Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine.
Journal
Pharmacological reviews
ISSN: 1521-0081
Titre abrégé: Pharmacol Rev
Pays: United States
ID NLM: 0421737
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
28
6
2022
Statut:
ppublish
Résumé
A reliable translation of in vitro and preclinical data on drug absorption, distribution, metabolism, and excretion (ADME) to humans is important for safe and effective drug development. Precision medicine that is expected to provide the right clinical dose for the right patient at the right time requires a comprehensive understanding of population factors affecting drug disposition and response. Characterization of drug-metabolizing enzymes and transporters for the protein abundance and their interindividual as well as differential tissue and cross-species variabilities is important for translational ADME and precision medicine. This review first provides a brief overview of quantitative proteomics principles including liquid chromatography-tandem mass spectrometry tools, data acquisition approaches, proteomics sample preparation techniques, and quality controls for ensuring rigor and reproducibility in protein quantification data. Then, potential applications of quantitative proteomics in the translation of in vitro and preclinical data as well as prediction of interindividual variability are discussed in detail with tabulated examples. The applications of quantitative proteomics data in physiologically based pharmacokinetic modeling for ADME prediction are discussed with representative case examples. Finally, various considerations for reliable quantitative proteomics analysis for translational ADME and precision medicine and the future directions are discussed. SIGNIFICANCE STATEMENT: Quantitative proteomics analysis of drug-metabolizing enzymes and transporters in humans and preclinical species provides key physiological information that assists in the translation of in vitro and preclinical data to humans. This review provides the principles and applications of quantitative proteomics in characterizing in vitro, ex vivo, and preclinical models for translational research and interindividual variability prediction. Integration of these data into physiologically based pharmacokinetic modeling is proving to be critical for safe, effective, timely, and cost-effective drug development.
Identifiants
pubmed: 35738681
pii: 74/3/769
doi: 10.1124/pharmrev.121.000449
pmc: PMC9553121
doi:
Substances chimiques
Membrane Transport Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-796Subventions
Organisme : NICHD NIH HHS
ID : R01 HD081299
Pays : United States
Informations de copyright
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.
