Anti-Oxidative Therapy in Islet Cell Transplantation.

antioxidants diabetes islet cell transplantation oxidative stress pancreatic β cell replacement therapy

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
24 May 2022
Historique:
received: 19 04 2022
revised: 16 05 2022
accepted: 18 05 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

Islet cell transplantation has become a favorable therapeutic approach in the treatment of Type 1 Diabetes due to the lower surgical risks and potential complications compared to conventional pancreas transplantation. Despite significant improvements in islet cell transplantation outcomes, several limitations hamper long-term graft survival due to tremendous damage and loss of islet cells during the islet cell transplantation process. Oxidative stress has been identified as an omnipresent stressor that negatively affects both the viability and function of isolated islets. Furthermore, it has been established that at baseline, pancreatic β cells exhibit reduced antioxidative capacity, rendering them even more susceptible to oxidative stress during metabolic stress. Thus, identifying antioxidants capable of conferring protection against oxidative stressors present throughout the islet transplantation process is a valuable approach to improving the overall outcomes of islet cell transplantation. In this review we discuss the potential application of antioxidative therapy during each step of islet cell transplantation.

Identifiants

pubmed: 35739935
pii: antiox11061038
doi: 10.3390/antiox11061038
pmc: PMC9219662
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Natsuki Eguchi (N)

Department of Surgery, University of California, Irvine, CA 92697, USA.

Kimia Damyar (K)

Department of Surgery, University of California, Irvine, CA 92697, USA.

Michael Alexander (M)

Department of Surgery, University of California, Irvine, CA 92697, USA.

Donald Dafoe (D)

Department of Surgery, University of California, Irvine, CA 92697, USA.

Jonathan R T Lakey (JRT)

Department of Surgery, University of California, Irvine, CA 92697, USA.
Department of Biomedical Engineering, University of California, Irvine, CA 92686, USA.

Hirohito Ichii (H)

Department of Surgery, University of California, Irvine, CA 92697, USA.

Classifications MeSH