Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection.
COVID-19
T cells
chronic obstructive pulmonary disease (COPD)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
received:
01
05
2022
revised:
01
06
2022
accepted:
03
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
People with pre-existing lung diseases such as chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19). Still, an interrogation of the immune response to COVID-19 infection, spatially throughout the lung structure, is lacking in patients with COPD. For this study, we characterized the immune microenvironment of the lung parenchyma, airways, and vessels of never- and ever-smokers with or without COPD, all of whom died of COVID-19, using spatial transcriptomic and proteomic profiling. The parenchyma, airways, and vessels of COPD patients, compared to control lungs had (1) significant enrichment for lung-resident CD45RO
Identifiants
pubmed: 35740993
pii: cells11121864
doi: 10.3390/cells11121864
pmc: PMC9220844
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149744
Pays : United States
Références
Nat Rev Immunol. 2006 Sep;6(9):644-58
pubmed: 16932750
Nature. 2020 Aug;584(7821):457-462
pubmed: 32668444
Cell Mol Immunol. 2014 Nov;11(6):606-8
pubmed: 24658432
Am J Respir Crit Care Med. 2015 Sep 15;192(6):695-705
pubmed: 26073875
Nat Immunol. 2022 Feb;23(2):186-193
pubmed: 35105982
Immunobiology. 2014 Dec;219(12):975-9
pubmed: 25097153
Cell. 2020 Jul 23;182(2):429-446.e14
pubmed: 32526206
Mayo Clin Proc. 2018 Oct;93(10):1488-1502
pubmed: 30286833
Eur J Pharmacol. 2021 Oct 5;908:174374
pubmed: 34303662
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1434-1439
pubmed: 31348682
Am J Med. 2018 Sep;131(9S):1-6
pubmed: 29778456
J Immunol. 2021 Jul 15;207(2):523-533
pubmed: 34193602
Thorax. 2021 Oct;76(10):1010-1019
pubmed: 33846275
Turk J Med Sci. 2020 May 12;50(4):664-678
pubmed: 32394687
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nat Commun. 2021 May 21;12(1):3010
pubmed: 34021148
Lancet Respir Med. 2018 Aug;6(8):591-602
pubmed: 30072106
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Cancer Res. 2012 Aug 1;72(15):3753-63
pubmed: 22659451
Free Radic Biol Med. 2021 Aug 20;172:688-698
pubmed: 34186206
Eur Respir J. 2008 Mar;31(3):555-62
pubmed: 18057064
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):822-6
pubmed: 9517597
J Exp Med. 2018 Mar 5;215(3):773-783
pubmed: 29440362
Immunity. 2020 Dec 15;53(6):1258-1271.e5
pubmed: 33296686
Eur Respir J. 2005 Mar;25(3):441-6
pubmed: 15738286
EClinicalMedicine. 2020 Sep;26:100515
pubmed: 32869011
Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666
pubmed: 34033525
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Nature. 2005 Apr 7;434(7034):772-7
pubmed: 15800576
J Immunol. 2008 Feb 1;180(3):1662-9
pubmed: 18209062
Nat Immunol. 2016 Nov;17(11):1322-1333
pubmed: 27595233
Nature. 2021 May;593(7860):564-569
pubmed: 33780969
Front Microbiol. 2020 Oct 23;11:550674
pubmed: 33193132