The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?
caloric restriction
centenarians
health span
insulin sensitivity
longevity
metabolism
signaling pathways
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jun 2022
11 Jun 2022
Historique:
received:
23
05
2022
revised:
07
06
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Striving for longevity is neither a recent human desire nor a novel scientific field. The first article on this topic was published in 1838, when the average human life expectancy was approximately 40 years. Although nowadays people on average live almost as twice as long, we still (and perhaps more than ever) look for new ways to extend our lifespan. During this seemingly endless journey of discovering efficient methods to prolong life, humans were enthusiastic regarding several approaches, one of which is caloric restriction (CR). Where does CR, initially considered universally beneficial for extending both lifespan and health span, stand today? Does a lifelong decrease in food consumption represent one of the secrets of centenarians' long and healthy life? Do we still believe that if we eat less, we will live longer? This review aims to summarize the current literature on CR as a potential life-prolonging intervention in humans and discusses metabolic pathways that underlie this effect.
Identifiants
pubmed: 35742989
pii: ijms23126546
doi: 10.3390/ijms23126546
pmc: PMC9223351
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-68/2022-14/200007
Références
Exp Mol Med. 2016 Jul 15;48(7):e245
pubmed: 27416781
Aging Cell. 2015 Aug;14(4):707-9
pubmed: 25808402
Science. 2009 Jul 10;325(5937):201-4
pubmed: 19590001
Okinawan J Am Stud. 2007;4:60-72
pubmed: 34629932
Aging Cell. 2019 Jun;18(3):e12944
pubmed: 30938024
Cold Spring Harb Perspect Biol. 2014 Jan 01;6(1):
pubmed: 24384568
Curr Biol. 2004 May 25;14(10):885-90
pubmed: 15186745
J Gerontol. 1993 Jan;48(1):B17-26
pubmed: 8418134
Cell Metab. 2012 May 2;15(5):713-24
pubmed: 22560223
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42
pubmed: 18316725
Cell Metab. 2016 Mar 8;23(3):529-40
pubmed: 26959186
Gerontology. 2012;58(2):126-8
pubmed: 21701153
Cell. 2022 Apr 28;185(9):1455-1470
pubmed: 35487190
Age Ageing. 2016 Jul;45(4):443-7
pubmed: 27130207
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11533-7
pubmed: 1454844
Physiology (Bethesda). 2011 Aug;26(4):214-24
pubmed: 21841070
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Nat Commun. 2013;4:2192
pubmed: 23900241
Cell. 2015 Feb 26;160(5):842-855
pubmed: 25723162
Aging (Albany NY). 2016 Mar;8(3):510-9
pubmed: 26979133
Exp Gerontol. 2004 Sep;39(9):1423-9
pubmed: 15489066
Mech Ageing Dev. 2022 Jun;204:111666
pubmed: 35331743
Mech Ageing Dev. 2017 Jul;165(Pt B):59-67
pubmed: 28315698
J Gerontol A Biol Sci Med Sci. 2006 Sep;61(9):943-50
pubmed: 16960025
BMC Genomics. 2019 Mar 8;20(1):197
pubmed: 30849937
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097-104
pubmed: 26187233
J Biol Chem. 2010 Oct 29;285(44):33959-70
pubmed: 20817729
Biochim Biophys Acta. 2010 Aug;1804(8):1576-83
pubmed: 19782772
Sci Rep. 2019 May 24;9(1):7824
pubmed: 31127145
Inflamm Res. 2009 Mar;58(3):143-50
pubmed: 19199090
Cell Rep. 2017 Jul 11;20(2):451-463
pubmed: 28700945
Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E108-16
pubmed: 19887594
Br Foreign Med Rev. 1838 Apr;5(10):380-413
pubmed: 30161568
