A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells.
MEK inhibition
colorectal liver metastases
patient-derived xenograft model
tissue-resident memory T cells
tumor-infiltrating lymphocytes
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Jun 2022
10 Jun 2022
Historique:
received:
30
04
2022
revised:
29
05
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
The diversity of T cells in the human liver may reflect the composition of TILs in CRLM. Our ex vivo characterization of CRLM vs. adjacent liver tissue detected CD103+CD39+CD8+ T
Identifiants
pubmed: 35740548
pii: cancers14122882
doi: 10.3390/cancers14122882
pmc: PMC9221137
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Cancer Society
ID : 2018/724
Organisme : Swedish Cancer Society
ID : 2018/652
Organisme : The Swedish State under the agreement between Swedish government and the county councils- the ALF agreement
ID : ALFGBG-723231
Organisme : The Swedish State under the agreement between Swedish government and the county councils- the ALF agreement
ID : ALFGBG-719301
Organisme : The Sjöberg Foundation
ID : 2020-160
Organisme : Swedish Society of Medical Research
ID : P17-0024
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