Future Treatment of Neuropathic Pain in Spinal Cord Injury: The Challenges of Nanomedicine, Supplements or Opportunities?
nanomedicine
nanotechnology
neuropathic pain
pain
spinal cord injury
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
10 Jun 2022
10 Jun 2022
Historique:
received:
18
04
2022
revised:
28
05
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Neuropathic pain (NP) is a common chronic condition that severely affects patients with spinal cord injuries (SCI). It impairs the overall quality of life and is considered difficult to treat. Currently, clinical management of NP is often limited to drug therapy, primarily with opioid analgesics that have limited therapeutic efficacy. The persistence and intractability of NP following SCI and the potential health risks associated with opioids necessitate improved treatment approaches. Nanomedicine has gained increasing attention in recent years for its potential to improve therapeutic efficacy while minimizing toxicity by providing sensitive and targeted treatments that overcome the limitations of conventional pain medications. The current perspective begins with a brief discussion of the pathophysiological mechanisms underlying NP and the current pain treatment for SCI. We discuss the most frequently used nanomaterials in pain diagnosis and treatment as well as recent and ongoing efforts to effectively treat pain by proactively mediating pain signals following SCI. Although nanomedicine is a rapidly growing field, its application to NP in SCI is still limited. Therefore, additional work is required to improve the current treatment of NP following SCI.
Identifiants
pubmed: 35740395
pii: biomedicines10061373
doi: 10.3390/biomedicines10061373
pmc: PMC9219608
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : RF-2018-12365682
Références
Front Hum Neurosci. 2016 Oct 27;10:544
pubmed: 27833544
AAPS PharmSciTech. 2015 Apr;16(2):413-27
pubmed: 25354788
Sci Adv. 2019 Feb 13;5(2):eaau5148
pubmed: 30788432
Exp Neurol. 2012 Apr;234(2):362-72
pubmed: 22036747
Mayo Clin Proc. 2015 Aug;90(8):1135-51
pubmed: 26250730
Anesthesiology. 1999 May;90(5):1402-12
pubmed: 10319789
Neuropharmacology. 2011 Apr;60(5):799-808
pubmed: 21216257
J Pharmacol Sci. 2013;123(2):203-6
pubmed: 24096830
Pain. 1999 Dec;83(3):389-400
pubmed: 10568846
J Neurosci. 2012 Oct 24;32(43):14874-84
pubmed: 23100410
Pharm Res. 2016 Oct;33(10):2373-87
pubmed: 27299311
Crit Rev Phys Rehabil Med. 2013;25(3-4):159-172
pubmed: 25750485
J Pain. 2009 Sep;10(9):895-926
pubmed: 19712899
Pain. 1997 Sep;72(3):295-8
pubmed: 9313269
Curr Opin Pharmacol. 2001 Feb;1(1):66-72
pubmed: 11712538