Références
J Pharm Sci. 2017 Dec;106(12):3453-3457
pubmed: 28778426
Mol Cell Proteomics. 2007 Dec;6(12):2139-49
pubmed: 17848587
mSystems. 2019 Aug 27;4(4):
pubmed: 31455640
Nat Methods. 2005 Sep;2(9):667-75
pubmed: 16118637
Expert Opin Drug Metab Toxicol. 2015;11(9):1357-69
pubmed: 26108733
Int J Mol Sci. 2015 Dec 02;16(12):28566-81
pubmed: 26633379
Xenobiotica. 2006 Dec;36(12):1191-200
pubmed: 17162466
Am J Hum Genet. 2008 Sep;83(3):337-46
pubmed: 18760392
Drug Metab Rev. 2009;41(2):89-295
pubmed: 19514967
Clin Pharmacol Ther. 2006 Jun;79(6):570-80
pubmed: 16765145
Clin Pharmacol Ther. 2019 Nov;106(5):1083-1092
pubmed: 31127606
Oncol Rep. 2017 Aug;38(2):1124-1132
pubmed: 28627631
Clin Pharmacol Ther. 2000 Jan;67(1):48-56
pubmed: 10668853
Drug Metab Dispos. 2012 Jan;40(1):83-92
pubmed: 21994437
Drug Metab Dispos. 2018 May;46(5):692-696
pubmed: 29439128
Drug Metab Pharmacokinet. 2015 Apr;30(2):205-8
pubmed: 25770030
J Proteome Res. 2019 Mar 1;18(3):803-813
pubmed: 30557026
Pharmacogenomics. 2008 Sep;9(9):1217-27
pubmed: 18781850
Anal Chem. 2009 Mar 15;81(6):2251-9
pubmed: 19209887
Drug Metab Dispos. 2015 Feb;43(2):284-8
pubmed: 25488931
J Pharm Sci. 2015 Sep;104(9):3039-48
pubmed: 25639366
Clin Pharmacol Ther. 2008 Jan;83(1):115-21
pubmed: 17522595
J Proteomics. 2014 Sep 23;109:322-31
pubmed: 25063446
Hepatol Commun. 2017 Jul 13;1(7):675-690
pubmed: 29404485
J Pharm Sci. 2013 Mar;102(3):787-93
pubmed: 23280364
BMB Rep. 2010 Aug;43(8):530-4
pubmed: 20797314
Drug Metab Dispos. 2001 Apr;29(4 Pt 2):570-3
pubmed: 11259354
J Pharmacol Exp Ther. 2001 Dec;299(3):825-31
pubmed: 11714865
Drug Metab Pharmacokinet. 2020 Feb;35(1):18-29
pubmed: 31952912
Mol Syst Biol. 2012;8:611
pubmed: 22968445
Drug Metab Dispos. 2021 Jan;49(1):39-52
pubmed: 33139459
Pharmacogenetics. 2004 Sep;14(9):615-26
pubmed: 15475735
Pharmacogenet Genomics. 2013 Jul;23(7):355-64
pubmed: 23652407
Br J Clin Pharmacol. 1983 Nov;16(5):503-9
pubmed: 6416284
Toxicol Lett. 2012 May 20;211(1):85-90
pubmed: 22429874
PLoS One. 2017 Dec 13;12(12):e0189521
pubmed: 29236753
J Gen Physiol. 1937 Sep 20;21(1):107-22
pubmed: 19873036
Drug Metab Dispos. 2012 May;40(5):852-5
pubmed: 22318656
Pharmacogenet Genomics. 2005 Sep;15(9):609-24
pubmed: 16041240
Circulation. 2010 Feb 2;121(4):512-8
pubmed: 20083681
Anal Chem. 2018 Oct 16;90(20):11873-11882
pubmed: 30204418
Drug Metab Dispos. 2016 Nov;44(11):1752-1758
pubmed: 27543206
Drug Metab Pharmacokinet. 2013;28(2):93-7
pubmed: 22850738
Indian J Med Res. 2006 May;123(5):665-70
pubmed: 16873909
J Pharmacol Exp Ther. 2014 Mar;348(3):465-77
pubmed: 24399855
Eur J Drug Metab Pharmacokinet. 2018 Aug;43(4):415-421
pubmed: 29392568
Drug Metab Dispos. 2012 Jan;40(1):93-103
