Fission Impossible (?)-New Insights into Disorders of Peroxisome Dynamics.
ACBD5
FIS1
PEX11β
division defects
dynamin-related protein 1
membrane fission
mitochondria
mitochondrial fission factor
organelle dynamics
peroxisomes
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
14 06 2022
14 06 2022
Historique:
received:
18
05
2022
revised:
09
06
2022
accepted:
10
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Peroxisomes are highly dynamic and responsive organelles, which can adjust their morphology, number, intracellular position, and metabolic functions according to cellular needs. Peroxisome multiplication in mammalian cells involves the concerted action of the membrane-shaping protein PEX11β and division proteins, such as the membrane adaptors FIS1 and MFF, which recruit the fission GTPase DRP1 to the peroxisomal membrane. The latter proteins are also involved in mitochondrial division. Patients with loss of DRP1, MFF or PEX11β function have been identified, showing abnormalities in peroxisomal (and, for the shared proteins, mitochondrial) dynamics as well as developmental and neurological defects, whereas the metabolic functions of the organelles are often unaffected. Here, we provide a timely update on peroxisomal membrane dynamics with a particular focus on peroxisome formation by membrane growth and division. We address the function of PEX11β in these processes, as well as the role of peroxisome-ER contacts in lipid transfer for peroxisomal membrane expansion. Furthermore, we summarize the clinical phenotypes and pathophysiology of patients with defects in the key division proteins DRP1, MFF, and PEX11β as well as in the peroxisome-ER tether ACBD5. Potential therapeutic strategies for these rare disorders with limited treatment options are discussed.
Identifiants
pubmed: 35741050
pii: cells11121922
doi: 10.3390/cells11121922
pmc: PMC9221819
pii:
doi:
Substances chimiques
Membrane Proteins
0
Mitochondrial Proteins
0
GTP Phosphohydrolases
EC 3.6.1.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R016844/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T002255/1
Pays : United Kingdom
Références
J Am Heart Assoc. 2013 Oct 08;2(5):e000461
pubmed: 24103571
Nat Rev Neurol. 2015 Jan;11(1):11-24
pubmed: 25486875
Protein J. 2019 Jun;38(3):289-305
pubmed: 31203484
PLoS One. 2018 Dec 27;13(12):e0209507
pubmed: 30589881
Nat Biotechnol. 2019 Nov;37(11):1361-1371
pubmed: 31690884
Biol Open. 2013 Aug 14;2(10):998-1006
pubmed: 24167709
Int J Appl Basic Med Res. 2021 Apr-Jun;11(2):114-116
pubmed: 33912434
Biochem Genet. 2018 Apr;56(1-2):56-77
pubmed: 29110115
Biochim Biophys Acta. 2016 May;1863(5):971-83
pubmed: 26409486
Mol Cell Biol. 2002 Jun;22(12):4358-65
pubmed: 12024045
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):594-603
pubmed: 28129423
Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118675
pubmed: 32044385
J Cell Biol. 2015 Nov 23;211(4):795-805
pubmed: 26598616
Mol Cell Biol. 2005 Dec;25(24):10822-32
pubmed: 16314507
J Cell Biol. 2018 Feb 5;217(2):619-633
pubmed: 29222186
Eur J Cell Biol. 1998 Feb;75(2):87-96
pubmed: 9548366
J Cell Sci. 2004 Aug 1;117(Pt 17):3995-4006
pubmed: 15286177
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1342-51
pubmed: 23530241