Pharm Res. 1997 Mar;14(3):325-8
pubmed: 9098875
Front Neurol. 2022 Mar 21;13:818522
pubmed: 35386408
Lancet. 1999 Jun 5;353(9168):1959-64
pubmed: 10371588
J Neurosci. 2012 Feb 22;32(8):2601-7
pubmed: 22357844
Phys Life Rev. 2016 Mar;16:191-4
pubmed: 26917254
Pain Med. 2020 Nov 1;21(11):2913-2924
pubmed: 32219441
Nanomedicine (Lond). 2011 Jul;6(5):815-35
pubmed: 21793674
Tissue Eng Part B Rev. 2021 Aug;27(4):353-365
pubmed: 33135599
Physiol Rev. 2021 Jan 1;101(1):259-301
pubmed: 32584191
JAMA. 2003 Oct 1;290(13):1757-62
pubmed: 14519710
Eur J Pain. 2013 Jan;17(1):55-66
pubmed: 22610590
Curr Opin Pharmacol. 2002 Feb;2(1):50-5
pubmed: 11786308
Pain. 2013 Dec;154 Suppl 1:S71-S76
pubmed: 23375163
Am J Phys Med Rehabil. 1996 Mar-Apr;75(2):84-7
pubmed: 8630199
Nat Biotechnol. 2015 Sep;33(9):941-51
pubmed: 26348965
Anticancer Agents Med Chem. 2017;17(8):1033-1039
pubmed: 28042778
Front Physiol. 2020 Jul 07;11:748
pubmed: 32733271
J Nanosci Nanotechnol. 2018 Jun 1;18(6):4428-4438
pubmed: 29442800
Spinal Cord. 2012 Jun;50(6):413-7
pubmed: 22182852
Neurosurgery. 2013 Mar;72 Suppl 2:93-105
pubmed: 23417182
AJNR Am J Neuroradiol. 2002 Jun-Jul;23(6):901-5
pubmed: 12063213
Brain Sci. 2021 Sep 12;11(9):
pubmed: 34573221
Front Cell Neurosci. 2018 Dec 13;12:494
pubmed: 30618641
Pain. 2014 Sep;155(9):1861-1870
pubmed: 24973718
J Neurotrauma. 2018 Feb 1;35(3):582-592
pubmed: 29065765
Science. 2010 Dec 3;330(6009):1400-4
pubmed: 21127255
Annu Rev Neurosci. 2009;32:1-32
pubmed: 19400724
Recent Pat Drug Deliv Formul. 2016;10(1):11-23
pubmed: 26282464
Eur J Pain. 2017 Jan;21(1):29-44
pubmed: 27341614
Br J Clin Pharmacol. 2011 Nov;72(5):735-44
pubmed: 21426373
Anesth Analg. 1994 Oct;79(4):706-9
pubmed: 7943779
Curr Rheumatol Rep. 2007 Dec;9(6):488-96
pubmed: 18177603
Pain. 2000 Dec 15;89(1):1-5
pubmed: 11113287
Nano Today. 2021 Aug;39:
pubmed: 34899962
Nanoscale Res Lett. 2020 Jan 16;15(1):13
pubmed: 31950284
Arch Phys Med Rehabil. 1999 May;80(5):580-6
pubmed: 10326925
AAPS J. 2016 Nov;18(6):1373-1378
pubmed: 27480318
Biomaterials. 2008 Apr;29(12):1967-75
pubmed: 18255138
Sci Rep. 2016 Jan 06;6:18534
pubmed: 26732942
Life Sci. 2004 Apr 9;74(21):2605-10
pubmed: 15041442
Spinal Cord. 2009 May;47(5):352-9
pubmed: 19002150
Phys Life Rev. 2016 Mar;16:163-75
pubmed: 26708357
Brain Res Rev. 2009 Apr;60(1):202-13
pubmed: 19154757
Arq Neuropsiquiatr. 2013 Sep;71(9A):600-3
pubmed: 24141439
Pain. 2007 Nov;132(1-2):179-88
pubmed: 17845835
Am J Phys Med Rehabil. 2010 Oct;89(10):840-8
pubmed: 20855984
Pain. 2015 Jan;156(1):166-174
pubmed: 25599312
Br J Anaesth. 2017 Apr 1;118(4):504-516
pubmed: 28403399
J Neurosci. 2006 Nov 22;26(47):12165-73
