The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.
calcium homeostasis
cancer
immune system
infectious disease
vitamin D
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 May 2022
30 May 2022
Historique:
received:
27
04
2022
revised:
27
05
2022
accepted:
28
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent. A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health. In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases. Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.
Sections du résumé
BACKGROUND
BACKGROUND
Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent.
METHODS
METHODS
A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health.
RESULTS
RESULTS
In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases.
CONCLUSIONS
CONCLUSIONS
Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.
Identifiants
pubmed: 35739987
pii: antiox11061090
doi: 10.3390/antiox11061090
pmc: PMC9220017
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
JAMA. 2005 May 11;293(18):2257-64
pubmed: 15886381
Hum Genet. 2010 Nov;128(5):549-56
pubmed: 20809279
Am J Hum Genet. 2020 Mar 5;106(3):327-337
pubmed: 32059762
J Steroid Biochem Mol Biol. 2018 Jan;175:12-17
pubmed: 28034764
Nat Rev Cancer. 2014 May;14(5):342-57
pubmed: 24705652
Cancer Causes Control. 2022 Feb;33(2):167-182
pubmed: 34708323
Steroids. 2012 Sep;77(11):1107-12
pubmed: 22801352
Clin Nutr. 2020 Sep;39(9):2663-2674
pubmed: 31959477
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):592-5
pubmed: 17267207
Neurology. 2012 Sep 25;79(13):1397-405
pubmed: 23008220
Clin Lab. 2019 Apr 1;65(4):
pubmed: 30969078
Int J Vitam Nutr Res. 2018 Feb;88(1-2):100-112
pubmed: 31038028
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):543-59
pubmed: 21872797
J Steroid Biochem Mol Biol. 2019 May;189:240-247
pubmed: 30654105
Nutrients. 2021 Jun 04;13(6):
pubmed: 34199802
Am J Clin Nutr. 2020 Sep 1;112(3):527-537
pubmed: 32542307
J Strength Cond Res. 2017 Feb;31(2):566-574
pubmed: 27379960
PLoS One. 2019 Apr 29;14(4):e0216284
pubmed: 31034511
Nutrients. 2022 Jan 27;14(3):
pubmed: 35276923
Diabetes Care. 2021 May;44(5):e106
pubmed: 33972323
Sci Rep. 2015 Oct 08;5:14875
pubmed: 26445902
Endocrinology. 2014 Sep;155(9):3227-37
pubmed: 24949660
BMC Cancer. 2019 May 23;19(1):488
pubmed: 31122213
J Biol Chem. 2016 Aug 19;291(34):17829-47
pubmed: 27402842
Mol Cell. 2000 Jan;5(1):173-9
pubmed: 10678179
J Nutr. 2021 Jan 4;151(1):98-103
pubmed: 33188401
Mol Cell Endocrinol. 2017 Sep 15;453:79-87
pubmed: 27913273
Eur J Cancer. 2011 Mar;47(5):732-41
pubmed: 21084183
Prog Biophys Mol Biol. 2006 Sep;92(1):33-8
pubmed: 16618499
J Bone Miner Res. 2010 Jul;25(7):1487-95
pubmed: 20200964
J Biol Chem. 2004 Apr 16;279(16):15897-907
