Colon Cancer: From Epidemiology to Prevention.
colorectal cancer
epidemiology
gut-on-chip
inter-individual diversity
intestinal microbiota
intra-individual variation
multi-omics
prevention
regenerative inflammation
risk factors
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
30 May 2022
30 May 2022
Historique:
received:
07
04
2022
revised:
23
05
2022
accepted:
24
05
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
24
6
2022
Statut:
epublish
Résumé
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a complex genetic and environmental aetiology. Unlike cancers with known environmental, heritable, or sex-linked causes, sporadic CRC is hard to foresee and has no molecular biomarkers of risk in clinical use. One in twenty CRC cases presents with an established heritable component. The remaining cases are sporadic and associated with partially obscure genetic, epigenetic, regenerative, microbiological, dietary, and lifestyle factors. To tackle this complexity, we should improve the practice of colonoscopy, which is recommended uniformly beyond a certain age, to include an assessment of biomarkers indicative of individual CRC risk. Ideally, such biomarkers will be causal to the disease and potentially modifiable upon dietary or therapeutic interventions. Multi-omics analysis, including transcriptional, epigenetic as well as metagenomic, and metabolomic profiles, are urgently required to provide data for risk analyses. The aim of this article is to provide a perspective on the multifactorial derailment of homeostasis leading to the initiation of CRC, which may be explored via multi-omics and Gut-on-Chip analysis to identify much-needed predictive biomarkers.
Identifiants
pubmed: 35736432
pii: metabo12060499
doi: 10.3390/metabo12060499
pmc: PMC9229931
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Research and Innovation Foundation
ID : EXCELLENCE/1216/0523
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