Role of miR-133/Dio3 Axis in the T3-Dependent Modulation of Cardiac mitoK-ATP Expression.
Dio3
cardiac ischemia/reperfusion
low T3 state
miRNA
mitoK
mitoK-ATP
mitoSur
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jun 2022
11 Jun 2022
Historique:
received:
26
05
2022
revised:
08
06
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
The opening of the ATP-sensitive mitochondrial potassium channel (mitok-ATP) is a common goal of cardioprotective strategies in the setting of acute and chronic myocardial disease. The biologically active thyroid hormone (TH), 3-5-3-triiodothyronine (T3), has been indicated as a potential activator of mitoK-ATP but the underlying mechanisms are still elusive. Here we describe a novel role of T3 in the transcriptional regulation of mitoK and mitoSur, the recently identified molecular constituents of the channel. To mimic human ischemic heart damage, we used a rat model of a low T3 state as the outcome of a myocardial ischemia/reperfusion event, and neonatal rat cardiomyocytes (NRCM) challenged with hypoxia or H
Identifiants
pubmed: 35742991
pii: ijms23126549
doi: 10.3390/ijms23126549
pmc: PMC9223604
pii:
doi:
Substances chimiques
MIRN133 microRNA, rat
0
MicroRNAs
0
Potassium Channels
0
Triiodothyronine
06LU7C9H1V
Adenosine Triphosphate
8L70Q75FXE
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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