EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases.
RNA modification
methylation
miRNA variants
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
30 May 2022
30 May 2022
Historique:
received:
27
04
2022
revised:
24
05
2022
accepted:
26
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
MicroRNAs (miRNAs) are synthesized through a canonical pathway and play a role in human diseases, such as cancers and cardiovascular, neurodegenerative, psychiatric, and chronic inflammatory diseases. The development of sequencing technologies has enabled the identification of variations in noncoding miRNAs. These miRNA variants, called isomiRs, are generated through a non-canonical pathway, by several enzymes that alter the length and sequence of miRNAs. The isomiR family is, now, expanding further to include episomiRs, which are miRNAs with different modifications. Since recent findings have shown that isomiRs reflect the cell-specific biological function of miRNAs, knowledge about episomiRs and isomiRs can, possibly, contribute to the optimization of diagnosis and therapeutic technology for precision medicine.
Identifiants
pubmed: 35740302
pii: biomedicines10061280
doi: 10.3390/biomedicines10061280
pmc: PMC9220071
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 20H00541; 21K19526
Organisme : Princess Takamatsu Cancer Research Fund, Senshin Medical Research Foundation, and Mitsubishi Foundation
ID : 2021 grant
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