pubmed: 21979928
J Pharmacol Exp Ther. 1999 Sep;290(3):1324-30
pubmed: 10454510
Hum Genomics. 2010 Apr;4(4):238-49
pubmed: 20511137
Clin Pharmacol Ther. 2019 Mar;105(3):719-729
pubmed: 30074626
Clin Pharmacokinet. 2014 Mar;53(3):283-293
pubmed: 24214317
Pharmacogenetics. 2003 Oct;13(10):619-26
pubmed: 14515060
Sci Rep. 2019 Apr 25;9(1):6571
pubmed: 31024054
Mol Cell Proteomics. 2014 Mar;13(3):907-17
pubmed: 24443746
Drug Metab Dispos. 2021 Aug;49(8):683-693
pubmed: 34074730
J Proteome Res. 2002 Jul-Aug;1(4):351-60
pubmed: 12645891
Pharmacogenetics. 2001 Jul;11(5):399-415
pubmed: 11470993
Clin Pharmacol Ther. 2021 Jan;109(1):222-232
pubmed: 33141922
Drug Metab Dispos. 2014 Jan;42(1):78-88
pubmed: 24122874
Clin Pharmacol Ther. 2017 Dec 22;:
pubmed: 29271075
Breast Cancer Res. 2011 Jun 09;13(3):R57
pubmed: 21658222
Pharmacogenet Genomics. 2018 Jan;28(1):7-16
pubmed: 29232328
Clin Pharmacol Ther. 2018 Apr;103(4):619-630
pubmed: 28833066
J Biol Eng. 2019 Nov 04;13:82
pubmed: 31709009
Mol Syst Biol. 2008;4:222
pubmed: 18854821
J Clin Pharmacol. 2020 Oct;60 Suppl 1:S17-S35
pubmed: 33205430
Drug Metab Dispos. 2019 Aug;47(8):802-808
pubmed: 31123036
Drug Metab Dispos. 2019 Apr;47(4):350-357
pubmed: 30622164
Biochem Soc Trans. 2020 Oct 30;48(5):1953-1966
pubmed: 33079175
Br J Clin Pharmacol. 2008 Apr;65(4):558-64
pubmed: 18070221
J Pharm Sci. 2019 Feb;108(2):1035-1046
pubmed: 30267783
J Proteome Res. 2018 Oct 5;17(10):3606-3612
pubmed: 30141943
Clin Pharmacol Ther. 2019 Jun;105(6):1407-1420
pubmed: 30554411
Pharmacogenetics. 2001 Jun;11(4):287-91
pubmed: 11434505
AAPS J. 2019 Jul 11;21(5):88
pubmed: 31297641
J Pharm Sci. 2017 Mar;106(3):738-744
pubmed: 27939376
J Proteome Res. 2017 Aug 4;16(8):2752-2761
pubmed: 28689405
Front Pharmacol. 2021 Apr 15;12:655320
pubmed: 33995076
Clin Pharmacol Ther. 2019 Jul;106(1):228-237
pubmed: 30673124
Methods Mol Biol. 2008;432:389-401
pubmed: 18370032
J Proteome Res. 2019 Jan 4;18(1):217-224
pubmed: 30336047
Liver Int. 2020 Jul;40(7):1770-1780
pubmed: 32243721
Onco Targets Ther. 2016 Mar 14;9:1461-9
pubmed: 27042114
Mol Pharm. 2013 Jan 7;10(1):289-96
pubmed: 23137377
AAPS J. 2017 Sep;19(5):1377-1386
pubmed: 28741221
Pediatr Res. 2018 Feb;83(2):527-535
pubmed: 28922349
Electrophoresis. 2003 Aug;24(16):2855-63
pubmed: 12929181
N Engl J Med. 1995 Nov 2;333(18):1171-5
pubmed: 7565971
Proteomics. 2007 Feb;7(3):340-50
pubmed: 17177251
Pharmacogenetics. 2004 Aug;14(8):539-47
pubmed: 15284536
Lancet. 1999 Feb 27;353(9154):717-9
pubmed: 10073515
Drug Metab Dispos. 2022 Mar;50(3):197-203
pubmed: 34969659
Oncotarget. 2017 Jun 28;8(37):62011-62028
pubmed: 28977922
Cancer Lett. 2005 Nov 8;229(1):25-31
pubmed: 16157215