Science. 2016 Jul 15;353(6296):aaf5549
pubmed: 27418514
J Biol Chem. 2010 Oct 15;285(42):32494-503
pubmed: 20696759
Front Cell Dev Biol. 2020 Oct 23;8:577637
pubmed: 33195217
Hum Mutat. 2019 May;40(5):601-618
pubmed: 30801875
J Cell Biol. 2000 May 1;149(3):707-18
pubmed: 10791983
EMBO J. 2011 Jan 5;30(1):5-16
pubmed: 21113128
Eur J Hum Genet. 2016 Jul;24(7):1084-8
pubmed: 26604000
Mol Genet Genomic Med. 2020 Jan;8(1):
pubmed: 31724321
Nat Commun. 2018 Nov 6;9(1):4634
pubmed: 30401830
J Cell Sci. 2012 Feb 1;125(Pt 3):589-602
pubmed: 22389399
Traffic. 2009 Nov;10(11):1722-33
pubmed: 19719477
J Cell Sci. 2010 Aug 15;123(Pt 16):2750-62
pubmed: 20647371
Annu Rev Biochem. 2006;75:295-332
pubmed: 16756494
Int J Mol Sci. 2020 Oct 28;21(21):
pubmed: 33126676
Eur J Cell Biol. 1996 Jan;69(1):24-35
pubmed: 8825021
Biochim Biophys Acta. 2016 May;1863(5):922-33
pubmed: 26611709
J Cell Sci. 2022 Jul 1;135(13):
pubmed: 35678336
J Cell Biol. 2013 Mar 4;200(5):651-66
pubmed: 23460677
Nat Commun. 2018 May 2;9(1):1761
pubmed: 29720625
J Inherit Metab Dis. 2018 May;41(3):479-487
pubmed: 28849344
Dev Cell. 2017 Mar 27;40(6):583-594.e6
pubmed: 28350990
J Cell Biol. 2021 May 3;220(5):
pubmed: 33891013
Microsc Res Tech. 2003 Jun 1;61(2):171-8
pubmed: 12740823
Mov Disord. 2017 Jul;32(7):1108-1110
pubmed: 28436574
J Biol Chem. 2015 May 1;290(18):11692-703
pubmed: 25770210
Exp Cell Res. 2007 May 1;313(8):1675-86
pubmed: 17408615
Histochem Cell Biol. 2009 Apr;131(4):441-6
pubmed: 19219450
Nature. 2018 Jun;558(7710):401-405
pubmed: 29899447
FEBS Lett. 2021 Apr;595(8):1184-1204
pubmed: 33742459
J Cell Biol. 2018 Jan 2;217(1):251-268
pubmed: 29142021
Subcell Biochem. 2018;89:345-365
pubmed: 30378031
Traffic. 2012 Jul;13(7):960-78
pubmed: 22435684
Hum Mol Genet. 2009 Oct 15;18(R2):R169-76
pubmed: 19808793
J Cell Biol. 2022 Mar 7;221(3):
pubmed: 35019937
Am J Med Genet A. 2016 Aug;170(8):2002-11
pubmed: 27145208
J Child Neurol. 2018 Sep;33(10):651-658
pubmed: 29877124
Biochim Biophys Acta. 2016 May;1863(5):1019-26
pubmed: 26616035
J Cell Biol. 2018 Oct 1;217(10):3625-3639
pubmed: 30093493
Eur J Cell Biol. 1987 Jun;43(3):293-300
pubmed: 3622522
EMBO J. 2013 May 2;32(9):1280-92
pubmed: 23584531
Molecules. 2019 Jul 12;24(14):
pubmed: 31336903
Eur J Cell Biol. 1994 Aug;64(2):281-94
pubmed: 7813516
J Lipid Res. 2021;62:100030
pubmed: 33556440
Cell. 2010 May 14;141(4):668-81
pubmed: 20451243
Pharmacol Ther. 2021 Mar;219:107705
pubmed: 33039420
J Cell Biol. 2017 Feb;216(2):331-342
pubmed: 28108524
Histochem Cell Biol. 2017 Sep;148(3):331-341
pubmed: 28523458
J Cell Biol. 2017 Feb;216(2):367-377
pubmed: 28108526
Mol Cell Biol. 2002 Dec;22(23):8226-40
pubmed: 12417726
Commun Biol. 2020 Nov 26;3(1):713
pubmed: 33244184
Anal Bioanal Chem. 2022 Mar;414(6):2235-2250
pubmed: 35083512
Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1292-1300
pubmed: 29501607
J Cell Biol. 1998 Oct 19;143(2):351-8
pubmed: 9786947
J Cell Sci. 2013 Jan 1;126(Pt 1):176-85
pubmed: 23077178
J Cell Sci. 2017 May 1;130(9):1675-1687
pubmed: 28325759
J Biol Chem. 2017 Jan 13;292(2):691-705
pubmed: 27899449
J Cell Biol. 2009 Sep 21;186(6):805-16
pubmed: 19752021
Hum Mol Genet. 2011 Jul 1;20(13):2495-509
pubmed: 21459773
Cold Spring Harb Mol Case Stud. 2019 Jun 3;5(3):
