[Hyperkalemia due to low-molecular-weight heparin].
Hyperkaliëmie bij laag-molecuulgewicht heparine.
Journal
Nederlands tijdschrift voor geneeskunde
ISSN: 1876-8784
Titre abrégé: Ned Tijdschr Geneeskd
Pays: Netherlands
ID NLM: 0400770
Informations de publication
Date de publication:
20 06 2022
20 06 2022
Historique:
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
The cause of hyperkalemia is frequently iatrogenic. Patient's prescriptions should therefore be checked in the analysis of the hyperkalemia. Low-molecular-weight heparin is not often suspected to cause this. A 64-year-old man, hospitalized because of a complicated clinical course of pancreatitis, developed an acute severe hyperkalemia. Further analysis was susceptive for hypoaldosteronism, which was confirmed with biochemical testing. The only drug that could cause hyperkalemia in this case was nadroparin, which was prescribed because of vena lienalis and a superior mesenteric vein thrombosis. A rechallenge with nadroparin showed a rapid rise in serum potassium, confirming our suspicion. In the diagnostic work-up of hyperkalemia, hypoaldosteronism should be considered in patients using LMWH. In particular when other risk factors for hyperkalemia are present, monitoring of potassium could be advised in patients receiving these agents.
Sections du résumé
BACKGROUND
The cause of hyperkalemia is frequently iatrogenic. Patient's prescriptions should therefore be checked in the analysis of the hyperkalemia. Low-molecular-weight heparin is not often suspected to cause this.
CASE DESCRIPTION
A 64-year-old man, hospitalized because of a complicated clinical course of pancreatitis, developed an acute severe hyperkalemia. Further analysis was susceptive for hypoaldosteronism, which was confirmed with biochemical testing. The only drug that could cause hyperkalemia in this case was nadroparin, which was prescribed because of vena lienalis and a superior mesenteric vein thrombosis. A rechallenge with nadroparin showed a rapid rise in serum potassium, confirming our suspicion.
CONCLUSION
In the diagnostic work-up of hyperkalemia, hypoaldosteronism should be considered in patients using LMWH. In particular when other risk factors for hyperkalemia are present, monitoring of potassium could be advised in patients receiving these agents.
Substances chimiques
Anticoagulants
0
Heparin, Low-Molecular-Weight
0
Nadroparin
0
Heparin
9005-49-6
Potassium
RWP5GA015D
Types de publication
Case Reports
Journal Article
Langues
dut
Sous-ensembles de citation
IM