Clin Drug Investig. 2013 Jan;33(1):11-23
pubmed: 23208320
J Biol Chem. 2003 Feb 28;278(9):7607-16
pubmed: 12493773
Drug Metab Dispos. 2022 Feb;50(2):105-113
pubmed: 34857529
Clin Res. 1991 Dec;39(4):615-23
pubmed: 1764889
Drug Metab Dispos. 2018 Apr;46(4):367-379
pubmed: 29343609
Methods Mol Biol. 2019;1916:3-39
pubmed: 30535679
Pharmacogenomics J. 2015 Dec;15(6):473-87
pubmed: 26526073
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5860-5
pubmed: 17389395
Mol Syst Biol. 2018 Aug 13;14(8):e8126
pubmed: 30104418
Clin Pharmacol Ther. 2019 Apr;105(4):899-911
pubmed: 30653670
Drug Metab Dispos. 2020 Jul;48(7):528-536
pubmed: 32350063
Drug Metab Dispos. 2021 Oct;49(10):919-928
pubmed: 34426410
Nat Methods. 2011 Jul 10;8(8):691-6
pubmed: 21743460
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6940-5
pubmed: 12771378
Nat Methods. 2005 Aug;2(8):587-9
pubmed: 16094383
Pharmacogenetics. 2003 Aug;13(8):461-72
pubmed: 12893984
Clin Cancer Res. 2015 May 15;21(10):2297-2304
pubmed: 25745036
Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):309-18
pubmed: 9089660
Nat Biotechnol. 2001 Oct;19(10):946-51
pubmed: 11581660
Drug Metab Dispos. 2018 Jun;46(6):888-896
pubmed: 29602798
Drug Metab Dispos. 2021 Mar;49(3):245-253
pubmed: 33355212
Clin Pharmacol Ther. 2020 May;107(5):1138-1148
pubmed: 31697849
Pharm Res. 2016 Sep;33(9):2280-8
pubmed: 27356525
J Neurochem. 2011 Apr;117(2):333-45
pubmed: 21291474
Nat Methods. 2019 Jun;16(6):519-525
pubmed: 31133761
Proteomics. 2011 Jan;11(1):33-41
pubmed: 21182192
Pharmacogenomics. 2016 Aug;17(13):1385-9
pubmed: 27469576
Pharmacogenomics J. 2010 Feb;10(1):1-11
pubmed: 19884908
J Pharmacol Exp Ther. 2017 Jan;360(1):129-139
pubmed: 27815364
Br J Anaesth. 1993 Aug;71(2):282-90
pubmed: 8123408
CPT Pharmacometrics Syst Pharmacol. 2018 Jul;7(7):464-473
pubmed: 29920988
J Clin Pharmacol. 2019 Jun;59(6):880-889
pubmed: 30690726
Drug Metab Dispos. 2018 Jul;46(7):943-952
pubmed: 29695616
J Steroid Biochem Mol Biol. 2019 Jul;191:105350
pubmed: 30959153
Curr Drug Metab. 2012 Jun 1;13(5):679-92
pubmed: 22299824
Proteomics. 2007 Dec;7(23):4292-302
pubmed: 17963278
J Chromatogr A. 2000 Feb 11;869(1-2):307-17
pubmed: 10720246
Drug Metab Dispos. 2020 Jan;48(1):31-40
pubmed: 31699809
Br J Clin Pharmacol. 2001 Oct;52(4):447-50
pubmed: 11678789
Clin Pharmacokinet. 2014 Jan;53(1):73-87
pubmed: 23881596
Br Med J (Clin Res Ed). 1983 Nov 12;287(6403):1424-7
pubmed: 6416440
Drug Metab Dispos. 2016 Jul;44(7):984-91
pubmed: 27084891
Eur J Pharm Sci. 2018 Nov 1;124:217-227
pubmed: 30171984
J Proteomics Bioinform. 2009 Jan 15;2(1):19-31
pubmed: 19436767
Drug Metab Dispos. 2013 Jun;41(6):1273-84
pubmed: 23554428
Eur J Clin Pharmacol. 2009 Apr;65(4):365-75
pubmed: 19031075