pubmed: 14757768
FASEB J. 2012 Sep;26(9):3901-15
pubmed: 22683847
Pediatr Nephrol. 1996 Jun;10(3):364-7
pubmed: 8792407
BMJ Nutr Prev Health. 2021 Mar 16;4(1):352-353
pubmed: 34308145
JBMR Plus. 2020 Nov 04;5(1):e10420
pubmed: 33553987
Clin Nutr ESPEN. 2019 Apr;30:170-184
pubmed: 30904218
Trends Endocrinol Metab. 2003 Nov;14(9):423-30
pubmed: 14580762
Nat Commun. 2020 Nov 26;11(1):5997
pubmed: 33244003
Nutrition. 2021 Feb;82:111055
pubmed: 33288411
BJU Int. 2005 Sep;96(4):508-13
pubmed: 16104901
Cancers (Basel). 2021 Jun 22;13(13):
pubmed: 34206371
Crit Rev Eukaryot Gene Expr. 2009;19(3):171-80
pubmed: 19883363
Clin Cancer Res. 2005 May 1;11(9):3579-86
pubmed: 15867263
J Nutr. 2005 Feb;135(2):317-22
pubmed: 15671234
N Engl J Med. 1980 Aug 14;303(7):349-54
pubmed: 6248779
J Bone Miner Res. 2008 Nov;23(11):1789-97
pubmed: 18597628
J Clin Endocrinol Metab. 2013 Jul;98(7):2944-51
pubmed: 23609838
Lancet. 2004 Jan 24;363(9405):291-2
pubmed: 14751703
Laryngoscope Investig Otolaryngol. 2020 Nov 03;5(6):1079-1088
pubmed: 33364397
Clin Rheumatol. 2022 Jul;41(7):1979-1987
pubmed: 35253099
Medicine (Baltimore). 2013 May;92(3):123-131
pubmed: 23625163
PLoS One. 2015 Aug 31;10(8):e0136863
pubmed: 26322890
Front Endocrinol (Lausanne). 2018 Oct 09;9:600
pubmed: 30356853
J Clin Endocrinol Metab. 2015 Jul;100(7):E1005-13
pubmed: 25942481
Rev Endocr Metab Disord. 2022 Apr;23(2):279-285
pubmed: 35091881
J Am Heart Assoc. 2018 May 30;7(11):
pubmed: 29848497
J Immunol Res. 2022 Feb 10;2022:9025354
pubmed: 35242885
Eur J Nutr. 2016 Jun;55(4):1479-89
pubmed: 26130323
Am J Clin Nutr. 1982 Sep;36(3):426-30
pubmed: 6287835
Clin Nutr. 2019 Apr;38(2):829-834
pubmed: 29530546
JAMA. 2019 Aug 27;322(8):736-745
pubmed: 31454046
Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E753-60
pubmed: 15585593
J Bone Miner Res. 2012 Jan;27(1):187-94
pubmed: 21887707
Mol Endocrinol. 1997 Dec;11(13):1961-70
pubmed: 9415400
EPMA J. 2017 Nov 15;8(4):313-325
pubmed: 29209434
Endocr Rev. 2019 Aug 1;40(4):1109-1151
pubmed: 30321335
Nat Genet. 2016 Nov;48(11):1396-1406
pubmed: 27723756
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
J Assoc Physicians India. 2017 Nov;65(11):55-58
pubmed: 29322711
Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G341-9
pubmed: 26159695
Nutrients. 2022 Feb 28;14(5):
pubmed: 35268001
Biochim Biophys Acta. 2003 Jun 10;1632(1-3):40-7
pubmed: 12782149
J Steroid Biochem Mol Biol. 2020 Apr;198:105522
pubmed: 31733345
Nutrients. 2022 Jan 15;14(2):
pubmed: 35057541
J Steroid Biochem Mol Biol. 2017 Nov;174:314-321
pubmed: 27282116
JAMA Netw Open. 2019 Dec 2;2(12):e1917789
pubmed: 31860103
J Parkinsons Dis. 2013;3(4):547-55
pubmed: 24081441
Front Immunol. 2021 Jun 23;12:594356
