Dietary Improvement during Lactation Normalizes miR-26a, miR-222 and miR-484 Levels in the Mammary Gland, but Not in Milk, of Diet-Induced Obese Rats.
lactation
mammary gland
miRNA
obesogenic diet
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
31 May 2022
31 May 2022
Historique:
received:
08
05
2022
revised:
24
05
2022
accepted:
24
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
We aimed to evaluate in rats whether the levels of specific miRNA are altered in the mammary gland (MG) and milk of diet-induced obese dams, and whether improving maternal nutrition during lactation attenuates such alterations. Dams fed with a standard diet (SD) (control group), with a Western diet (WD) prior to and during gestation and lactation (WD group), or with WD prior to and during gestation but moved to SD during lactation (Rev group) were followed. The WD group showed higher miR-26a, miR-222 and miR-484 levels than the controls in the MG, but the miRNA profile in Rev animals was not different from those of the controls. The WD group also displayed higher miR-125a levels than the Rev group. Dams of the WD group, but not the Rev group, displayed lower mRNA expression levels of
Identifiants
pubmed: 35740314
pii: biomedicines10061292
doi: 10.3390/biomedicines10061292
pmc: PMC9219892
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FEDER Una manera de hacer Europa
ID : Proyecto PGC2018-097436-B-I00 financiado por MCIN/ AEI/10.13039/501100011033
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