pubmed: 17122041
Nat Rev Dis Primers. 2017 Apr 27;3:17018
pubmed: 28447605
J Neurosci Res. 2017 Jun;95(6):1330-1335
pubmed: 27574286
Nat Biomed Eng. 2017;1:644-653
pubmed: 29152410
Pain Ther. 2015 Jun;4(1):51-65
pubmed: 25744501
Pain. 2013 Dec;154 Suppl 1:S29-S43
pubmed: 24021862
Adv Drug Deliv Rev. 2019 Aug;148:38-59
pubmed: 30582938
Biomaterials. 2009 May;30(13):2582-90
pubmed: 19185913
Front Neurol. 2019 Apr 03;10:309
pubmed: 31001194
Pain. 2008 Jul 15;137(2):237-244
pubmed: 17942228
Biol Psychiatry. 2020 Jan 1;87(1):64-73
pubmed: 31806085
Lakartidningen. 2017 Jul 3;114:
pubmed: 28675414
Curr Pain Headache Rep. 2012 Jun;16(3):207-16
pubmed: 22392531
Pain. 2014 Feb;155(2):367-376
pubmed: 24472518
J Neurol Sci. 2018 Jan 15;384:75-83
pubmed: 29249383
J Neurosci. 2009 Sep 30;29(39):12125-30
pubmed: 19793970
Arch Phys Med Rehabil. 2014 Dec;95(12):2279-87
pubmed: 25159715
J Neurosci. 2004 Nov 17;24(46):10410-5
pubmed: 15548656
Annu Rev Biomed Eng. 2019 Jun 4;21:61-84
pubmed: 30786212
CNS Drugs. 2008;22(6):455-75
pubmed: 18484790
Mol Pain. 2017 Jan;13:1744806917697006
pubmed: 28326946
J Pain Res. 2019 May 27;12:1721-1732
pubmed: 31213884
Pain. 1999 Aug;Suppl 6:S141-S147
pubmed: 10491983
Front Neurosci. 2019 Jan 14;12:1038
pubmed: 30692907
Arch Phys Med Rehabil. 1998 Apr;79(4):395-401
pubmed: 9552104
Front Behav Neurosci. 2015 Aug 21;9:222
pubmed: 26347631
Science. 2000 Jun 9;288(5472):1765-9
pubmed: 10846153
J Control Release. 2015 Dec 10;219:141-154
pubmed: 26343846
J Clin Med. 2022 Jan 13;11(2):
pubmed: 35054089
J Invest Surg. 2021 Apr;34(4):380-392
pubmed: 31304811
P T. 2012 Sep;37(9):512-25
pubmed: 23066345
Spinal Cord. 2022 Jul;60(7):604-611
pubmed: 34183775
Eur J Pharmacol. 2001 Oct 19;429(1-3):23-37
pubmed: 11698024
Arch Phys Med Rehabil. 2007 Dec;88(12):1547-60
pubmed: 18047869
Local Reg Anesth. 2018 Aug 08;11:35-44
pubmed: 30122981
Int J Environ Res Public Health. 2021 Feb 13;18(4):
pubmed: 33668438
Acute Med Surg. 2017 Mar 06;4(2):152-160
pubmed: 29123854
J Pharm Sci. 2013 Jan;102(1):215-26
pubmed: 23108693
Neurology. 2013 Feb 5;80(6):533-9
pubmed: 23345639
J Pain. 2021 Jan;22(1):86-96
pubmed: 32629032
Eur J Pain. 2005 Aug;9(4):463-84
pubmed: 15979027
Pain Ther. 2017 Dec;6(Suppl 1):25-33
pubmed: 29178034
Nat Neurosci. 2002 Nov;5 Suppl:1062-7
pubmed: 12403987
Eur Neuropsychopharmacol. 2016 Feb;26(2):320-330
pubmed: 26708319
Int J Mol Sci. 2022 Apr 20;23(9):
pubmed: 35562941
Pain. 2003 Jun;103(3):249-257
pubmed: 12791431
Prog Brain Res. 2000;129:429-49
pubmed: 11098709
J Pers Med. 2022 Mar 01;12(3):
pubmed: 35330380
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2423-8
