Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer's Disease with a Change in Metabolic Profile.
Alzheimer’s disease
MTHFD1
cerebrospinal fluid
folate
single nucleotide polymorphism
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
24 May 2022
24 May 2022
Historique:
received:
04
05
2022
revised:
20
05
2022
accepted:
20
05
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Metabolic disorders may be important potential causative pathways to Alzheimer's disease (AD). Cerebrospinal fluid (CSF) decreasing output, raised intracranial pressure, and ventricular enlargement have all been linked to AD. Cerebral folate metabolism may be a key player since this is significantly affected by such changes in CSF, and genetic susceptibilities may exist in this pathway. In the current study, we aimed to identify whether any single nucleotide polymorphism (SNPs) affecting folate and the associated metabolic pathways were significantly associated with AD. We took a functional nutrigenomics approach to look for SNPs in genes for the linked folate, methylation, and biogenic amine neurotransmitter pathways. Changes in metabolism were found with the SNPs identified. An abnormal SNP in methylene tetrahydrofolate dehydrogenase 1 (
Identifiants
pubmed: 35736408
pii: metabo12060475
doi: 10.3390/metabo12060475
pmc: PMC9230919
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Charles Wolfson Charitable Trust
ID : NA
Organisme : African Healthcare Development Trust
ID : NA
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