J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):B10-9
pubmed: 9008653
Transl Med Aging. 2020;4:103-116
pubmed: 32832742
Nature. 2009 Jul 16;460(7253):392-5
pubmed: 19587680
Aging Cell. 2021 Feb;20(2):e13290
pubmed: 33512769
Lancet Diabetes Endocrinol. 2019 Sep;7(9):673-683
pubmed: 31303390
J Am Geriatr Soc. 1999 Jul;47(7):896-903
pubmed: 10404938
Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73
pubmed: 34518687
Annu Rev Pathol. 2010;5:253-95
pubmed: 20078221
Cell Metab. 2018 Apr 3;27(4):805-815.e4
pubmed: 29576535
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):877-91
pubmed: 23239824
Genome Biol. 2017 Mar 28;18(1):58
pubmed: 28351383
Antioxid Redox Signal. 2011 Jan 15;14(2):275-87
pubmed: 20518700
Biochem J. 2016 Jan 15;473(2):189-99
pubmed: 26542978
Nature. 2012 Sep 13;489(7415):318-21
pubmed: 22932268
Am J Hum Biol. 2012 Mar-Apr;24(2):101-6
pubmed: 22290875
Eur J Clin Nutr. 1994 Feb;48(2):138-48
pubmed: 8194495
Nutr Metab (Lond). 2012 Jun 29;9(1):64
pubmed: 22748184
Curr Biol. 2007 Oct 9;17(19):1646-56
pubmed: 17900900
Cell Metab. 2017 Sep 5;26(3):539-546.e5
pubmed: 28877457
Contemp Clin Trials. 2011 Nov;32(6):874-81
pubmed: 21767664
Nat Commun. 2018 Jun 19;9(1):2394
pubmed: 29921922
Arch Intern Med. 1998 Apr 27;158(8):900-6
pubmed: 9570177
J Psychiatr Res. 2020 Sep;128:16-22
pubmed: 32485641
Development. 2004 Aug;131(16):3897-906
pubmed: 15253933
Elife. 2021 May 04;10:
pubmed: 33941312
Science. 2007 Jul 20;317(5836):369-72
pubmed: 17641201
Cell Rep. 2013 Sep 12;4(5):913-20
pubmed: 23994476
J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1059-70
pubmed: 17921417
Nutrients. 2020 Oct 30;12(11):
pubmed: 33143083
J Cell Physiol. 2013 Dec;228(12):2262-70
pubmed: 23696314
Metabolism. 1997 Nov;46(11):1281-6
pubmed: 9361686
J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):338-49
pubmed: 18426957
Genome Biol. 2017 Mar 28;18(1):56
pubmed: 28351387
Aging (Albany NY). 2011 Apr;3(4):374-9
pubmed: 21483032
Cell Metab. 2018 Sep 4;28(3):337-352
pubmed: 30184484
Curr Biol. 2016 Jun 6;26(11):1480-5
pubmed: 27185560
Prev Med. 1978 Jun;7(2):205-17
pubmed: 674107
Front Med. 2018 Dec;12(6):634-644
pubmed: 30446879
Ann N Y Acad Sci. 2007 Oct;1114:434-55
pubmed: 17986602
Aging (Albany NY). 2020 Mar 16;12(6):4778-4793
pubmed: 32176868
J Nutr. 2006 Feb;136(2):343-52
pubmed: 16424110
Nature. 2003 Jan 9;421(6919):182-7
pubmed: 12483226
J Clin Endocrinol Metab. 2001 Jan;86(1):355-62
pubmed: 11232024
Aging Cell. 2015 Aug;14(4):497-510
pubmed: 25902704
Cell Metab. 2020 Jul 7;32(1):100-116.e4
pubmed: 32413334
Curr Vasc Pharmacol. 2014;12(5):674-81
pubmed: 24350933
Nutr J. 2011 Oct 07;10:107
pubmed: 21981968
Nutr Rev. 2021 Jan 1;79(1):98-113
pubmed: 32940695
Biogerontology. 2006 Jun;7(3):173-7
pubmed: 16810568
Exp Gerontol. 2007 Nov;42(11):1063-71
pubmed: 17709221
Science. 2003 Jan 24;299(5606):572-4
pubmed: 12543978
Expert Rev Endocrinol Metab. 2021 May;16(3):95-108
pubmed: 33957841
Curr Genomics. 2007 Nov;8(7):423-8
pubmed: 19412415
Science. 2001 Apr 6;292(5514):107-10
pubmed: 11292875
Cell Metab. 2005 Aug;2(2):105-17
pubmed: 16098828
Br J Nutr. 2018 Nov;120(10):1081-1097
pubmed: 30401007
J Gerontol A Biol Sci Med Sci. 2022 May 5;77(5):947-955
pubmed: 34957511
Aging (Albany NY). 2011 Mar;3(3):223-36
pubmed: 21415464
FEBS Open Bio. 2022 Apr;12(4):739-757
pubmed: 34878722
Ann N Y Acad Sci. 2004 Jun;1019:443-7
pubmed: 15247063
