Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism.
ACSS2
inhibitor
metabolism
targeted therapy
tumor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Jun 2022
12 Jun 2022
Historique:
received:
06
05
2022
revised:
04
06
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Acetyl-CoA Synthetase 2 (ACSS2) belongs to a member of the acyl-CoA short-chain synthase family, which can convert acetate in the cytoplasm and nucleus into acetyl-CoA. It has been proven that ACSS2 is highly expressed in glioblastoma, breast cancer, liver cancer, prostate cancer, bladder cancer, renal cancer, and other tumors, and is closely related to tumor stage and the overall survival rate of patients. Accumulating studies show that hypoxia and a low serum level induce ACSS2 expression to help tumor cells cope with this nutrient-poor environment. The potential mechanisms are associated with the ability of ACSS2 to promote the synthesis of lipids in the cytoplasm, induce the acetylation of histones in the nucleus, and facilitate the expression of autophagy genes. Novel-specific inhibitors of ACSS2 are developed and confirmed to the effectiveness in pre-clinical tumor models. Targeting ACSS2 may provide novel approaches for tumor treatment. This review summarizes the biological function of ACSS2, its relation to survival and prognosis in different tumors, and how ACSS2 mediates different pathways to promote tumor metastasis, invasion, and drug resistance.
Identifiants
pubmed: 35740562
pii: cancers14122896
doi: 10.3390/cancers14122896
pmc: PMC9221533
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : the National Natural Science Foundation of China
ID : 81572956
Organisme : the National Natural Science Foundation of China
ID : 81701945
Organisme : the Jiangsu Provincial Science and Technology Supporting Program
ID : BE2017696
Organisme : the Medical Innovation Team of Jiangsu Province
ID : CXTDC2016009
Organisme : Zhenjiang Key Research and Development Program
ID : SH2020067
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