pubmed: 19171885
Lancet Neurol. 2012 Nov;11(11):999-1005
pubmed: 23079556
Acta Anaesthesiol Scand. 2004 Apr;48(4):498-506
pubmed: 15025615
Anesthesiology. 1992 Sep;77(3):529-35
pubmed: 1519790
Nanoscale. 2013 Oct 7;5(19):8821-36
pubmed: 23945984
Biomaterials. 2018 Nov;183:114-127
pubmed: 30153562
Prog Neurobiol. 2009 Feb;87(2):81-97
pubmed: 18952143
Spinal Cord. 2003 Nov;41(11):600-9
pubmed: 14569261
Neurology. 2002 Feb 26;58(4):554-63
pubmed: 11865132
J Pain Res. 2013 Nov 21;6:803-14
pubmed: 24294006
Neurology. 2000 Feb 8;54(3):564-74
pubmed: 10680784
Pain. 2013 Feb;154(2):204-212
pubmed: 23141478
Nature. 1998 Jul 16;394(6690):277-81
pubmed: 9685157
Clin J Pain. 2002 May-Jun;18(3):154-63
pubmed: 12048417
Pain Res Manag. 2004 Spring;9(1):39-45
pubmed: 15007402
Pain. 2009 Jan;141(1-2):52-9
pubmed: 19027233
Restor Neurol Neurosci. 2016 Apr 11;34(4):603-13
pubmed: 27080071
Pain. 2002 Apr;96(3):365-373
pubmed: 11973011
Anesthesiology. 2005 May;102(5):1023-30
pubmed: 15851891
Neurology. 2006 Nov 28;67(10):1792-800
pubmed: 17130411
Ther Adv Drug Saf. 2015 Apr;6(2):67-79
pubmed: 25922655
Annu Rev Pharmacol Toxicol. 2009;49:97-121
pubmed: 18834308
J Pain Symptom Manage. 2003 May;25(5 Suppl):S4-S11
pubmed: 12694987
J Pharm Sci. 2012 Mar;101(3):1157-65
pubmed: 22105694
Int J Dev Neurosci. 2013 Nov;31(7):701-13
pubmed: 23928260
J Neurosci. 2015 Jul 08;35(27):9957-65
pubmed: 26156996
Colloids Surf B Biointerfaces. 2014 Sep 1;121:66-73
pubmed: 24934456
J Neurotrauma. 2010 Apr;27(4):729-37
pubmed: 20059302
Nanomedicine. 2017 Nov;13(8):2623-2632
pubmed: 28756090
Neurorehabil Neural Repair. 2013 Oct;27(8):704-8
pubmed: 23757296
J Neurosci. 2006 Apr 19;26(16):4308-17
pubmed: 16624951
Paraplegia. 1982 Jun;20(3):135-46
pubmed: 6982450
Brain Sci. 2021 Aug 18;11(8):
pubmed: 34439702
Arch Phys Med Rehabil. 2014 Nov;95(11):2180-6
pubmed: 24992021
J Neurosci. 2008 Feb 6;28(6):1398-403
pubmed: 18256259
Lancet Neurol. 2015 Feb;14(2):162-73
pubmed: 25575710
Brain. 2010 Sep;133(9):2565-77
pubmed: 20685806
J Clin Med. 2019 Feb 03;8(2):
pubmed: 30717476
Science. 2012 Jul 20;337(6092):303-5
pubmed: 22822138
Pain. 2010 Sep;150(3):573-581
pubmed: 20705215
Pain. 1987 May;29(2):151-161
pubmed: 3302841
Front Neurol. 2019 Mar 22;10:272
pubmed: 30967836
Cent Nerv Syst Agents Med Chem. 2009 Mar;9(1):71-8
pubmed: 20021340
P T. 2017 Dec;42(12):742-755
pubmed: 29234213
Neurosurgery. 1995 Dec;37(6):1080-7
pubmed: 8584148
Curr Drug Targets. 2015;16(14):1671-81
pubmed: 26601723
Mayo Clin Proc. 2010 Mar;85(3 Suppl):S3-14
pubmed: 20194146
Ann Neurol. 2013 Nov;74(5):630-6
pubmed: 24018757
Mol Neurobiol. 2020 Apr;57(4):1978-1985
pubmed: 31900861