Aging (Albany NY). 2016 Jul;8(7):1416-31
pubmed: 27410480
Nutrients. 2020 Jun 01;12(6):
pubmed: 32492804
Am J Clin Nutr. 2021 Oct 4;114(4):1295-1303
pubmed: 34159359
J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1036-1044
pubmed: 29415252
Cell Metab. 2014 Jul 1;20(1):10-25
pubmed: 24726383
Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1032-7
pubmed: 15251868
PLoS One. 2013 Jul 30;8(7):e69178
pubmed: 23935948
Am J Clin Nutr. 2011 Apr;93(4):891S-6
pubmed: 21325438
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Nutr Rev. 2006 Feb;64(2 Pt 2):S27-47
pubmed: 16532897
Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96
pubmed: 16493415
Curr Atheroscler Rep. 2018 May 4;20(6):28
pubmed: 29728772
FASEB J. 2000 Sep;14(12):1825-36
pubmed: 10973932
Genome Biol. 2015 Dec 22;16:285
pubmed: 26694192
Nutr J. 2010 Nov 22;9:57
pubmed: 21092212
Cell Metab. 2016 May 10;23(5):821-36
pubmed: 27133129
Biogerontology. 2006 Jun;7(3):169-71
pubmed: 16680522
Microbiome. 2018 Mar 21;6(1):54
pubmed: 29562943
Mech Ageing Dev. 2017 Jul;165(Pt B):68-74
pubmed: 28461103
Br J Nutr. 2018 Oct;120(8):841-854
pubmed: 30157978
Front Physiol. 2020 Jun 16;11:506
pubmed: 32612534
Cell Metab. 2010 Dec 1;12(6):662-7
pubmed: 21109198
JAMA Intern Med. 2017 Nov 1;177(11):1650-1657
pubmed: 28975207
Nature. 2004 Jun 17;429(6993):771-6
pubmed: 15175761
Arch Med Sci. 2017 Aug;13(5):1130-1141
pubmed: 28883855
Expert Opin Ther Targets. 2017 Apr;21(4):371-380
pubmed: 28281903
Am J Epidemiol. 2014 Nov 15;180(10):978-88
pubmed: 25318818
Cardiol Res Pract. 2011 Feb 24;2011:679187
pubmed: 21403883
Nat Med. 2019 Aug;25(8):1234-1242
pubmed: 31332389
Curr Vasc Pharmacol. 2014;12(5):707-17
pubmed: 24350927
Maturitas. 2017 Oct;104:90-95
pubmed: 28923181
PLoS Genet. 2014 Feb 06;10(2):e1004109
pubmed: 24516399
Curr Gerontol Geriatr Res. 2019 Nov 30;2019:8194310
pubmed: 31885554
Nutrients. 2019 Jul 31;11(8):
pubmed: 31370376
J Am Coll Nutr. 1997 Jun;16(3):229-35
pubmed: 9176829
Adv Nutr. 2019 Nov 1;10(6):1029-1039
pubmed: 31111871
Public Health Nutr. 2014 Dec;17(12):2769-82
pubmed: 24476641
Exp Gerontol. 2006 Aug;41(8):727-36
pubmed: 16793232
Science. 2010 Feb 19;327(5968):1000-4
pubmed: 20167786
Aging Cell. 2017 Aug;16(4):761-772
pubmed: 28544360
Gut Microbes. 2018 Mar 4;9(2):104-114
pubmed: 28891744
Cardiovasc Diabetol. 2018 Aug 31;17(1):122
pubmed: 30170598
Interdiscip Top Gerontol. 2014;39:198-211
pubmed: 24862022
EMBO J. 2007 Apr 4;26(7):1913-23
pubmed: 17347648
Biogerontology. 2006 Jun;7(3):165-8
pubmed: 16858629
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E751-60
pubmed: 20103737
Ageing Res Rev. 2010 Jul;9(3):289-97
pubmed: 20105461
Cell Metab. 2012 Sep 5;16(3):336-47
pubmed: 22958919
Genes Dev. 2004 Dec 15;18(24):3004-9
pubmed: 15574588
Nat Rev Cancer. 2015 Oct;15(10):608-24
pubmed: 26383140
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11533-8
pubmed: 11572996
Mech Ageing Dev. 2010 Nov-Dec;131(11-12):739-42
pubmed: 20934448
Age (Omaha). 1997 Jan;20(1):45-56
pubmed: 23604290
Nihon Ronen Igakkai Zasshi. 1995 Jul;32(7):485-90
pubmed: 7500551
Aging (Albany NY). 2009 Aug 15;1(9):771-83
pubmed: 20157566
Cell Metab. 2020 Mar 3;31(3):472-492
pubmed: 32130880
Science. 2009 Oct 2;326(5949):140-4
pubmed: 19797661
Free Radic Res. 2006 Dec;40(12):1303-23
pubmed: 17090420
Aging Cell. 2014 Aug;13(4):769-71
pubmed: 24618355
J Am Coll Nutr. 2009 Aug;28 Suppl:500S-516S