pubmed: 30850373
EMBO Rep. 2007 Oct;8(10):939-44
pubmed: 17721437
Curr Treat Options Neurol. 2009 Nov;11(6):414-30
pubmed: 19891905
Traffic. 2018 Mar;19(3):229-242
pubmed: 29364559
Hum Mol Genet. 2018 Nov 1;27(21):3710-3719
pubmed: 30085106
Clin Genet. 2016 Nov;90(5):472-474
pubmed: 27301544
J Med Genet. 2017 May;54(5):330-337
pubmed: 27799409
Science. 2016 Jan 15;351(6270):275-281
pubmed: 26816379
EMBO Rep. 2021 Oct 5;22(10):e51991
pubmed: 34351705
Essays Biochem. 2018 Jul 20;62(3):341-360
pubmed: 30030364
Brain. 2017 Oct 1;140(10):2586-2596
pubmed: 28969390
Cell Rep. 2021 Apr 13;35(2):108947
pubmed: 33852852
FEBS Lett. 2011 Jul 21;585(14):2205-11
pubmed: 21620837
Am J Med Genet A. 2021 Apr;185(4):1236-1241
pubmed: 33427402
Subcell Biochem. 2018;89:367-382
pubmed: 30378032
Biochim Biophys Acta. 2016 Feb;1863(2):271-83
pubmed: 26597702
Gut. 1991 Aug;32(8):858-65
pubmed: 1885066
J Cell Sci. 2000 Oct;113 ( Pt 20):3663-71
pubmed: 11017881
J Cell Sci. 2022 Mar 1;135(5):
pubmed: 34672330
J Cell Biol. 2010 Dec 13;191(6):1141-58
pubmed: 21149567
J Cell Biol. 2021 May 3;220(5):
pubmed: 33891012
Folia Histochem Cytobiol. 1995;33(4):255-8
pubmed: 8851054
Mol Biol Cell. 2013 Mar;24(5):659-67
pubmed: 23283981
Biochim Biophys Acta. 2012 Sep;1822(9):1430-41
pubmed: 22871920
Nat Genet. 1995 Feb;9(2):115-25
pubmed: 7719337
Cells. 2021 Aug 30;10(9):
pubmed: 34571897
Exp Ther Med. 2022 Apr;23(4):307
pubmed: 35340870
Dev Dyn. 2018 Jan;247(1):47-53
pubmed: 28643345
J Cell Mol Med. 2019 Mar;23(3):2020-2031
pubmed: 30585412
Clin Genet. 2020 Jun;97(6):933-937
pubmed: 32181496
Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118800
pubmed: 32712071
Front Cell Dev Biol. 2016 Feb 04;4:6
pubmed: 26870732
Trends Cell Biol. 2021 Aug;31(8):656-670
pubmed: 33674166
EMBO Rep. 2020 Feb 5;21(2):e49865
pubmed: 31894645
PLoS One. 2013;8(1):e53424
pubmed: 23308220
J Mol Biol. 2015 Jun 5;427(11):2072-87
pubmed: 25769804
Acta Pharmacol Sin. 2021 May;42(5):655-664
pubmed: 32913266
Plant Physiol. 2016 Jul;171(3):1665-74
pubmed: 27208303
J Inherit Metab Dis. 2020 Jan;43(1):71-89
pubmed: 30864148
Biol Open. 2015 Apr 24;4(6):710-21
pubmed: 25910939
Invest Ophthalmol Vis Sci. 1977 Dec;16(12):1110-7
pubmed: 924741
EMBO J. 2013 May 29;32(11):1514-28
pubmed: 23524851
Nat Commun. 2018 Apr 26;9(1):1677
pubmed: 29700304
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12843-8
pubmed: 18728184
J Cell Sci. 2018 Oct 29;131(21):
pubmed: 30373893
Nat Commun. 2014 Dec 17;5:5790
pubmed: 25517356
Dev Disabil Res Rev. 2010;16(2):120-8
pubmed: 20818726
J Med Genet. 2012 Apr;49(4):234-41
pubmed: 22499341
J Biol Chem. 2016 Jan 1;291(1):478-92
pubmed: 26578514
Science. 1988 Mar 25;239(4847):1536-8
pubmed: 3281254
Ann Clin Transl Neurol. 2020 Jan;7(1):144-152
pubmed: 31912665
Mol Ther Methods Clin Dev. 2021 Sep 07;23:225-240
pubmed: 34703844
Bioessays. 2007 Nov;29(11):1105-14
pubmed: 17935214
Nat Commun. 2018 Dec 7;9(1):5239
pubmed: 30531964
Biochim Biophys Acta. 2014 Aug;1842(8):1179-85
pubmed: 24326103
J Med Genet. 2012 May;49(5):307-13
pubmed: 22581968
Curr Biol. 2008 Jan 22;18(2):102-8
pubmed: 18207745
Contact (Thousand Oaks). 2019 Jun 5;2:
pubmed: 31198905
J Inherit Metab Dis. 2015 Jul;38(4):681-702
pubmed: 25687155
Am J Med Genet A. 2016 Jun;170(6):1603-7
