Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms: Impact of expert centres.
expert centres
impact
management changes
multidisciplinary team
neuroendocrine neoplasms
Journal
European journal of cancer care
ISSN: 1365-2354
Titre abrégé: Eur J Cancer Care (Engl)
Pays: England
ID NLM: 9301979
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
10
01
2022
received:
05
11
2020
accepted:
06
06
2022
pubmed:
24
6
2022
medline:
30
11
2022
entrez:
23
6
2022
Statut:
ppublish
Résumé
To evaluate the impact of multidisciplinary team (MDT) meetings on the management of patients with neuroendocrine neoplasms (NENs). All newly referred gastro-entero-pancreatic (GEP)-NEN patients discussed from 1 April to 1 October 2017 in the MDT of seven European expert centres were prospectively included. The impact on patients' management was defined as a change in diagnosis, grade, stage or treatment. A total of 292 patients were included, mainly small intestinal (siNENs) (32%) and pancreatic NENs (28%), with distant metastases in 51%. Patients had received prior surgery in 43% of cases and prior medical treatment in 32%. A significant change occurred in 61% of NENs: 7% changes in diagnosis, 8% in grade and 16% in stage. The MDT recommended a new treatment for 51% of patients, mainly surgery (9%) or somatostatin analogues (20%). A significant change was most frequently observed in patients with Stage IV disease (hazard ratio [HR] 3.6, 95% confidence interval [CI]: 1.9-6.9 vs. Stage I) and G2 NENs (vs. G1, HR 2.1 95% CI: 1.2-3.8). NEN-dedicated MDT discussion in expert centres yields significant management changes in over 60% of patients and thus represents the gold standard for the management of these patients.
Types de publication
Journal Article
Langues
eng
Pagination
e13639Subventions
Organisme : Ipsen Scientific Exchange Program
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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