pubmed: 34248925
Front Physiol. 2014 Sep 02;5:335
pubmed: 25228886
Nutrients. 2018 Jul 13;10(7):
pubmed: 30011816
Front Physiol. 2016 Nov 15;7:498
pubmed: 27895587
HIV Med. 2019 Feb;20(2):99-109
pubmed: 30461158
Mol Endocrinol. 1997 Sep;11(10):1518-31
pubmed: 9280067
J Clin Endocrinol Metab. 2018 Feb 1;103(2):564-574
pubmed: 29161417
Oncotarget. 2018 Apr 3;9(25):17915-17927
pubmed: 29707157
Biomedicines. 2022 Apr 14;10(4):
pubmed: 35453648
JAMA Netw Open. 2020 Nov 2;3(11):e2025850
pubmed: 33206192
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12920-5
pubmed: 9371776
Nutrients. 2020 Sep 10;12(9):
pubmed: 32927735
Endocrinol Metab (Seoul). 2021 Dec;36(6):1189-1200
pubmed: 34852423
J Dig Dis. 2018 Apr;19(4):225-234
pubmed: 29573237
Nutrients. 2020 Jul 15;12(7):
pubmed: 32679784
Endocr Relat Cancer. 2013 Jul 05;20(4):565-77
pubmed: 23744764
Int J Mol Sci. 2018 Sep 08;19(9):
pubmed: 30205552
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15650-5
pubmed: 24019477
Genet Test Mol Biomarkers. 2020 May;24(5):285-295
pubmed: 32255717
J Biol Chem. 2000 Nov 3;275(44):34650-5
pubmed: 10924511
J Clin Oncol. 2011 Nov 10;29(32):4337; author reply 4337-8
pubmed: 22010019
Exp Ther Med. 2022 Mar;23(3):240
pubmed: 35222717
Histochem Cell Biol. 2018 Apr;149(4):305-312
pubmed: 29435763
Int J Mol Sci. 2014 Jul 01;15(7):11678-99
pubmed: 24987952
Br Med J. 1973 Dec 22;4(5894):695-701
pubmed: 4776883
J Bone Miner Res. 2021 Sep;36(9):1651-1660
pubmed: 34405916
Endocrinol Metab Clin North Am. 2021 Dec;50(4):729-742
pubmed: 34774244
Curr HIV Res. 2011 Mar;9(2):70-81
pubmed: 21410431
Nutrition. 2016 May;32(5):515-23
pubmed: 26822497
J Interferon Cytokine Res. 2013 Nov;33(11):619-31
pubmed: 23962004
Oncol Rep. 2019 Mar;41(3):1476-1486
pubmed: 30569138
Steroids. 2001 Mar-May;66(3-5):441-50
pubmed: 11179753
Clinics (Sao Paulo). 2021 Nov 26;76:e3549
pubmed: 34852148
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):681-91
pubmed: 21872808
ISME J. 2016 Mar;10(3):742-50
pubmed: 26394008
Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):1003-16
pubmed: 21378269
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14754-9
pubmed: 14657394
Bone. 2020 Feb;131:115112
pubmed: 31676406
J Nutr Sci Vitaminol (Tokyo). 2022;68(1):16-22
pubmed: 35228491
Int J Cancer. 2011 Mar 15;128(6):1414-24
pubmed: 20473927
Bone. 2002 Apr;30(4):582-8
pubmed: 11934649
Clin Microbiol Rev. 2022 Jan 19;35(1):e0033820
pubmed: 34985325
Arch Biochem Biophys. 2021 Jul 15;705:108894
pubmed: 33965368
J Crohns Colitis. 2018 Jul 30;12(8):963-972
pubmed: 29726893
Clin Ther. 2015 May 1;37(5):996-1009.e7
pubmed: 26046242
HIV Med. 2016 Mar;17(3):196-205
pubmed: 26177791
Bosn J Basic Med Sci. 2006 Feb;6(1):24-8
pubmed: 16533175
