Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity.
Tryptases
eosinophil cationic protein
heat‐shock proteins
inflammation
nasal polyps
substance P
Journal
Laryngoscope investigative otolaryngology
ISSN: 2378-8038
Titre abrégé: Laryngoscope Investig Otolaryngol
Pays: United States
ID NLM: 101684963
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
23
11
2021
revised:
25
03
2022
accepted:
28
03
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Biomarker levels in nasal secretions can reflect the inflammatory status of nasal mucosa and evolution of sinus disease. The aim of this study was to evaluate the relationship between local inflammatory mediator production and clinical characteristics of patients with nasal polyposis (NP). Thirty-one nonaeroallergen sensitized patients with NP (NANP), 29 aeroallergen sensitized patients with NP (ANP), and 30 subjects without inflammation of nasal mucosa as controls (C) entered this prospective, cross-sectional study. Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed. The concentrations of heat shock protein 70 (HSP70), eosinophil cationic protein (ECP), tryptase, substance P and Clara cell protein 16 (CC16) were measured in the nasal secretion samples of all participants by ELISA method. Our results showed higher concentrations of HSP70, ECP, and tryptase in ANP than in NANP and C ( HSP70, ECP, tryptase, and substance P might play a role in the pathogenesis of NP. The results suggest that chronic inflammation in NP involves a self-sustaining local release of HSP70, ECP, and tryptase, independent of aeroallergen stimulation of the mucosal layer, although the production of these mediators is higher in aeroallergen sensitized NP patients.
Identifiants
pubmed: 35734071
doi: 10.1002/lio2.794
pii: LIO2794
pmc: PMC9194980
doi:
Types de publication
Journal Article
Langues
eng
Pagination
671-678Informations de copyright
© 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.
Déclaration de conflit d'intérêts
The authors declared no conflicts of interest.
Références
Rhinology. 1993 Dec;31(4):183-4
pubmed: 8140385
Arch Otolaryngol Head Neck Surg. 1997 Jun;123(6):595-600
pubmed: 9193219
Laryngoscope. 2002 Jan;112(1):53-8
pubmed: 11802038
Arh Hig Rada Toksikol. 2018 Sep 1;69(3):215-219
pubmed: 30285942
J Allergy Clin Immunol. 2004 Mar;113(3):462-9
pubmed: 15007348
Am J Rhinol Allergy. 2016 Jul;30(4):101-6
pubmed: 27456583
Eurasian J Med. 2017 Oct;49(3):178-182
pubmed: 29123440
ORL J Otorhinolaryngol Relat Spec. 1996 Jul-Aug;58(4):229-32
pubmed: 8883111
Inflammation. 2014 Dec;37(6):1912-8
pubmed: 24830325
Am J Rhinol. 1998 Jan-Feb;12(1):9-16
pubmed: 9513653
Otolaryngol Head Neck Surg. 2003 Sep;129(3 Suppl):S1-32
pubmed: 12958561
Clin Exp Allergy. 2009 Jan;39(1):12-9
pubmed: 19016800
Int Forum Allergy Rhinol. 2021 Mar;11(3):213-739
pubmed: 33236525
Rhinology. 2020 Feb 20;58(Suppl S29):1-464
pubmed: 32077450
Allergy Asthma Immunol Res. 2015 Jul;7(4):346-58
pubmed: 25936910
Cell Stress Chaperones. 2011 Nov;16(6):663-71
pubmed: 21643870
Int Forum Allergy Rhinol. 2016 May;6(5):529-36
pubmed: 26833624
Int Arch Allergy Immunol. 2001 Jun;125(2):164-75
pubmed: 11435734
Otolaryngol Head Neck Surg. 2015 Feb;152(1 Suppl):S1-43
pubmed: 25644617
B-ENT. 2012;8(1):25-32
pubmed: 22545387
Clin Exp Allergy. 2004 Jul;34(7):1086-92
pubmed: 15248854
Laryngoscope Investig Otolaryngol. 2019 Nov 13;4(6):573-577
pubmed: 31890873
Curr Opin Otolaryngol Head Neck Surg. 2008 Jun;16(3):226-30
pubmed: 18475076
Allergy Rhinol (Providence). 2016 Jan;7(1):14-20
pubmed: 27103555