P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer's Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway.

Alzheimer Disease / pathology Amyloid beta-Peptides / metabolism Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism Forkhead Box Protein O3 / metabolism Forkhead Transcription Factors / metabolism Homeostasis Humans Mammals / metabolism Mitochondria / metabolism Passiflora / metabolism
Alzheimer’s disease DAF-16 DCT-1 Glutamatergic neurons Mitophagy

Journal

Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 28 12 2021
accepted: 26 05 2022
pubmed: 24 6 2022
medline: 25 8 2022
entrez: 23 6 2022
Statut: ppublish

Résumé

Alzheimer's disease (AD) is a common and devastating disease characterized by pathological aggregations of beta-amyloid (Aβ) plaques extracellularly, and Tau tangles intracellularly. While our understandings of the aetiologies of AD have greatly expanded over the decades, there is no drug available to stop disease progression. Here, we demonstrate the potential of Passiflora edulis (P. edulis) pericarp extract in protecting against Aβ-mediated neurotoxicity in mammalian cells and Caenorhabditis elegans (C. elegans) models of AD. We show P. edulis pericarp protects against memory deficit and neuronal loss, and promotes longevity in the Aβ model of AD via stimulation of mitophagy, a selective cellular clearance of damaged and dysfunctional mitochondria. P. edulis pericarp also restores memory and increases neuronal resilience in a C. elegans Tau model of AD. While defective mitophagy-induced accumulation of damaged mitochondria contributes to AD progression, P. edulis pericarp improves mitochondrial quality and homeostasis through BNIP3/DCT1-dependent mitophagy and SOD-3-dependent mitochondrial resilience, both via increased nuclear translocation of the upstream transcriptional regulator FOXO3/DAF-16. Further studies to identify active molecules in P. edulis pericarp that could maintain neuronal mitochondrial homeostasis may enable the development of potential drug candidates for AD.

Identifiants

DOI: 10.1007/s12035-022-02904-5 PMID: 35739408
pubmed: 35739408
doi: 10.1007/s12035-022-02904-5
pii: 10.1007/s12035-022-02904-5
doi:

Substances chimiques

Amyloid beta-Peptides 0
Caenorhabditis elegans Proteins 0
FOXO3 protein, human 0
Forkhead Box Protein O3 0
Forkhead Transcription Factors 0
daf-16 protein, C elegans 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5612-5629

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Shu-Qin Cao (SQ)

Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.

Yahyah Aman (Y)

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.

Evandro F Fang (EF)

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway. e.f.fang@medisin.uio.no.
The Norwegian Centre On Healthy Ageing (NO-Age), Oslo, Norway. e.f.fang@medisin.uio.no.

Tewin Tencomnao (T)

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. tewin.t@chula.ac.th.
Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok, 10330, Thailand. tewin.t@chula.ac.th.
ORCID: 0000-0003-4177-2165

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Protéine O3 à motif en tête de fourche › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › P. edulis Extract Protects Against Amyloid-β...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Passifloraceae › Passiflora › P. edulis Extract Protects Against Amyloid-β...