Acid-Releasing Neurons in Mice.
GABAergic neurons
monosynaptic inputs
mouse
rabies virus retrograde tracing
rostromedial tegmental area (RMTg)
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
04
2022
accepted:
16
05
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Increasing evidence has revealed that the rostromedial tegmental area (RMTg) mediates many behaviors, including sleep and addiction. However, presynaptic patterns governing the activity of γ-aminobutyric acid-releasing (GABAergic) neurons, the main neuronal type in the RMTg, have not been defined. Here, we used cell-type-specific retrograde trans-synaptic rabies viruses to map and quantify the monosynaptic afferents to RMTg GABAergic neurons in mouse whole brains. We identified 71 ascending projection brain regions. Sixty-eight percent of the input neurons arise from the ipsilateral and 32% from the contralateral areas of the brain. The first three strongest projection regions were the ipsilateral lateral hypothalamus, zone incerta, and contralateral pontine reticular nucleus. Immunohistochemistry imaging showed that the input neurons in the dorsal raphe, laterodorsal tegmentum, and dorsal part of zone incerta were colocalized with serotoninergic, cholinergic, and neuronal nitric oxide synthetase-expressing neurons, respectively. However, in the lateral hypothalamus, a few input neurons innervating RMTg GABAergic neurons colocalized orexinergic neurons but lacked colocalization of melanin-concentrating hormone neurons. Our findings provide anatomical evidence to understand how RMTg GABAergic neurons integrate diverse information to exert varied functions.
Identifiants
pubmed: 35733933
doi: 10.3389/fnins.2022.914300
pmc: PMC9207306
doi:
Types de publication
Journal Article
Langues
eng
Pagination
914300Informations de copyright
Copyright © 2022 Zhao, Zhang, Tao, Huang, Qu and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuropsychopharmacology. 2019 Oct;44(11):1896-1905
pubmed: 31060041
Histochem J. 1994 Nov;26(11):856-62
pubmed: 7868356
Proc Natl Acad Sci U S A. 2018 May 29;115(22):5792-5797
pubmed: 29752382
Behav Brain Res. 2019 Feb 1;359:950-957
pubmed: 29932954
Annu Rev Neurosci. 2019 Jul 8;42:27-46
pubmed: 30699051
Neuron. 2019 Dec 4;104(5):987-999.e4
pubmed: 31627985
Science. 2020 Jan 24;367(6476):440-445
pubmed: 31974254
Anesth Analg. 2021 Apr 1;132(4):e50-e55
pubmed: 33560660
Nat Neurosci. 2019 Jan;22(1):106-119
pubmed: 30559475
Exp Neurol. 2020 Nov;333:113433
pubmed: 32791155
Neuropsychopharmacology. 2018 Jul;43(8):1639-1650
pubmed: 29703994
Curr Opin Neurobiol. 2020 Feb;60:115-121
pubmed: 31864105
Neuron. 2019 Jun 5;102(5):944-959.e3
pubmed: 31030955
Development. 2016 Feb 1;143(3):516-29
pubmed: 26718003
J Neurosci. 2015 Apr 8;35(14):5435-41
pubmed: 25855162
Neuron. 2009 Mar 12;61(5):786-800
pubmed: 19285474
Neuroscience. 2005;130(1):1-15
pubmed: 15561420
Prog Brain Res. 2014;209:379-405
pubmed: 24746059
Annu Rev Neurosci. 2011;34:441-66
pubmed: 21469956
Nature. 2010 Jul 29;466(7306):622-6
pubmed: 20613723
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2180-8
pubmed: 27001837
Nat Neurosci. 2019 Apr;22(4):642-656
pubmed: 30858605
Trends Neurosci. 2015 Nov;38(11):672-673
pubmed: 26549881
J Comp Neurol. 2005 May 9;485(3):255-65
pubmed: 15791641
Front Integr Neurosci. 2015 May 27;9:39
pubmed: 26074791
Folia Morphol (Warsz). 2022;81(2):261-270
pubmed: 33634834
Neuropharmacology. 2019 Aug;154:34-49
pubmed: 30503993
Nature. 2015 Oct 15;526(7573):435-8
