Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
17
12
2021
accepted:
06
05
2022
revised:
27
04
2022
pubmed:
24
6
2022
medline:
2
12
2022
entrez:
23
6
2022
Statut:
ppublish
Résumé
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
Identifiants
pubmed: 35739320
doi: 10.1038/s41380-022-01616-5
pii: 10.1038/s41380-022-01616-5
pmc: PMC9902274
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3731-3737Subventions
Organisme : NIMH NIH HHS
ID : R01 MH118695
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : Wellcome Trust
ID : 103703
Pays : United Kingdom
Organisme : CIHR
ID : 106469
Pays : Canada
Organisme : CIHR
ID : 142255
Pays : Canada
Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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