Meta Gene. 2014 Jan 20;2:134-42
pubmed: 25606397
Leuk Lymphoma. 2014 Mar;55(3):565-70
pubmed: 23829278
Mol Cell Proteomics. 2011 Dec;10(12):M111.007633
pubmed: 21931151
Ther Drug Monit. 2015 Apr;37(2):152-60
pubmed: 25090458
Diabetes. 1997 Jan;46(1):44-50
pubmed: 8971080
Nat Biotechnol. 1999 Oct;17(10):994-9
pubmed: 10504701
Vascul Pharmacol. 2007 Aug-Sep;47(2-3):83-9
pubmed: 17581795
Drug Metab Dispos. 2015 Mar;43(3):367-74
pubmed: 25534768
Arch Toxicol. 2021 Jan;95(1):117-133
pubmed: 33150952
Pharmacogenetics. 1998 Feb;8(1):15-26
pubmed: 9511177
Drug Metab Pharmacokinet. 2018 Apr;33(2):133-140
pubmed: 29610054
Pharmacogenomics. 2012 Sep;13(12):1373-85
pubmed: 22966887
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Drug Metab Dispos. 2015 Dec;43(12):1872-81
pubmed: 26374172
Hum Mutat. 2009 Sep;30(9):1310-9
pubmed: 19572376
Clin Pharmacol Ther. 1999 Aug;66(2):185-92
pubmed: 10460072
Mol Cell Proteomics. 2002 May;1(5):376-86
pubmed: 12118079
Pharm Res. 2008 Jun;25(6):1469-83
pubmed: 18219561
Mol Cell Proteomics. 2016 Feb;15(2):682-91
pubmed: 26631510
Clin Pharmacol Ther. 2020 Nov;108(5):976-984
pubmed: 32531808
Methods Protoc. 2019 Mar;2(1):
pubmed: 31008411
Curr Pharmacol Rep. 2020;6(3):71-84
pubmed: 32399388
CPT Pharmacometrics Syst Pharmacol. 2015 Jun;4(6):338-49
pubmed: 26225262
Drug Metab Dispos. 2010 Aug;38(8):1277-85
pubmed: 20421447
Front Genet. 2014 Apr 08;5:73
pubmed: 24782887
Drug Metab Dispos. 2020 Nov;48(11):1210-1216
pubmed: 32843330
BMC Med Genet. 2011 Jan 19;12:13
pubmed: 21247447
Pharmacogenetics. 2001 Mar;11(2):143-56
pubmed: 11266079
Clin Pharmacol Ther. 2008 Jun;83(6):898-903
pubmed: 18388866
J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8
pubmed: 22472908
Anal Bioanal Chem. 2016 May;408(13):3485-93
pubmed: 26942737
Food Chem Toxicol. 1997 Sep;35(9):903-7
pubmed: 9409631
Mol Pharm. 2011 Aug 1;8(4):1332-41
pubmed: 21707071
Drug Metab Dispos. 2017 Sep;45(9):1044-1048
pubmed: 28607029
Curr Drug Metab. 2008 Oct;9(8):738-84
pubmed: 18855611
Drug Metab Rev. 2009;41(3):408-21
pubmed: 19601720
Pharmacogenomics. 2013 Jul;14(10):1141-51
pubmed: 23859569
Drug Metab Dispos. 2015 Jun;43(6):836-42
pubmed: 25802327
Eur J Pharm Sci. 2021 Feb 1;157:105617
pubmed: 33164838
Br J Clin Pharmacol. 2019 Jan;85(1):216-226
pubmed: 30340248
Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3924-8
pubmed: 20335620
Drug Metab Dispos. 2017 Feb;45(2):216-223
pubmed: 27895113
Drug Metab Pharmacokinet. 2019 Feb;34(1):78-86
pubmed: 30528195
Nat Rev Drug Discov. 2002 Jan;1(1):37-44
pubmed: 12119608
Drug Metab Dispos. 2002 May;30(5):595-601
pubmed: 11950793
Sci Rep. 2019 Jul 4;9(1):9709
pubmed: 31273226
Clin Pharmacol Ther. 2012 Jul;92(1):96-102
pubmed: 22669291
