Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications.
clinical trial
inflammation
inherited retinal dystrophies
oxidative stress
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 May 2022
30 May 2022
Historique:
received:
24
04
2022
revised:
24
05
2022
accepted:
26
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically heterogeneous diseases characterized by the progressive degeneration of the retina, ultimately leading to loss of visual function. Oxidative stress and inflammation play fundamental roles in the physiopathology of these diseases. Photoreceptor cell death induces an inflammatory state in the retina. The activation of several molecular pathways triggers different cellular responses to injury, including the activation of microglia to eliminate debris and recruit inflammatory cells from circulation. Therapeutical options for IRDs are currently limited, although a small number of patients have been successfully treated by gene therapy. Many other therapeutic strategies are being pursued to mitigate the deleterious effects of IRDs associated with oxidative metabolism and/or inflammation, including inhibiting reactive oxygen species' accumulation and inflammatory responses, and blocking autophagy. Several compounds are being tested in clinical trials, generating great expectations for their implementation. The present review discusses the main death mechanisms that occur in IRDs and the latest therapies that are under investigation.
Identifiants
pubmed: 35739983
pii: antiox11061086
doi: 10.3390/antiox11061086
pmc: PMC9219848
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : DGA and Fondo Europeo de Desarrollo Regional (FEDER) funds: "Una manera de hacer Europa".
ID : B08_17R
Organisme : Ministry of Science and Innovation cofinanced by European Regional Development Fund
ID : MICINN-FEDER PID2019-106230RB-I00
Organisme : Instituto de Salud Carlos III
ID : RETICS-FEDER-RD16/ 0008/0016
Organisme : Generalitat Valenciana
ID : PROME- TEO/2021/024, IDIFEDER/2017/064
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