Int J Obes (Lond). 2012 Sep;36(9):1252-5
pubmed: 22158264
J Nutr. 2013 Oct;143(10):1679-86
pubmed: 23966330
J Cancer Res Clin Oncol. 2008 Jun;134(6):653-8
pubmed: 17922290
J Clin Oncol. 2010 Sep 20;28(27):4191-8
pubmed: 20713849
Nutrients. 2017 May 08;9(5):
pubmed: 28481259
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Adv Exp Med Biol. 1986;196:361-75
pubmed: 3012979
Diabetes. 2011 May;60(5):1624-31
pubmed: 21441443
Am J Public Health. 2006 Feb;96(2):252-61
pubmed: 16380576
Prev Med. 2010 Sep-Oct;51(3-4):228-33
pubmed: 20600257
PLoS One. 2010 Mar 26;5(3):e9907
pubmed: 20360850
Lifestyle Genom. 2021;14(3):81-90
pubmed: 34139712
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5
pubmed: 15128933
Clin Microbiol Infect. 2012 Jul;18 Suppl 4:2-4
pubmed: 22647038
Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763
pubmed: 35325193
Endocrinology. 2000 Jul;141(7):2658-66
pubmed: 10875271
BMC Cancer. 2017 Aug 23;17(1):562
pubmed: 28835228
Ther Adv Musculoskelet Dis. 2016 Dec;8(6):225-235
pubmed: 28255336
Oncologist. 2012;17(1):36-45
pubmed: 22234628
J Steroid Biochem Mol Biol. 2015 Jul;151:25-37
pubmed: 25448732
JAMA Cardiol. 2017 Jun 1;2(6):608-616
pubmed: 28384800
Biol Trace Elem Res. 2022 Mar 10;:
pubmed: 35267138
Nature. 2007 Oct 18;449(7164):804-10
pubmed: 17943116
Mayo Clin Proc. 2013 Jul;88(7):720-55
pubmed: 23790560
Am J Clin Nutr. 2012 Jun;95(6):1357-64
pubmed: 22552031
Crit Rev Eukaryot Gene Expr. 2009;19(3):219-33
pubmed: 19883366
Oncotarget. 2017 Feb 7;8(6):9823-9834
pubmed: 28039464
Front Endocrinol (Lausanne). 2018 May 31;9:246
pubmed: 29904370
Cell Physiol Biochem. 2015;37(5):1686-92
pubmed: 26545152
Clin Invest Med. 2004 Feb;27(1):42-50
pubmed: 15061585
J Child Neurol. 2006 Mar;21(3):205-9
pubmed: 16901421
Front Immunol. 2021 Feb 23;12:627226
pubmed: 33732250
Compr Physiol. 2016 Mar 15;6(2):561-601
pubmed: 27065162
JAMA. 2019 Apr 9;321(14):1370-1379
pubmed: 30964527
J Biol Chem. 2010 Aug 13;285(33):25103-8
pubmed: 20501658
Maturitas. 2017 Sep;103:16-22
pubmed: 28778327
J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):372-6
pubmed: 23698025
J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:163-6
pubmed: 24333798
Exp Cell Res. 1998 May 25;241(1):194-201
pubmed: 9633528
J Biol Chem. 2003 Sep 26;278(39):38084-93
pubmed: 12867411
Endocrinol Metab Clin North Am. 2010 Jun;39(2):255-69, table of contents
pubmed: 20511050
Nutrients. 2020 Apr 27;12(5):
pubmed: 32349265
J Neurol. 2011 Sep;258(9):1676-82
pubmed: 21431378
BMJ Open. 2019 Nov 12;9(11):e031083
pubmed: 31722941
Adv Exp Med Biol. 2014;810:500-25
pubmed: 25207384
Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226
pubmed: 11693961
Hum Mol Genet. 2010 Jul 1;19(13):2739-45
pubmed: 20418485