pubmed: 20234038
Rejuvenation Res. 2008 Jun;11(3):605-9
pubmed: 18593278
J Gerontol. 1990 Sep;45(5):B148-63
pubmed: 2394908
Cell. 2020 Mar 5;180(5):984-1001.e22
pubmed: 32109414
Mech Ageing Dev. 2017 Jul;165(Pt B):98-106
pubmed: 28286215
Int J Mol Sci. 2019 Apr 24;20(8):
pubmed: 31022953
JAMA. 2006 Apr 5;295(13):1539-48
pubmed: 16595757
Nutrients. 2020 Feb 06;12(2):
pubmed: 32041168
Diabetes. 2012 Jun;61(6):1315-22
pubmed: 22618766
Aging (Albany NY). 2021 Mar 2;13(5):6375-6405
pubmed: 33653967
PLoS One. 2019 Oct 22;14(10):e0222763
pubmed: 31639130
J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1474-84
pubmed: 24444611
Hum Hered. 2001;52(3):136-9
pubmed: 11588396
Int J Epidemiol. 2004 Dec;33(6):1345-52
pubmed: 15218014
Nat Rev Mol Cell Biol. 2014 Mar;15(3):155-62
pubmed: 24556838
PLoS One. 2011 Jan 25;6(1):e16144
pubmed: 21283571
Curr Vasc Pharmacol. 2014;12(5):718-25
pubmed: 24350924
J Gerontol A Biol Sci Med Sci. 2004 Oct;59(10):997-1006
pubmed: 15528772
J Gerontol. 1991 Sep;46(5):B180-7
pubmed: 1716275
Nutrition. 2017 Mar;35:14-20
pubmed: 28241983
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):516-21
pubmed: 19304940
Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165765
pubmed: 32169505
Annu Rev Nutr. 2018 Aug 21;38:329-356
pubmed: 29852087
Science. 1997 Aug 15;277(5328):942-6
pubmed: 9252323
PLoS Biol. 2008 Oct 28;6(10):e254
pubmed: 18959478
Mol Cell Endocrinol. 2017 Nov 5;455:148-157
pubmed: 28412520
Microbiome. 2021 Dec 15;9(1):240
pubmed: 34906228
Cell. 2017 Jun 15;169(7):1249-1262.e13
pubmed: 28622510
Aging Cell. 2017 Oct;16(5):1200-1203
pubmed: 28677323
Cell Metab. 2013 Jan 8;17(1):101-12
pubmed: 23312286
Elife. 2017 Aug 22;6:
pubmed: 28826469
FEBS J. 2016 Aug;283(16):2987-3001
pubmed: 26934201
Mech Ageing Dev. 2017 Jul;165(Pt B):86-97
pubmed: 28040447
Sci Rep. 2018 Oct 3;8(1):14778
pubmed: 30283130
Adv Geriatr Med Res. 2020;2(3):
pubmed: 32743561
Environ Health Perspect. 1998 Feb;106 Suppl 1:313-24
pubmed: 9539025
J Clin Endocrinol Metab. 1997 Jul;82(7):2093-6
pubmed: 9215277
iScience. 2019 Jul 26;17:155-166
pubmed: 31279933
Am J Clin Nutr. 2006 Nov;84(5):1033-42
pubmed: 17093155
Nutrients. 2021 Apr 28;13(5):
pubmed: 33925037
Nat Commun. 2014 Apr 01;5:3557
pubmed: 24691430
Nat Commun. 2013;4:2163
pubmed: 23860099
Psychol Health Med. 2022 Mar;27(3):728-733
pubmed: 35128993
Cell Rep. 2019 Oct 1;29(1):236-248.e3
pubmed: 31577953
Sci Rep. 2018 Aug 29;8(1):13037
pubmed: 30158649
Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141
pubmed: 33353981
Int J Environ Res Public Health. 2021 Jun 19;18(12):
pubmed: 34205297
Cell Rep. 2014 Sep 25;8(6):1767-1780
pubmed: 25199830
Aging Cell. 2015 Dec;14(6):1055-66
pubmed: 26176567
J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1459-1464
pubmed: 29300832
J Clin Endocrinol Metab. 2006 Aug;91(8):3232-5
pubmed: 16720655
Exp Gerontol. 2008 Feb;43(2):74-8
pubmed: 17697759
Science. 2002 Aug 2;297(5582):811
pubmed: 12161648
J Gerontol. 1990 Mar;45(2):B52-8
pubmed: 2313040
Thyroid Res. 2012 Nov 24;5(1):16
pubmed: 23176389
Microbiome. 2014 Dec 05;2(1):50
pubmed: 25520805
Mech Ageing Dev. 2017 Jul;165(Pt B):75-79
pubmed: 27845177
Biochem Biophys Res Commun. 2017 Aug 26;490(3):636-642
pubmed: 28630003
J Biol Chem. 2005 May 27;280(21):20589-95
pubmed: 15788402
Sci Rep. 2017 Sep 20;7(1):11955
pubmed: 28931850
Mech Ageing Dev. 2020 Mar;186:111199
pubmed: 31899226