LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda.
Bioefficacy
Durability
Insecticide
LLIN
Malaria
Piperonyl butoxide
Journal
Current research in parasitology & vector-borne diseases
ISSN: 2667-114X
Titre abrégé: Curr Res Parasitol Vector Borne Dis
Pays: Netherlands
ID NLM: 9918226380706676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
04
2022
revised:
06
05
2022
accepted:
18
05
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Long-lasting insecticidal nets (LLINs) supplemented with the synergist piperonyl butoxide have been developed in response to growing pyrethroid resistance; however, their durability in the field remains poorly described. A pragmatic cluster-randomised trial was embedded into Uganda's 2017-2018 LLIN distribution to compare the durability of LLINs with and without PBO. A total of 104 clusters (health sub-districts) were included with each receiving one of four LLIN products, two with pyrethroid + PBO (Olyset Plus and PermaNet 3.0) and two pyrethroid-only (Olyset Net and PermaNet 2.0). Nets were sampled at baseline, 12 and 25 months post-distribution to assess physical condition, chemical content, and bioefficacy. Physical condition was quantified using proportionate Hole Index and chemical content measured using high-performance liquid chromatography. Bioefficacy was assessed with three-minute World Health Organisation (WHO) Cone and Wireball assays using pyrethroid-resistant
Identifiants
pubmed: 35734077
doi: 10.1016/j.crpvbd.2022.100092
pii: S2667-114X(22)00018-8
pmc: PMC9207544
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100092Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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