J Steroid Biochem Mol Biol. 2022 Jun;220:106083
pubmed: 35257869
J Steroid Biochem Mol Biol. 2022 May;219:106084
pubmed: 35202799
Mol Pharmacol. 2012 Apr;81(4):498-509
pubmed: 22205755
Nutrients. 2015 Jun 25;7(7):5111-42
pubmed: 26121531
Front Endocrinol (Lausanne). 2020 Jan 10;10:910
pubmed: 31998239
Biochem Biophys Res Commun. 2001 Nov 2;288(3):690-6
pubmed: 11676498
Front Immunol. 2020 Jan 21;10:3141
pubmed: 32038645
Toxicology. 2017 Apr 15;381:31-38
pubmed: 28237619
Eur Rev Med Pharmacol Sci. 2017 Jan;21(1):1-3
pubmed: 28121364
Endocrinology. 2011 Aug;152(8):2976-86
pubmed: 21673099
Contemp Clin Trials. 2012 Jan;33(1):159-71
pubmed: 21986389
Curr Trop Med Rep. 2021;8(3):204-211
pubmed: 33816060
Metabolites. 2021 Apr 20;11(4):
pubmed: 33924215
Am J Clin Nutr. 2006 Oct;84(4):694-7
pubmed: 17023693
Cells. 2021 Nov 07;10(11):
pubmed: 34831289
Metabolism. 2019 Mar;92:193-205
pubmed: 30615949
Cancer. 2006 Jul 15;107(2):266-74
pubmed: 16779800
J Steroid Biochem Mol Biol. 2017 Oct;173:317-322
pubmed: 28323044
Exp Gerontol. 2022 May;161:111709
pubmed: 35090975
Front Horm Res. 2018;50:1-13
pubmed: 29597231
Int J Mol Sci. 2020 Sep 04;21(18):
pubmed: 32899880
Cancer Prev Res (Phila). 2011 May;4(5):735-43
pubmed: 21430073
J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:28-39
pubmed: 24176765
Br J Nutr. 2013 Mar 28;109(6):1082-8
pubmed: 23168298
Curr HIV Res. 2010 Apr;8(3):218-22
pubmed: 20158458
Curr Vasc Pharmacol. 2021;19(3):250-268
pubmed: 32183681
BMJ. 2017 Feb 15;356:i6583
pubmed: 28202713
Oncologist. 2011;16(9):1215-27
pubmed: 21835895
J Korean Med Sci. 2020 Mar 02;35(8):e50
pubmed: 32103645
Scand J Immunol. 2022 May;95(5):e13146
pubmed: 35073416
Nutrients. 2017 Jun 24;9(7):
pubmed: 28672793
Med Sci (Basel). 2021 Jan 30;9(1):
pubmed: 33573146
Lancet. 2010 Jul 17;376(9736):180-8
pubmed: 20541252
Biochem Biophys Res Commun. 1977 May 9;76(1):107-14
pubmed: 194588
Ann Saudi Med. 2011 Nov-Dec;31(6):602-8
pubmed: 22048506
J Bone Miner Res. 2017 Sep;32(9):1893-1899
pubmed: 28548312
Front Biosci (Elite Ed). 2012 Jun 01;4(7):2442-56
pubmed: 22652651
Hum Mol Genet. 2005 Nov 15;14(22):3539-48
pubmed: 16210379
J Clin Endocrinol Metab. 2013 Mar;98(3):973-9
pubmed: 23386645
Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4664-4669
pubmed: 27906437
Cancer. 2006 May 15;106(10):2136-42
pubmed: 16598750
N Engl J Med. 2019 Jan 3;380(1):33-44
pubmed: 30415629
Oncoimmunology. 2018 Jul 23;7(9):e1476817
pubmed: 30228945
Med Hypotheses. 2016 Sep;94:103-7
pubmed: 27515213
Mol Endocrinol. 2010 Jan;24(1):128-47
pubmed: 19897601
Clin Exp Immunol. 2019 Jun;196(3):336-344
pubmed: 30737776
J Bone Miner Res. 2001 Jul;16(7):1256-64
pubmed: 11450701
Mol Endocrinol. 2000 Mar;14(3):401-20
pubmed: 10707958