Pharmacogenetics. 2000 Nov;10(8):679-85
pubmed: 11186130
Mol Cell Proteomics. 2012 Nov;11(11):1475-88
pubmed: 22865924
Clin Pharmacol Ther. 2021 Mar;109(3):762-771
pubmed: 32970864
CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):110-119
pubmed: 27935268
Clin Pharmacol Ther. 2004 Aug;76(2):128-38
pubmed: 15289790
Drug Metab Dispos. 2019 Jun;47(6):592-600
pubmed: 30885913
Anal Chim Acta. 2017 Apr 29;964:7-23
pubmed: 28351641
Br J Clin Pharmacol. 2003 Jan;55(1):68-76
pubmed: 12534642
Drug Metab Dispos. 2020 Sep;48(9):735-741
pubmed: 32591415
Pharmacogenomics J. 2016 Aug;16(4):375-87
pubmed: 26323597
Genet Med. 2018 Jun;20(6):622-629
pubmed: 29261188
Clin Pharmacol Ther. 2020 May;107(5):1128-1137
pubmed: 31630405
Clin Pharmacol Ther. 2016 Oct;100(4):362-70
pubmed: 27301780
J Pharmacol Exp Ther. 2003 Dec;307(3):906-22
pubmed: 14551287
J Pers Med. 2018 Apr 17;8(2):
pubmed: 29673183
Anal Chem. 2003 Apr 15;75(8):1895-904
pubmed: 12713048
Clin Pharmacol Ther. 2019 Jan;105(1):131-141
pubmed: 29737521
Clin Transl Sci. 2020 Jul;13(4):718-726
pubmed: 32004415
J Proteomics. 2015 Jan 15;113:388-99
pubmed: 25449833
J Pharm Sci. 2021 Jul;110(7):2833-2840
pubmed: 33785352
Expert Rev Proteomics. 2010 Feb;7(1):39-53
pubmed: 20121475
Clin Pharmacol Ther. 2018 Mar;103(3):485-492
pubmed: 28738449
Eur J Clin Pharmacol. 2002 Sep;58(6):417-21
pubmed: 12242601
Pharmacogenomics J. 2002;2(1):48-56
pubmed: 11990382
J Pharmacol Exp Ther. 2017 Mar;360(3):484-495
pubmed: 28057840
Mol Pharm. 2017 Mar 6;14(3):605-613
pubmed: 28112518
Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):327-31
pubmed: 12692107
Biochem Pharmacol. 2012 May 15;83(10):1427-34
pubmed: 22342776
J Clin Pharmacol. 2020 Oct;60 Suppl 1:S160-S178
pubmed: 33205429
Am J Hum Genet. 1997 Feb;60(2):284-95
pubmed: 9012401
JAMA. 2009 Aug 26;302(8):849-57
pubmed: 19706858
J Clin Pharmacol. 2003 Feb;43(2):133-40
pubmed: 12616665
J Pharm Sci. 2021 Jan;110(1):325-337
pubmed: 32946896
Drug Metab Dispos. 2011 Oct;39(10):1860-5
pubmed: 21746968
Pharmacogenomics. 2017 May;18(7):621-629
pubmed: 28470102
Toxicol Lett. 2019 Jan;300:40-50
pubmed: 30381255
Proteomics. 2011 Jun;11(12):2459-75
pubmed: 21595033
Biochem Biophys Res Commun. 2017 Sep 23;491(3):675-680
pubmed: 28756226
Mol Cell Proteomics. 2006 Nov;5(11):2131-45
pubmed: 16899541
J Clin Oncol. 2005 Dec 20;23(36):9312-8
pubmed: 16361630
Anal Chem. 1996 Jun 1;68(11):1918-23
pubmed: 8686914
Drug Metab Dispos. 2019 Aug;47(8):818-831
pubmed: 31101678
Drug Metab Dispos. 2021 Feb;49(2):159-168
pubmed: 33051248
Anal Chem. 2004 Apr 1;76(7):1817-23
pubmed: 15053638
J Pharmacol Exp Ther. 2017 Nov;363(2):265-274
pubmed: 28819071
Clin Pharmacol Ther. 2021 Jul;110(1):248-258
pubmed: 33792897