Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children.
amines
children
classical twin design
heritability
metabolites
organic acids
steroid hormones
urine
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
24 May 2022
24 May 2022
Historique:
received:
29
04
2022
revised:
18
05
2022
accepted:
20
05
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7-12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25-0.64), 0.50 (range: 0.33-0.62), and 0.64 (range: 0.43-0.81), respectively. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37-0.68), 0.50 (range; 0.23-0.61), and 0.47 (range: 0.32-0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones.
Identifiants
pubmed: 35736407
pii: metabo12060474
doi: 10.3390/metabo12060474
pmc: PMC9228478
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : EPA
ID : EP-C-15-001
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : European Union
ID : 602768
Références
Psychometrika. 2011 Apr 1;76(2):306-317
pubmed: 23258944
NPJ Digit Med. 2019 Nov 11;2:109
pubmed: 31728416
Twin Res Hum Genet. 2008 Feb;11(1):48-54
pubmed: 18251675
Am J Hum Genet. 2020 Nov 5;107(5):849-863
pubmed: 33031748
Twin Res Hum Genet. 2019 Dec;22(6):623-636
pubmed: 31666148
Twin Res Hum Genet. 2020 Jun;23(3):145-155
pubmed: 32635965
Plant Mol Biol. 2002 Jan;48(1-2):155-71
pubmed: 11860207
J Proteome Res. 2021 Aug 6;20(8):3992-4000
pubmed: 34304563
Twin Res. 2003 Oct;6(5):361-76
pubmed: 14624720
Twin Res. 2004 Oct;7(5):505-12
pubmed: 15527666
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4252-9
pubmed: 27036001
J Clin Endocrinol Metab. 2011 Sep;96(9):E1491-5
pubmed: 21752884
Nat Commun. 2020 Jan 7;11(1):39
pubmed: 31911595
Clin Pharmacol Ther. 2019 Sep;106(3):544-556
pubmed: 31173340
Behav Genet. 2019 Jan;49(1):99-111
pubmed: 30569348
Nat Genet. 2014 Jun;46(6):543-550
pubmed: 24816252
Clin Chem. 1994 Jun;40(6):862-6
pubmed: 8087979
Circ Cardiovasc Genet. 2014 Dec;7(6):854-863
pubmed: 25363705
J Lipid Res. 2020 Apr;61(4):537-545
pubmed: 32060071
Biometrics. 1990 Sep;46(3):673-87
pubmed: 2242409
J Clin Endocrinol Metab. 2020 Feb 1;105(2):
pubmed: 31608377
Psychoneuroendocrinology. 2018 Apr;90:76-84
pubmed: 29454168
Genetics. 2015 Jul;200(3):707-18
pubmed: 25977471
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):719-32
pubmed: 26913573
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):263-9
pubmed: 22436749
PLoS One. 2016 Apr 13;11(4):e0153672
pubmed: 27073872
Hum Mol Genet. 2021 Feb 4;29(23):3830-3844
pubmed: 33283231
Clin Endocrinol (Oxf). 2014 Feb;80(2):277-82
pubmed: 23746309
Twin Res Hum Genet. 2018 Jun;21(3):239-252
pubmed: 29743129
Nat Commun. 2019 Sep 24;10(1):4329
pubmed: 31551469
J Clin Endocrinol Metab. 2013 Mar;98(3):E518-27
pubmed: 23430788
Nat Rev Genet. 2002 Nov;3(11):872-82
pubmed: 12415317
Sci Rep. 2017 Nov 10;7(1):15351
pubmed: 29127340
Nucleic Acids Res. 2022 Jan 7;50(D1):D622-D631
pubmed: 34986597
Behav Genet. 1988 Jan;18(1):27-33
pubmed: 3365195
Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121
pubmed: 29845340
Front Endocrinol (Lausanne). 2020 Feb 20;11:59
pubmed: 32153504
Endocr Connect. 2020 Jun;9(6):542-551
pubmed: 32413849
Chem Soc Rev. 2011 Jan;40(1):387-426
pubmed: 20717559
Prostaglandins Leukot Essent Fatty Acids. 2021 Oct;173:102338
pubmed: 34500309
Aging (Albany NY). 2019 Feb 24;11(4):1262-1282
pubmed: 30799310
Sci Rep. 2017 Jun 16;7(1):3750
pubmed: 28623287
BMC Med. 2018 Nov 8;16(1):202
pubmed: 30404627
Nat Commun. 2016 Jul 25;7:12360
pubmed: 27453504
Am J Clin Nutr. 2021 May 8;113(5):1232-1240
pubmed: 33826700
Nat Genet. 2012 Jan 29;44(3):269-76
pubmed: 22286219
Psychophysiology. 1982 Jul;19(4):361-73
pubmed: 6889750
Front Psychiatry. 2020 Mar 31;11:165
pubmed: 32296350
J Clin Endocrinol Metab. 2011 Jun;96(6):E891-8
pubmed: 21450991
Elife. 2020 Jul 22;9:
pubmed: 32697195
Cell Metab. 2013 Jul 2;18(1):130-43
pubmed: 23823483
NMR Biomed. 2009 Oct;22(8):826-33
pubmed: 19441074
Ann Neurol. 1999 Mar;45(3):287-95
pubmed: 10072042
Brief Bioinform. 2002 Jun;3(2):119-33
pubmed: 12139432
Psychoneuroendocrinology. 1999 Jul;24(5):519-36
pubmed: 10378239
Genes Brain Behav. 2006 Jun;5(4):306-10
pubmed: 16716200
PLoS One. 2013 Sep 04;8(9):e73076
pubmed: 24023812