A Fluorescence-Based Competitive Antibody Binding Assay for Kynurenine, a Potential Biomarker of Kidney Transplant Failure.
amino acids
biomarkers
fluorescence
fluorescent probes
kynurenine
rapid testing
transplant failure
transplant medicine
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
02 Jun 2022
02 Jun 2022
Historique:
received:
22
03
2022
revised:
13
05
2022
accepted:
29
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming. Herein, we report the successful synthesis of a fluorescently labelled kynurenine derivative, showing proper fluorescence and anti-kynurenine antibody binding behavior in a magnetic bead immunoassay (MIA). The fluorescent kynurenine-rhodamine B conjugate shows a K
Identifiants
pubmed: 35741190
pii: diagnostics12061380
doi: 10.3390/diagnostics12061380
pmc: PMC9221851
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Economics, Labor and Housing Baden-Württemberg
ID : 35-4223.10/10
Organisme : Federal Ministry for Economic Affairs and Climate Action, Germany
ID : 20934 N
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