pubmed: 26444238
Eur J Neurosci. 2018 May;47(10):1208-1218
pubmed: 29480954
Neuron. 2020 Sep 9;107(5):954-971.e9
pubmed: 32589878
Front Physiol. 2018 Jun 25;9:788
pubmed: 29988603
PLoS Biol. 2018 Apr 13;16(4):e2002909
pubmed: 29652889
Anat Rec. 1997 Oct;249(2):259-75
pubmed: 9335473
Front Neural Circuits. 2021 Feb 25;15:639733
pubmed: 33732114
Dialogues Clin Neurosci. 2016 Mar;18(1):23-32
pubmed: 27069377
Nature. 2017 Aug 31;548(7669):582-587
pubmed: 28847002
Cell. 2017 Jul 13;170(2):382-392.e14
pubmed: 28689641
J Comp Neurol. 2001 Jul 16;436(1):52-63
pubmed: 11413546
Nat Neurosci. 2021 Nov;24(11):1601-1613
pubmed: 34663957
J Physiol Paris. 2006 Nov-Dec;100(5-6):271-83
pubmed: 17689057
Science. 2022 Feb 25;375(6583):eabh3021
pubmed: 35201886
Nat Neurosci. 2016 Oct;19(10):1356-66
pubmed: 27595385
Nature. 2021 Nov;599(7886):645-649
pubmed: 34732888
Neurosci Biobehav Rev. 2021 Dec;131:373-386
pubmed: 34562544
J Neurosci Methods. 1997 Jun 6;74(1):9-15
pubmed: 9210570
Neuropsychopharmacology. 2015 Feb;40(3):676-87
pubmed: 25164249
Nat Commun. 2018 Oct 25;9(1):4449
pubmed: 30361503
Nat Commun. 2018 Apr 20;9(1):1576
pubmed: 29679009
Transl Psychiatry. 2021 Feb 8;11(1):116
pubmed: 33558464
J Neurophysiol. 1985 Jan;53(1):292-308
pubmed: 2983038
Front Neural Circuits. 2013 Oct 11;7:152
pubmed: 24130517
Nature. 2018 Feb 14;554(7692):317-322
pubmed: 29446381
J Comp Neurol. 1985 Nov 22;241(4):480-92
pubmed: 4078044
Brain Struct Funct. 2019 Jan;224(1):219-238
pubmed: 30302539
Neuropsychopharmacology. 2008 Oct;33(11):2688-700
pubmed: 18094667
J Comp Neurol. 2009 Apr 20;513(6):566-96
pubmed: 19235216
J Comp Neurol. 2015 Jan 1;523(1):32-60
pubmed: 25099741
Behav Brain Res. 2008 Mar 17;188(1):84-90
pubmed: 18054396
Nature. 2018 Feb 8;554(7691):244-248
pubmed: 29420469
Neurosci Bull. 2022 May;38(5):548-552
pubmed: 35091996
J Comp Neurol. 1979 Sep 1;187(1):19-47
pubmed: 226566
Nat Commun. 2020 May 4;11(1):2195
pubmed: 32366867
Nat Sci Sleep. 2020 Dec 24;12:1215-1223
pubmed: 33380853
Alcohol Clin Exp Res. 2016 Aug;40(8):1651-61
pubmed: 27388762
Eur J Neurosci. 2005 May;21(9):2488-504
pubmed: 15932606
Front Integr Neurosci. 2011 Oct 03;5:49
pubmed: 22102836
Elife. 2019 Mar 11;8:
pubmed: 30855228
Front Neural Circuits. 2020 Jun 30;14:37
pubmed: 32694984
Eur J Neurosci. 2021 Jan;53(1):65-88
pubmed: 31833616
Cell. 2018 Oct 4;175(2):472-487.e20
pubmed: 30146164
Neuron. 2020 Sep 23;107(6):1029-1047
pubmed: 32755550
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):584-9
pubmed: 25548191
J Comp Neurol. 2014 May 1;522(7):1454-84
pubmed: 24374795
Nature. 2010 Nov 11;468(7321):263-9
pubmed: 21068835
Pain. 2019 Nov;160(11):2524-2534
pubmed: 31246732
Int J Physiol Pathophysiol Pharmacol. 2017 Dec 25;9(6):217-230
pubmed: 29348799
Am J Physiol. 1999 Feb;276(2):C395-403
pubmed: 9950767
Nat Commun. 2017 Sep 29;8(1):734
pubmed: 28963505
J Physiol. 2007 Nov 1;584(Pt 3):735-41
pubmed: 17884926
Neuron. 2017 Feb 22;93(4):747-765
pubmed: 28231463
J Neurosci. 2019 Oct 16;39(42):8225-8230
pubmed: 31619491
J Comp Neurol. 2017 Jul 1;525(10):2310-2327
pubmed: 28295296
Neuron. 2007 Mar 1;53(5):639-47
pubmed: 17329205
Front Neurosci. 2018 Nov 05;12:807
pubmed: 30455627
Sci Adv. 2015 Apr 03;1(3):e1400177
pubmed: 26601158
Neuropsychopharmacology. 2019 Jul;44(8):1464-1475
pubmed: 30928995
Neuron. 2021 Mar 17;109(6):918-937
pubmed: 33548173
Neuropharmacology. 2021 Oct 15;198:108763
pubmed: 34433088
Neuron. 2012 Nov 8;76(3):470-85
pubmed: 23141060