pubmed: 26992161
J Biol Chem. 2016 Jan 1;291(1):493-507
pubmed: 26578513
Nature. 2017 Feb 9;542(7640):251-254
pubmed: 28146471
J Cell Biol. 2007 May 7;177(3):439-50
pubmed: 17470634
Hum Mol Genet. 2017 Nov 1;26(21):4118-4131
pubmed: 28973308
J Pediatr Endocrinol Metab. 2021 Oct 20;35(1):11-18
pubmed: 34668366
Mol Biol Cell. 2021 Oct 1;32(20):ar5
pubmed: 34347505
Oncotarget. 2017 Dec 22;9(5):6128-6143
pubmed: 29464060
J Integr Plant Biol. 2012 Nov;54(11):851-67
pubmed: 23046073
Cells. 2020 Jan 27;9(2):
pubmed: 32012656
Int J Mol Sci. 2020 Jul 30;21(15):
pubmed: 32751702
Mol Biol Cell. 2008 Jun;19(6):2402-12
pubmed: 18353969
Front Endocrinol (Lausanne). 2021 Mar 25;12:660095
pubmed: 33841340
Ann Neurol. 1999 Jan;45(1):100-10
pubmed: 9894883
EMBO Rep. 2013 Jun;14(6):545-52
pubmed: 23628762
Int Rev Cytol. 2006;255:237-90
pubmed: 17178468
Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118709
pubmed: 32224193
J Pediatr. 2016 Apr;171:313-6.e1-2
pubmed: 26825290
Hum Mol Genet. 2020 Jan 15;29(2):177-188
pubmed: 31868880
Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E187-96
pubmed: 23169785
Nat Rev Neurosci. 2012 Jan 05;13(2):77-93
pubmed: 22218207
Mol Biol Cell. 2005 Nov;16(11):5077-86
pubmed: 16107562
J Biol Chem. 2007 Apr 13;282(15):11521-9
pubmed: 17301055
Science. 2013 Jan 25;339(6118):464-7
pubmed: 23349293
Dis Model Mech. 2012 Jan;5(1):125-40
pubmed: 21954064
Nat Commun. 2014 Nov 05;5:5244
pubmed: 25370169
Small GTPases. 2021 Sep-Nov;12(5-6):372-398
pubmed: 33183150
Nat Commun. 2018 Nov 27;9(1):5008
pubmed: 30479337
Trends Cell Biol. 2013 Feb;23(2):64-71
pubmed: 23159640
Eur J Cell Biol. 1988 Apr;46(1):136-43
pubmed: 3260863
Cell. 2015 Nov 5;163(4):894-906
pubmed: 26544938
Science. 2011 Oct 21;334(6054):358-62
pubmed: 21885730
J Cell Sci. 2016 Jun 1;129(11):2170-81
pubmed: 27076521
Annu Rev Cell Biol. 1985;1:489-530
pubmed: 3916321
Biochim Biophys Acta. 2016 May;1863(5):934-55
pubmed: 26686055
J Biol Chem. 1998 Nov 6;273(45):29607-14
pubmed: 9792670
Proc Natl Acad Sci U S A. 2015 May 19;112(20):6377-82
pubmed: 25941407
Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182991
pubmed: 31129117
Int J Mol Sci. 2017 May 24;18(6):
pubmed: 28538669
J Cell Biol. 2017 Dec 4;216(12):4123-4139
pubmed: 29158231
Front Physiol. 2022 Feb 03;13:834411
pubmed: 35185625
Front Genet. 2018 Dec 07;9:625
pubmed: 30581454
Hum Mol Genet. 2016 May 1;25(9):1846-56
pubmed: 26931468
Subcell Biochem. 2018;89:383-415
pubmed: 30378033
J Biol Chem. 2013 Sep 20;288(38):27584-27593
pubmed: 23921378
J Mol Med (Berl). 2022 Jan;100(1):1-21
pubmed: 34657190
Cell Cycle. 2017 Jun 3;16(11):1039-1045
pubmed: 28463579
J Biol Chem. 2003 Mar 7;278(10):8597-605
pubmed: 12499366
Cell Mol Life Sci. 2021 Mar;78(5):1929-1941
pubmed: 33141311
J Cell Sci. 2012 Aug 15;125(Pt 16):3813-26
pubmed: 22595523
Histol Histopathol. 2012 Jun;27(6):661-76
pubmed: 22473689
Genome Res. 2013 Feb;23(2):236-47
pubmed: 23105016
N Engl J Med. 2007 Apr 26;356(17):1736-41
pubmed: 17460227
J Cell Sci. 2017 Sep 15;130(18):2953-2960
pubmed: 28842472
Hum Mutat. 2016 Sep;37(9):898-903
pubmed: 27328748
J Cell Biol. 1969 Aug;42(2):501-18
pubmed: 5792337
J Histochem Cytochem. 1999 Sep;47(9):1141-8
pubmed: 10449535
J Med Genet. 2016 Apr;53(4):270-8
pubmed: 26783368