Impact of APOL1 kidney risk variants on glomerular transcriptomes.
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
29
12
2021
revised:
20
04
2022
accepted:
27
04
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
28
6
2022
Statut:
ppublish
Résumé
McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1 (the gene encoding apolipoprotein L1)-associated kidney disease, using bulk RNA sequencing. They found the following: APOL1 gene expression was higher in individuals with APOL1 high-risk genetic status; in glomeruli, STC1, encoding stanniocalcin, was the most upregulated gene, and CCL18, encoding C-C motif chemokine ligand 18, was the most downregulated gene; and nuclear factor kappa BNF-κB inhibitor-interacting Ras-like 1 (NKIRAS1) is the strongest hub gene. These findings identify disease pathways that might mediate or mitigate APOL1-associated nephropathies.
Identifiants
pubmed: 35738828
pii: S0085-2538(22)00365-9
doi: 10.1016/j.kint.2022.04.019
pii:
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Lipoproteins, HDL
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-19Commentaires et corrections
Type : CommentOn
Informations de copyright
Published by Elsevier Inc.